Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis
Article Category: Review
Published Online: Mar 22, 2023
Page range: 12 - 19
Received: Oct 21, 2022
Accepted: Jan 31, 2023
DOI: https://doi.org/10.2478/raon-2023-0013
© 2023 Jelena Kostic Peric, Andja Cirkovic, Sanja Srzentic Drazilov, Natalija Samardzic, Vesna Skodric Trifunovic, Dragana Jovanovic, Sonja Pavlovic, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Background
Thymomas belong to rare tumors giving rise to thymic epithelial tissue. There is a classification of several forms of thymoma: A, AB, B1, B2, B3, thymic carcinoma (TC) and thymic neuroendocrine thymoma. In this meta-analysis study, we have focused on thymoma using articles based on the disease’s next-generation sequencing (NGS) genomic profiling.
Materials and methods
We conducted a systematic review and meta-analysis of the prevalence of studies that discovered the genes and variants occurring in the less aggressive forms of the thymic epithelial tumors. Studies published before 12th December 2022 were identified through PubMed, Web of Science (WoS), and SCOPUS databases. Two reviewers have searched for the bases and selected the articles for the final analysis, based on well-defined exclusion and inclusion criteria.
Results
Finally, 12 publications were included in the qualitative as well as quantitative analysis. The three genes,
Conclusions
According to obtained data, we noticed that the