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MRI-identified multidimensional nodal features predict survival and concurrent chemotherapy benefit for stage II nasopharyngeal carcinoma


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Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet 2019; 394: 64-80. doi: 10.1016/s0140-6736(19)30956-0 Chen YP Chan ATC Le QT Blanchard P Sun Y Ma J Nasopharyngeal carcinoma Lancet 2019 394 64 80 10.1016/s0140-6736(19)30956-031178151Open DOISearch in Google Scholar

Sun X, Su S, Chen C, Han F, Zhao C, Xiao W, et al. Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: an analysis of survival and treatment toxicities. Radiother Oncol 2014; 110: 398-403. doi: 10.1016/j.radonc.2013.10.020 Sun X Su S Chen C Han F Zhao C Xiao W et al Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: an analysis of survival and treatment toxicities Radiother Oncol 2014 110 398 403 10.1016/j.radonc.2013.10.02024231245Open DOISearch in Google Scholar

Tian YM, Liu MZ, Zeng L, Bai L, Lin CG, Huang SM, et al. Long-term outcome and pattern of failure for patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy. Head Neck 2019; 41: 1246-52. doi: 10.1002/hed.25545 Tian YM Liu MZ Zeng L Bai L Lin CG Huang SM et al Long-term outcome and pattern of failure for patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy Head Neck 2019 41 1246 52 10.1002/hed.2554530593728Open DOISearch in Google Scholar

National Comprehensive Cancer Network. NCCN Guidelines in Oncology. Head and Neck Cancers. Version 2.2022. [Internet]. [cited 2022 Apr 26]. Available at https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1437 National Comprehensive Cancer Network NCCN Guidelines in Oncology. Head and Neck Cancers. Version 2.2022. [Internet]. [cited 2022 Apr 26] Available at https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1437Search in Google Scholar

Chen QY, Wen YF, Guo L, Liu H, Huang PY, Mo HY, et al. Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial. J Natl Cancer Inst 2011; 103: 1761-70. doi: 10.1093/jnci/djr432 Chen QY Wen YF Guo L Liu H Huang PY Mo HY et al Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial J Natl Cancer Inst 2011 103 1761 70 10.1093/jnci/djr43222056739Open DOISearch in Google Scholar

Su SF, Han F, Zhao C, Chen CY, Xiao WW, Li JX, et al. Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone. Int J Radiat Oncol Biol Phys 2012; 82: 327-33. doi: 10.1016/j.ijrobp.2010.09.011 Su SF Han F Zhao C Chen CY Xiao WW Li JX et al Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone Int J Radiat Oncol Biol Phys 2012 82 327 33 10.1016/j.ijrobp.2010.09.01121035959Open DOISearch in Google Scholar

Huang X, Chen X, Zhao C, Wang J, Wang K, Wang L, et al. Adding concurrent chemotherapy to intensity-modulated radiotherapy does not improve treatment outcomes for stage II nasopharyngeal carcinoma: a phase 2 multicenter clinical trial. Front Oncol 2020; 10: 1314. doi: 10.3389/fonc.2020.01314 Huang X Chen X Zhao C Wang J Wang K Wang L et al Adding concurrent chemotherapy to intensity-modulated radiotherapy does not improve treatment outcomes for stage II nasopharyngeal carcinoma: a phase 2 multicenter clinical trial Front Oncol 2020 10 1314 10.3389/fonc.2020.01314742650632850414Open DOISearch in Google Scholar

Bossi P, Chan AT, Licitra L, Trama A, Orlandi E, Hui EP, et al. Nasopharyngeal carcinoma: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up(dagger). Ann Oncol 2021; 32: 452-65. doi: 10.1016/j. annonc.2020.12.007 Bossi P Chan AT Licitra L Trama A Orlandi E Hui EP et al Nasopharyngeal carcinoma: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up(dagger) Ann Oncol 2021 32 452 65 10.1016/j.annonc.2020.12.00733358989Open DOISearch in Google Scholar

Sun XS, Li XY, Xiao BB, Liu SL, Chen QY, Tang LQ, et al. Establishment and validation of a nomogram for predicting the benefit of concurrent chemotherapy in stage II nasopharyngeal carcinoma: a study based on a phase III randomized clinical trial with 10-year follow-up. Oral Oncol 2020; 100: 104490. doi: 10.1016/j.oraloncology.2019.104490 Sun XS Li XY Xiao BB Liu SL Chen QY Tang LQ et al Establishment and validation of a nomogram for predicting the benefit of concurrent chemotherapy in stage II nasopharyngeal carcinoma: a study based on a phase III randomized clinical trial with 10-year follow-up Oral Oncol 2020 100 104490 10.1016/j.oraloncology.2019.10449031790913Open DOISearch in Google Scholar

He SS, Wang CT, Peng ZW, Ren YF, Lu LX, Chen RW, et al. Development and external validation of a nomogram for predicting the overall survival of patients with stage II nasopharyngeal carcinoma after curative treatment. Cancer Manag Res 2019; 11: 4403-12. doi: 10.2147/CMAR.S202151 He SS Wang CT Peng ZW Ren YF Lu LX Chen RW et al Development and external validation of a nomogram for predicting the overall survival of patients with stage II nasopharyngeal carcinoma after curative treatment Cancer Manag Res 2019 11 4403 12 10.2147/CMAR.S202151651902131191003Open DOISearch in Google Scholar

Chen YP, Ismaila N, Chua MLK, Colevas AD, Haddad R, Huang SH, et al. Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma: CSCO and ASCO guideline. J Clin Oncol 2021; 39: 840-59. doi: 10.1200/jco.20.03237 Chen YP Ismaila N Chua MLK Colevas AD Haddad R Huang SH et al Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma: CSCO and ASCO guideline J Clin Oncol 2021 39 840 59 10.1200/jco.20.03237Open DOISearch in Google Scholar

Du YY, Luo DH, Sun XS, Tang LQ, Mai HQ, Chen QY, et al. Combining pretreatment plasma Epstein-Barr virus DNA level and cervical node necrosis improves prognostic stratification in patients with nasopharyngeal carcinoma: a cohort study. Cancer Med 2019; 8: 6841-52. doi: 10.1002/cam4.2481 Du YY Luo DH Sun XS Tang LQ Mai HQ Chen QY et al Combining pretreatment plasma Epstein-Barr virus DNA level and cervical node necrosis improves prognostic stratification in patients with nasopharyngeal carcinoma: a cohort study Cancer Med 2019 8 6841 52 10.1002/cam4.2481685382231513364Open DOISearch in Google Scholar

Hu Y, Lu T, Huang SH, Lin S, Chen Y, Fang Y, et al. High-grade radiologic extra-nodal extension predicts distant metastasis in stage II nasopharyngeal carcinoma. Head Neck 2019; 41: 3317-27. doi: 10.1002/hed.25842 Hu Y Lu T Huang SH Lin S Chen Y Fang Y et al High-grade radiologic extra-nodal extension predicts distant metastasis in stage II nasopharyngeal carcinoma Head Neck 2019 41 3317 27 10.1002/hed.2584231206864Open DOISearch in Google Scholar

Liu Y, Chen S, Dong A, Ai F, Quan T, Cui C, et al. Nodal grouping in naso-pharyngeal carcinoma: prognostic significance, N classification, and a marker for the identification of candidates for induction chemotherapy. Eur Radiol 2020; 30: 2115-24. doi: 10.1007/s00330-019-06537-6 Liu Y Chen S Dong A Ai F Quan T Cui C et al Nodal grouping in naso-pharyngeal carcinoma: prognostic significance, N classification, and a marker for the identification of candidates for induction chemotherapy Eur Radiol 2020 30 2115 24 10.1007/s00330-019-06537-631811429Open DOISearch in Google Scholar

Lin TY, Lan MY, Tsou HH, Ho CY, Twu CW, Liu YC, et al. Survival impacts of different nodal characteristics and T-classification in N3 nasopharyngeal carcinoma patients. Oral Oncol 2020; 108: 104820. doi: 10.1016/j.oraloncology.2020.104820 Lin TY Lan MY Tsou HH Ho CY Twu CW Liu YC et al Survival impacts of different nodal characteristics and T-classification in N3 nasopharyngeal carcinoma patients Oral Oncol 2020 108 104820 10.1016/j.oraloncology.2020.10482032531741Open DOISearch in Google Scholar

Chen X, Cao X, Jing B, Xia W, Ke L, Xiang Y, et al. Prognostic and treatment guiding significance of MRI-based tumor burden features and nodal necrosis in nasopharyngeal carcinoma. Front Oncol 2020; 10: 537318. doi: 10.3389/fonc.2020.537318 Chen X Cao X Jing B Xia W Ke L Xiang Y et al Prognostic and treatment guiding significance of MRI-based tumor burden features and nodal necrosis in nasopharyngeal carcinoma Front Oncol 2020 10 537318 10.3389/fonc.2020.537318751831333042831Open DOISearch in Google Scholar

Ai QY, King AD, Poon DMC, Mo FKF, Hui EP, Tong M, et al. Extranodal extension is a criterion for poor outcome in patients with metastatic nodes from cancer of the nasopharynx. Oral Oncol 2019; 88: 124-30. doi: 10.1016/j. oraloncology.2018.11.007 Ai QY King AD Poon DMC Mo FKF Hui EP Tong M et al Extranodal extension is a criterion for poor outcome in patients with metastatic nodes from cancer of the nasopharynx Oral Oncol 2019 88 124 30 10.1016/j.oraloncology.2018.11.00730616782Open DOISearch in Google Scholar

Lu T, Hu Y, Xiao Y, Guo Q, Huang SH, O’Sullivan B, et al. Prognostic value of radiologic extranodal extension and its potential role in future N classification for nasopharyngeal carcinoma. Oral Oncol 2019; 99: 104438. doi: 10.1016/j. oraloncology.2019.09.030 Lu T Hu Y Xiao Y Guo Q Huang SH O’Sullivan B et al Prognostic value of radiologic extranodal extension and its potential role in future N classification for nasopharyngeal carcinoma Oral Oncol 2019 99 104438 10.1016/j.oraloncology.2019.09.03031654937Open DOISearch in Google Scholar

Lan M, Huang Y, Chen CY, Han F, Wu SX, Tian L, et al. Prognostic value of cervical nodal necrosis in nasopharyngeal carcinoma: analysis of 1800 patients with positive cervical nodal metastasis at MR imaging. Radiology 2015; 276: 619. doi: 10.1148/radiol.15141251 Lan M Huang Y Chen CY Han F Wu SX Tian L et al Prognostic value of cervical nodal necrosis in nasopharyngeal carcinoma: analysis of 1800 patients with positive cervical nodal metastasis at MR imaging Radiology 2015 276 619 10.1148/radiol.1514125125759968Open DOISearch in Google Scholar

Li JY, Huang CL, Luo WJ, Zhang Y, Tang LL, Peng H, et al. An integrated model of the gross tumor volume of cervical lymph nodes and pretreatment plasma Epstein-Barr virus DNA predicts survival of nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: a big-data intelligence platform-based analysis. Ther Adv Med Oncol 2019; 11: 1758835919877729. doi: 10.1177/1758835919877729 Li JY Huang CL Luo WJ Zhang Y Tang LL Peng H et al An integrated model of the gross tumor volume of cervical lymph nodes and pretreatment plasma Epstein-Barr virus DNA predicts survival of nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: a big-data intelligence platform-based analysis Ther Adv Med Oncol 2019 11 1758835919877729 10.1177/1758835919877729676394531598143Open DOISearch in Google Scholar

Huang CL, Chen Y, Guo R, Mao YP, Xu C, Tian L, et al. Prognostic value of MRI-determined cervical lymph node size in nasopharyngeal carcinoma. Cancer Med 2020; 9: 7100-6. doi: 10.1002/cam4.3392 Huang CL Chen Y Guo R Mao YP Xu C Tian L et al Prognostic value of MRI-determined cervical lymph node size in nasopharyngeal carcinoma Cancer Med 2020 9 7100 6 10.1002/cam4.3392754116232794334Open DOISearch in Google Scholar

Ma H, Liang S, Cui C, Zhang Y, Xie F, Zhou J, et al. Prognostic significance of quantitative metastatic lymph node burden on magnetic resonance imaging in nasopharyngeal carcinoma: a retrospective study of 1224 patients from two centers. Radiother Oncol 2020; 51: 40-6. doi: 10.1016/j. radonc.2020.07.023 Ma H Liang S Cui C Zhang Y Xie F Zhou J et al Prognostic significance of quantitative metastatic lymph node burden on magnetic resonance imaging in nasopharyngeal carcinoma: a retrospective study of 1224 patients from two centers Radiother Oncol 2020 51 40 6 10.1016/j.radonc.2020.07.02332679310Open DOISearch in Google Scholar

Zhou X, Ou X, Yang Y, Xu T, Shen C, Ding J, et al. Quantitative metastatic lymph node regions on magnetic resonance imaging are superior to AJCC N classification for the prognosis of nasopharyngeal carcinoma. J Oncol 2018; 2018: 9172585. doi: 10.1155/2018/9172585 Zhou X Ou X Yang Y Xu T Shen C Ding J et al Quantitative metastatic lymph node regions on magnetic resonance imaging are superior to AJCC N classification for the prognosis of nasopharyngeal carcinoma J Oncol 2018 2018 9172585 10.1155/2018/9172585630454630631357Open DOISearch in Google Scholar

van den Brekel MW, Stel HV, Castelijns JA, Nauta JJ, van der Waal I, Valk J, et al. Cervical lymph node metastasis: assessment of radiologic criteria. Radiology 1990; 177: 379-84. doi: 10.1148/radiology.177.2.2217772 van den Brekel MW Stel HV Castelijns JA Nauta JJ van der Waal I Valk J et al Cervical lymph node metastasis: assessment of radiologic criteria Radiology 1990 177 379 84 10.1148/radiology.177.2.22177722217772Open DOISearch in Google Scholar

Meira-Machado L, Cadarso-Suarez C, Gude F, Araujo A. smoothHR: an R package for pointwise nonparametric estimation of hazard ratio curves of continuous predictors. Comput Math Methods Med 2013; 2013: 745742. doi: 10.1155/2013/745742 Meira-Machado L Cadarso-Suarez C Gude F Araujo A smoothHR: an R package for pointwise nonparametric estimation of hazard ratio curves of continuous predictors Comput Math Methods Med 2013 2013 745742 10.1155/2013/745742387671824454541Open DOISearch in Google Scholar

Liu DH, Zhou XY, Pan YG, Chen S, Ye ZH, Chen GD. Survival of stage II nasopharyngeal carcinoma patients with or without concurrent chemotherapy: a propensity score matching study. Cancer Med 2020; 9: 1287-97. doi: 10.1002/cam4.2785 Liu DH Zhou XY Pan YG Chen S Ye ZH Chen GD Survival of stage II nasopharyngeal carcinoma patients with or without concurrent chemotherapy: a propensity score matching study Cancer Med 2020 9 1287 97 10.1002/cam4.2785701307431859464Open DOISearch in Google Scholar

Luo S, Zhao L, Wang J, Xu M, Li J, Zhou B, et al. Clinical outcomes for early-stage nasopharyngeal carcinoma with predominantly WHO II histology treated by intensity-modulated radiation therapy with or without chemotherapy in nonendemic region of China. Head Neck 2014; 36: 841-7. doi: 10.1002/hed.23386 Luo S Zhao L Wang J Xu M Li J Zhou B et al Clinical outcomes for early-stage nasopharyngeal carcinoma with predominantly WHO II histology treated by intensity-modulated radiation therapy with or without chemotherapy in nonendemic region of China Head Neck 2014 36 841 7 10.1002/hed.2338623720240Open DOISearch in Google Scholar

Kang MK, Oh D, Cho KH, Moon SH, Wu HG, Heo D, et al. Role of chemotherapy in stage II nasopharyngeal carcinoma treated with curative radiotherapy. Cancer Res Treat 2015; 47: 871-8. doi: 10.4143/crt.2014.141 Kang MK Oh D Cho KH Moon SH Wu HG Heo D et al Role of chemotherapy in stage II nasopharyngeal carcinoma treated with curative radiotherapy Cancer Res Treat 2015 47 871 8 10.4143/crt.2014.141461420825687858Open DOISearch in Google Scholar

Lee VH, Kwong DL, Leung TW, Choi CW, O’Sullivan B, Lam KO, et al. The addition of pretreatment plasma Epstein-Barr virus DNA into the eighth edition of nasopharyngeal cancer TNM stage classification. Int J Cancer 2019; 144: 1713-22. doi: 10.1002/ijc.31856 Lee VH Kwong DL Leung TW Choi CW O’Sullivan B Lam KO et al The addition of pretreatment plasma Epstein-Barr virus DNA into the eighth edition of nasopharyngeal cancer TNM stage classification Int J Cancer 2019 144 1713 22 10.1002/ijc.3185630192385Open DOISearch in Google Scholar

Guo R, Tang LL, Mao YP, Du XJ, Chen L, Zhang ZC, et al. Proposed modifications and incorporation of plasma Epstein-Barr virus DNA improve the TNM staging system for Epstein-Barr virus-related nasopharyngeal carcinoma. Cancer 2019; 125: 79-89. doi: 10.1002/cncr.31741 Guo R Tang LL Mao YP Du XJ Chen L Zhang ZC et al Proposed modifications and incorporation of plasma Epstein-Barr virus DNA improve the TNM staging system for Epstein-Barr virus-related nasopharyngeal carcinoma Cancer 2019 125 79 89 10.1002/cncr.3174130351466Open DOISearch in Google Scholar

Leung SF, Zee B, Ma BB, Hui EP, Mo F, Lai M, et al. Plasma Epstein-Barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma. J Clin Oncol 2006; 24: 5414-18. doi: 10.1200/JCO.2006.07.7982 Leung SF Zee B Ma BB Hui EP Mo F Lai M et al Plasma Epstein-Barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma J Clin Oncol 2006 24 5414 18 10.1200/JCO.2006.07.798217135642Open DOISearch in Google Scholar

Sun XS, Chen WH, Liu SL, Liang YJ, Chen QY, Guo SS, et al. Individualized concurrent chemotherapy by pretreatment plasma Epstein-Barr viral DNA in II-III stage nasopharyngeal carcinoma: a propensity score matching analysis using a large cohort. Cancer Med 2019; 8: 4214-25. doi: 10.1002/cam4.2343 Sun XS Chen WH Liu SL Liang YJ Chen QY Guo SS et al Individualized concurrent chemotherapy by pretreatment plasma Epstein-Barr viral DNA in II-III stage nasopharyngeal carcinoma: a propensity score matching analysis using a large cohort Cancer Med 2019 8 4214 25 10.1002/cam4.2343667574531210417Open DOISearch in Google Scholar

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