Nanosecond electric pulses are equally effective in electrochemotherapy with cisplatin as microsecond pulses

1Miklavčič D, Mali B, Kos B, Heller R, Serša G. Electrochemotherapy: from the drawing board into medical practice. BioMed Eng Online 2014; 13: 1-20. doi: 10.1186/1475-925X-13-29 Miklavčič D Mali B Kos B Heller R Serša G Electrochemotherapy: from the drawing board into medical practice BioMed Eng Online 2014 13 1 20 10.1186/1475-925X-13-29399570524621079Open DOISearch in Google Scholar

2Campana LG, Miklavčič D, Bertino G, Marconato R, Valpione S, Imarisio I, M, et al. Electrochemotherapy of superficial tumors – Current status: basic principles, operating procedures, shared indications, and emerging applications. Semin Oncol 2019; 46: 173-91. doi: 10.1053/j.seminoncol.2019.04.002 Campana LG Miklavčič D Bertino G Marconato R Valpione S Imarisio I M, et al Electrochemotherapy of superficial tumors – Current status: basic principles, operating procedures, shared indications, and emerging applications Semin Oncol 2019 46 173 91 10.1053/j.seminoncol.2019.04.00231122761Open DOISearch in Google Scholar

3Gehl J, Sersa G, Matthiessen LW, Muir T, Soden D, Occhini A, Quaglino P, et al. Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases. Acta Oncol 2018; 57: 874-82. doi: 10.1080/0284186X.2018.1454602 Gehl J Sersa G Matthiessen LW Muir T Soden D Occhini A Quaglino P et al Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases Acta Oncol 2018 57 874 82 10.1080/0284186X.2018.145460229577784Open DOISearch in Google Scholar

4Kendler M, Micheluzzi M, Wetzig T, Simon JC. Electrochemotherapy under tumescent local anesthesia for the treatment of cutaneous metastases. Dermatologic Surg 2013; 39: 1023-32. doi: 10.1111/dsu.12190 Kendler M Micheluzzi M Wetzig T Simon JC Electrochemotherapy under tumescent local anesthesia for the treatment of cutaneous metastases Dermatologic Surg 2013 39 1023 32 10.1111/dsu.1219023464631Open DOISearch in Google Scholar

5Schoenbach KH, Beebe SJ, Buescher ES. Intracellular effect of ultrashort electrical pulses. Bioelectromagnetics 2001; 22: 440-8. doi: 10.1002/bem.71 Schoenbach KH Beebe SJ Buescher ES Intracellular effect of ultrashort electrical pulses Bioelectromagnetics 2001 22 440 8 10.1002/bem.7111536285Open DOISearch in Google Scholar

6Pliquett U, Nuccitelli R. Measurement and simulation of Joule heating during treatment of B-16 melanoma tumors in mice with nanosecond pulsed electric fields. Bioelectrochemistry 2014; 100: 62-8. doi: 10.1016/j.bioelechem.2014.03.001 Pliquett U Nuccitelli R Measurement and simulation of Joule heating during treatment of B-16 melanoma tumors in mice with nanosecond pulsed electric fields Bioelectrochemistry 2014 100 62 8 10.1016/j.bioelechem.2014.03.00124680133Open DOISearch in Google Scholar

7Cornelis FH, Cindrič H, Kos B, Fujimori M, Petre EN, Miklavčič D, et al. Peritumoral metallic implants reduce the efficacy of irreversible electroporation for the ablation of colorectal liver metastases. Cardiovas Intervent Radiol 2020; 43: 84-93. doi: 10.1007/s00270-019-02300-y Cornelis FH Cindrič H Kos B Fujimori M Petre EN Miklavčič D et al Peritumoral metallic implants reduce the efficacy of irreversible electroporation for the ablation of colorectal liver metastases Cardiovas Intervent Radiol 2020 43 84 93 10.1007/s00270-019-02300-y694224031385006Open DOISearch in Google Scholar

8Vižintin A, Marković S, Ščančar J, Miklavčič D. Electroporation with nanosecond pulses and bleomycin or cisplatin results in efficient cell kill and low metal release from electrodes. Bioelectrochemistry 2021; 140: 107898. doi: 10.1016/j.bioelechem.2021.107798 Vižintin A Marković S Ščančar J Miklavčič D Electroporation with nanosecond pulses and bleomycin or cisplatin results in efficient cell kill and low metal release from electrodes Bioelectrochemistry 2021 140 107898 10.1016/j.bioelechem.2021.10779833743336Open DOISearch in Google Scholar

9Saulis G, Rodaite R, Rodaitė-Riševičienė R, Dainauskaitė VS, Saulė R. Electrochemical processes during high-voltage electric pulses and their importance in food processing technology. In: Rai VR, editor. Advances in food biotechnology. First Edition. Wiley Online Books, John Wiley & Sons Ltd; 2016. p. 575-92. Saulis G Rodaite R Rodaitė-Riševičienė R Dainauskaitė VS Saulė R Electrochemical processes during high-voltage electric pulses and their importance in food processing technology In Rai VR editor Advances in food biotechnology. First Edition Wiley Online Books, John Wiley & Sons Ltd 2016 p 575–9210.1002/9781118864463.ch35Search in Google Scholar

10Kotnik T, Miklavčič D, Mir LM. Cell membrane electropermeabilization by symmetrical bipolar rectangular pulses: Part II. Reduced electrolytic contamination. Bioelectrochemistry 2001; 54: 91-5. doi: 10.1016/S1567-5394(01)00115-3 Kotnik T Miklavčič D Mir LM Cell membrane electropermeabilization by symmetrical bipolar rectangular pulses: Part II Reduced electrolytic contamination. Bioelectrochemistry 2001 54 91 5 10.1016/S1567-5394(01)00115-311506979Open DOISearch in Google Scholar

11Loomis-Husselbee JW, Cullen PJ, Irvine RF, Dawson AP. Electroporation can cause artefacts due to solubilization of cations from the electrode plates. Aluminum ions enhance conversion of inositol 1,3,4,5-tetrakisphosphate into inositol 1,4,5-trisphosphate in electroporated L1210 cells. Biochem J 1991; 277(Pt 3): 883-5. doi: 10.1042/bj2770883 Loomis-Husselbee JW Cullen PJ Irvine RF Dawson AP Electroporation can cause artefacts due to solubilization of cations from the electrode plates Aluminum ions enhance conversion of inositol 1,3,4,5-tetrakisphosphate into inositol 1,4,5-trisphosphate in electroporated L1210 cells. Biochem J 1991 277Pt 3 883 5 10.1042/bj277088311513271872818Open DOISearch in Google Scholar

12Long G, Shires PK, Plescia D, Beebe SJ, Kolb JF, Schoenbach KH. Targeted tissue ablation with nanosecond pulses. IEEE Trans Biomed Eng 2011; 58: 2161-7. doi: 10.1109/TBME.2011.2113183 Long G Shires PK Plescia D Beebe SJ Kolb JF Schoenbach KH Targeted tissue ablation with nanosecond pulses IEEE Trans Biomed Eng 2011 58 2161 7 10.1109/TBME.2011.211318321317072Open DOISearch in Google Scholar

13Rogers WR, Merritt JH, Comeaux JA, Kuhnel CT, Moreland DF, Teltschik DG, et al. Strength-duration curve an electrically excitable tissue extended down to near 1 nanosecond. IEEE Trans on Plasma Sci 2004; 32: 1587-99. doi: 10.1109/TPS.2004.831758 Rogers WR Merritt JH Comeaux JA Kuhnel CT Moreland DF Teltschik DG et al Strength-duration curve an electrically excitable tissue extended down to near 1 nanosecond IEEE Trans on Plasma Sci 2004 32 1587 99 10.1109/TPS.2004.831758Open DOISearch in Google Scholar

14Pakhomov AG, Pakhomova ON. The interplay of excitation and electroporation in nanosecond pulse stimulation. Bioelectrochemistry 2020; 136: 107598. doi: 10.1016/j.bioelechem.2020.107598 Pakhomov AG Pakhomova ON The interplay of excitation and electroporation in nanosecond pulse stimulation Bioelectrochemistry 2020 136 107598 10.1016/j.bioelechem.2020.107598751124732711366Open DOISearch in Google Scholar

15Gudvangen EK, Kondratiev O, Redondo L, Xiao S, Pakhomov AG. Peculiarities of neurostimulation by intense nanosecond pulsed electric fields: how to avoid firing in peripheral nerve fibers. Int J Mol Sci 2021; 22: 1763. doi: 10.3390/ijms22137051 Gudvangen EK Kondratiev O Redondo L Xiao S Pakhomov AG Peculiarities of neurostimulation by intense nanosecond pulsed electric fields: how to avoid firing in peripheral nerve fibers Int J Mol Sci 2021 22 1763 10.3390/ijms22137051826903134208945Open DOISearch in Google Scholar

16Gudvangen EK, Novickij V, Battista F, Pakhomov AG. Electroporation and cell killing by milli-to nanosecond pulses and avoiding neuromuscular stimulation in cancer ablation. Sci Rep 2022; 12: 1-15. doi: 10.1038/s41598-022-04868-x Gudvangen EK Novickij V Battista F Pakhomov AG Electroporation and cell killing by milli-to nanosecond pulses and avoiding neuromuscular stimulation in cancer ablation Sci Rep 2022 12 1 15 10.1038/s41598-022-04868-x881101835110567Open DOISearch in Google Scholar

17Silve A, Leray I, Mir LM. Demonstration of cell membrane permeabilization to medium-sized molecules caused by a single 10 ns electric pulse. Bioelectrochemistry 2012; 87: 260-4. doi: https://doi.org/10.1016/j.bioelechem.2011.10.002 Silve A Leray I Mir LM Demonstration of cell membrane permeabilization to medium-sized molecules caused by a single 10 ns electric pulse Bioelectrochemistry 2012 87 260 4 https://doi.org/10.1016/j.bioelechem.2011.10.00222074790Open DOISearch in Google Scholar

18Tunikowska J, Antończyk A, Rembiałkowska N, Jóźwiak Ł, Novickij V, Kulbacka J. The first application of nanoelectrochemotherapy in feline oral malignant melanoma treatment – case study. Animals 2020; 10: 556. doi: 10.3390/ani10040556 Tunikowska J Antończyk A Rembiałkowska N Jóźwiak Ł Novickij V Kulbacka J The first application of nanoelectrochemotherapy in feline oral malignant melanoma treatment – case study Animals 2020 10 556 10.3390/ani10040556722240532225098Open DOISearch in Google Scholar

19Novickij V, Malyško V, Želvys A, Balevičiūte A, Zinkevičiene A, Novickij J, et al. Electrochemotherapy using doxorubicin and nanosecond electric field pulses: a pilot in vivo study. Molecules 2020; 25: 4601. doi: 10.3390/molecules25204601 Novickij V Malyško V Želvys A Balevičiūte A Zinkevičiene A Novickij J et al Electrochemotherapy using doxorubicin and nanosecond electric field pulses: a pilot in vivo study Molecules 2020 25 4601 10.3390/molecules25204601758717933050300Open DOISearch in Google Scholar

20Kiełbik A, Szlasa W, Novickij V, Szewczyk A, Maciejewska M, Saczko J, et al. Effects of high-frequency nanosecond pulses on prostate cancer cells. Sci Rep 2021; 11: 1-10. doi: 10.1038/s41598-021-95180-7 Kiełbik A Szlasa W Novickij V Szewczyk A Maciejewska M Saczko J et al Effects of high-frequency nanosecond pulses on prostate cancer cells Sci Rep 2021 11 1 10 10.1038/s41598-021-95180-7833906634349171Open DOISearch in Google Scholar

21Kulbacka J, Rembiałkowska N, Szewczyk A, Moreira H, Szyjka A, Girkontaitė I, et al. The impact of extracellular Ca2+ and nanosecond electric pulses on sensitive and drug-resistant human breast and colon cancer cells. Cancers 2021; 13: 3216. doi: 10.3390/cancers13133216 Kulbacka J Rembiałkowska N Szewczyk A Moreira H Szyjka A Girkontaitė I et al The impact of extracellular Ca2+ and nanosecond electric pulses on sensitive and drug-resistant human breast and colon cancer cells Cancers 2021 13 3216 10.3390/cancers13133216826841834203184Open DOISearch in Google Scholar

22R Core Team R. A language and environment for statistical computing. [internet]. 2018. Available at: https://www.r-project.org/ R Core Team R A language and environment for statistical computing. [internet] 2018 Available at https://www.r-project.org/Search in Google Scholar

23Berners-Price SJ, Appleton TG. The chemistry of cisplatin in aqueous solution. In: Kelland LR, Farrell NP, editors. Platinum-based drugs in cancer therapy. Cancer drug discovery and development. Totowa, NJ: Humana Press; 2000. p. 3-35. doi: 10.1007/978-1-59259-012-4_1 Berners-Price SJ Appleton TG The chemistry of cisplatin in aqueous solution In Kelland LR Farrell NP editors Platinum-based drugs in cancer therapy. Cancer drug discovery and development Totowa, NJ Humana Press 2000 p 3–35 10.1007/978-1-59259-012-4_1Open DOISearch in Google Scholar

24Chen Y, Guo Z, Sadler PJ. 195Pt- and 15N-NMR spectroscopic studies of cisplatin reactions with biomolecules. In: Lippert B, editor. Cisplatin. Chemistry and biochemistry of a leading anticancer drug. Wiley Online Library. p. 293-318. doi: 10.1002/9783906390420.ch11 Chen Y Guo Z Sadler PJ 195Pt- and 15N-NMR spectroscopic studies of cisplatin reactions with biomolecules In Lippert B editor Cisplatin. Chemistry and biochemistry of a leading anticancer drug Wiley Online Library p 293–318 10.1002/9783906390420.ch11Open DOISearch in Google Scholar

25Cui M, Mester Z. Electrospray ionization mass spectrometry coupled to liquid chromatography for detection of cisplatin and its hydrated complexes. Rapid Commun Mass Spectrom 2003; 17: 1517-27. doi: 10.1002/rcm.1030 Cui M Mester Z Electrospray ionization mass spectrometry coupled to liquid chromatography for detection of cisplatin and its hydrated complexes Rapid Commun Mass Spectrom 2003 17 1517 27 10.1002/rcm.103012845575Open DOISearch in Google Scholar

26Feifan X, Pieter C, Jan VB. Electrospray ionization mass spectrometry for the hydrolysis complexes of cisplatin: implications for the hydrolysis process of platinum complexes. J Mass Spectrom 2017; 52: 434-41. doi: https://doi.org/10.1002/jms.3940 Feifan X Pieter C Jan VB Electrospray ionization mass spectrometry for the hydrolysis complexes of cisplatin: implications for the hydrolysis process of platinum complexes J Mass Spectrom 2017 52 434 41 https://doi.org/10.1002/jms.394028444903Open DOISearch in Google Scholar

27Du Y, Zhang N, Cui M, Liu Z, Liu S. Investigation on the hydrolysis of the anticancer drug cisplatin by Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom 2012; 26: 2832-6. doi: https://doi.org/10.1002/rcm.6408 Du Y Zhang N Cui M Liu Z Liu S Investigation on the hydrolysis of the anticancer drug cisplatin by Fourier transform ion cyclotron resonance mass spectrometry Rapid Commun Mass Spectrom 2012 26 2832 6 https://doi.org/10.1002/rcm.640823124676Open DOISearch in Google Scholar

28Cui M, Ding L, Mester Z. Separation of cisplatin and its hydrolysis products using electrospray ionization high-field asymmetric waveform ion mobility spectrometry coupled with ion trap mass spectrometry. Anal Chem 2003; 75: 5847-53. doi: 10.1021/ac0344182 Cui M Ding L Mester Z Separation of cisplatin and its hydrolysis products using electrospray ionization high-field asymmetric waveform ion mobility spectrometry coupled with ion trap mass spectrometry Anal Chem 2003 75 5847 53 10.1021/ac034418214588025Open DOISearch in Google Scholar

29Arena CB, Sano MB, Rossmeisl Jr JH, Caldwell JL, Garcia PA, Rylander MN, et al. High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction. BioMed Eng Online e 2011; 10: 102. doi: 10.1186/1475-925X-10-102 Arena CB Sano MB Rossmeisl Jr JH Caldwell JL Garcia PA Rylander MN et al High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction BioMed Eng Online e 2011 10 102 10.1186/1475-925X-10-102325829222104372Open DOISearch in Google Scholar

30Scuderi M, Reberšek M, Miklavčič D, Dermol-Černe J. The use of high-frequency short bipolar pulses in cisplatin electrochemotherapy in vitro. Radiol Oncol 2019; 53: 194-205. doi: 10.2478/raon-2019-0025 Scuderi M Reberšek M Miklavčič D Dermol-Černe J The use of high-frequency short bipolar pulses in cisplatin electrochemotherapy in vitro Radiol Oncol 2019 53 194 205 10.2478/raon-2019-0025657250131194692Open DOISearch in Google Scholar

31Pirc E, Miklavčič D, Uršič K, Serša G, Reberšek M. High-frequency and high-voltage asymmetric bipolar pulse generator for electroporation based technologies and therapies. Electronics 2021; 10: doi: 10.3390/electronics10101203 Pirc E Miklavčič D Uršič K Serša G Reberšek M High-frequency and high-voltage asymmetric bipolar pulse generator for electroporation based technologies and therapies Electronics 2021 10 10.3390/electronics10101203Open DOISearch in Google Scholar

32Makovec T. Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy. Radiol Oncol 2019; 53: 148-58. doi: 10.2478/raon-2019-0018 Makovec T Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy Radiol Oncol 2019 53 148 58 10.2478/raon-2019-0018657249530956230Open DOISearch in Google Scholar

33Hucke A, Ciarimboli G. The role of transporters in the toxicity of chemotherapeutic drugs: focus on transporters for organic cations. J Clin Pharmacol 2016; 56(Suppl 7): S157-72. doi: 10.1002/jcph.706 Hucke A Ciarimboli G The role of transporters in the toxicity of chemotherapeutic drugs: focus on transporters for organic cations J Clin Pharmacol 2016 56Suppl 7 S157 72 10.1002/jcph.70627385173Open DOISearch in Google Scholar

34Kotnik T, Rems L, Tarek M, Miklavčič D. Membrane electroporation and electropermeabilization: mechanisms and models. Annu Rev Biophys 2019; 48: 63-91. doi: 10.1146/annurev-biophys-052118-115451 Kotnik T Rems L Tarek M Miklavčič D Membrane electroporation and electropermeabilization: mechanisms and models Annu Rev Biophys 2019 48 63 91 10.1146/annurev-biophys-052118-11545130786231Open DOISearch in Google Scholar

35Ursic K, Kos S, Kamensek U, Cemazar M, Scancar J, Bucek S, Kranjc S, Staresinic B, Sersa G. Comparable effectiveness and immunomodulatory actions of oxaliplatin and cisplatin in electrochemotherapy of murine melanoma. Bioelectrochemistry 2018; 119: 161-71. doi: 10.1016/j.bioelechem.2017.09.009 Ursic K Kos S Kamensek U Cemazar M Scancar J Bucek S Kranjc S Staresinic B Sersa G Comparable effectiveness and immunomodulatory actions of oxaliplatin and cisplatin in electrochemotherapy of murine melanoma Bioelectrochemistry 2018 119 161 71 10.1016/j.bioelechem.2017.09.00929024870Open DOISearch in Google Scholar

36Zakelj MN, Prevc A, Kranjc S, Cemazar M, Todorovic V, Savarin M, et al. Electrochemotherapy of radioresistant head and neck squamous cell carcinoma cells and tumor xenografts. Oncol Rep 2019; 41: 1658-68. doi: 10.3892/or.2019.6960 Zakelj MN Prevc A Kranjc S Cemazar M Todorovic V Savarin M et al Electrochemotherapy of radioresistant head and neck squamous cell carcinoma cells and tumor xenografts Oncol Rep 2019 41 1658 68 10.3892/or.2019.6960636570530628709Open DOISearch in Google Scholar

37Zhang L, Ye Y, Zhang X, Li X, Chen Q, Sun JCW. Cisplatin under oriented external electric fields: a deeper insight into electrochemotherapy at the molecular level. Int J Quantum Chem 2020; 121: e26578. doi: 10.1002/qua.26578 Zhang L Ye Y Zhang X Li X Chen Q Sun JCW Cisplatin under oriented external electric fields: a deeper insight into electrochemotherapy at the molecular level Int J Quantum Chem 2020 121 e26578 10.1002/qua.26578Open DOISearch in Google Scholar

38Cemază r M, Miklavcĭc ̆ D, Šc̆ăncă r J, Dolză n V, Golouh R, Sersă G. Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin. Br J Cancer 1999; 79: 1386-91. doi: 10.1038/sj.bjc.6690222 Cemază r M Miklavcĭc ̆ D Šc̆ăncă r J Dolză n V Golouh R Sersă G Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin Br J Cancer 1999 79 1386 91 10.1038/sj.bjc.6690222237426410188880Open DOISearch in Google Scholar

39Florea AM, Büsselberg D. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers 2011; 3: 1351-71. doi: 10.3390/cancers3011351 Florea AM Büsselberg D Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects Cancers 2011 3 1351 71 10.3390/cancers3011351375641724212665Open DOISearch in Google Scholar

40Pakhomova ON, Khorokhorina VA, Bowman AM, Rodaite-Riševičiene R, Saulis G, Xiao S, et al. Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free media. Arch Biochem Biophys 2012; 527: 55-64. doi: 10.1016/j.abb.2012.08.004 Pakhomova ON Khorokhorina VA Bowman AM Rodaite-Riševičiene R Saulis G Xiao S et al Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free media Arch Biochem Biophys 2012 527 55 64 10.1016/j.abb.2012.08.004345914822910297Open DOISearch in Google Scholar

41Szlasa W, Kiełbik A, Szewczyk A, Rembiałkowska N, Novickij V, Tarek M, et al. Oxidative effects during irreversible electroporation of melanoma cells – in vitro study. Molecules 2021; 26: doi: 10.3390/molecules26010154 Szlasa W Kiełbik A Szewczyk A Rembiałkowska N Novickij V Tarek M et al Oxidative effects during irreversible electroporation of melanoma cells – in vitro study Molecules 2021 26 10.3390/molecules26010154779637633396317Open DOISearch in Google Scholar

42Batista Napotnik T, Wu Y-H, Gundersen MA, Miklavčič D, Vernier PT. Nanosecond electric pulses cause mitochondrial membrane permeabilization in Jurkat cells. Bioelectromagnetics 2012; 33: 257-64. doi: 10.1002/bem.20707 Batista Napotnik T Wu Y-H Gundersen MA Miklavčič D Vernier PT Nanosecond electric pulses cause mitochondrial membrane permeabilization in Jurkat cells Bioelectromagnetics 2012 33 257 64 10.1002/bem.2070721953203Open DOISearch in Google Scholar

43Nuccitelli R, McDaniel A, Connolly R, Zelickson B, Hartman H. Nano-pulse stimulation induces changes in the intracellular organelles in rat liver tumors treated in situ. Lasers Surg Med 2020; 52: 882-9. doi: 10.1002/lsm.23239 Nuccitelli R McDaniel A Connolly R Zelickson B Hartman H Nano-pulse stimulation induces changes in the intracellular organelles in rat liver tumors treated in situ Lasers Surg Med 2020 52 882 9 10.1002/lsm.23239758695932220023Open DOISearch in Google Scholar

44Semenov I, Xiao S, Pakhomov AG. Primary pathways of intracellular Ca2 + mobilization by nanosecond pulsed electric field. Biochim Biophys Acta - Biomembr 2013; 1828: 981-9. doi: 10.1016/j.bbamem.2012.11.032 Semenov I Xiao S Pakhomov AG Primary pathways of intracellular Ca2 + mobilization by nanosecond pulsed electric field Biochim Biophys Acta - Biomembr 2013 1828 981 9 10.1016/j.bbamem.2012.11.032356032623220180Open DOISearch in Google Scholar

45Frandsen SK, Gissel H, Hojman P, Tramm T, Eriksen J, Gehl J. Direct therapeutic applications of calcium electroporation to effectively induce tumor necrosis. Cancer Res 2012; 72: 1336-41. doi: 10.1158/0008-5472.CAN-11-3782 Frandsen SK Gissel H Hojman P Tramm T Eriksen J Gehl J Direct therapeutic applications of calcium electroporation to effectively induce tumor necrosis Cancer Res 2012 72 1336 41 10.1158/0008-5472.CAN-11-378222282658Open DOISearch in Google Scholar

46Marullo R, Werner E, Degtyareva N, Moore B, Altavilla G, Ramalingam SS, et al. Cisplatin induces a mitochondrial-ros response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions. PLoS ONE 2013; 8: 1-15. doi: 10.1371/journal.pone.0081162 Marullo R Werner E Degtyareva N Moore B Altavilla G Ramalingam SS et al Cisplatin induces a mitochondrial-ros response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions PLoS ONE 2013 8 1 15 10.1371/journal.pone.0081162383421424260552Open DOISearch in Google Scholar

47Kleih M, Böpple K, Dong M, Gaißler A, Heine S, Olayioye MA, et al. Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Cell Death Dis 2019; 10: 31-59. doi: 10.1038/s41419-019-2081-4 Kleih M Böpple K Dong M Gaißler A Heine S Olayioye MA et al Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells Cell Death Dis 2019 10 31 59 10.1038/s41419-019-2081-4683805331699970Open DOISearch in Google Scholar

48Kawai Y, Nakao T, Kunimura N, Kohda Y, Gemba M. Relationship of intracellular calcium and oxygen radicals to cisplatin-related renal cell injury. J Pharmacol Sci 2006; 100: 65-72. doi: 10.1254/jphs.FP0050661 Kawai Y Nakao T Kunimura N Kohda Y Gemba M Relationship of intracellular calcium and oxygen radicals to cisplatin-related renal cell injury J Pharmacol Sci 2006 100 65 72 10.1254/jphs.FP005066116410676Open DOISearch in Google Scholar

49Al-Taweel N, Varghese E, Florea A-M, Büsselberg D. Cisplatin (CDDP) triggers cell death of MCF-7 cells following disruption of intracellular calcium ([Ca2+] i) homeostasis. J Toxicol Sci 2014; 39: 765-74. doi: 10.2131/jts.39.765 Al-Taweel N Varghese E Florea A-M Büsselberg D Cisplatin (CDDP) triggers cell death of MCF-7 cells following disruption of intracellular calcium ([Ca2+] i) homeostasis J Toxicol Sci 2014 39 765 74 10.2131/jts.39.76525242407Open DOISearch in Google Scholar

50Gualdani R, de Clippele M, Ratbi I, Gailly P, Tajeddine N. Store-operated calcium entry contributes to cisplatin-induced cell death in non-small cell lung carcinoma. Cancers 2019; 11: 2023. doi: 10.3390/cancers11030430 Gualdani R de Clippele M Ratbi I Gailly P Tajeddine N Store-operated calcium entry contributes to cisplatin-induced cell death in non-small cell lung carcinoma Cancers 2019 11 2023 10.3390/cancers11030430646867230917547Open DOISearch in Google Scholar

51Michel O, Kulbacka J, Saczko J, Mączyńska J, Błasiak P, Rossowska J, et al. Electroporation with cisplatin against metastatic pancreatic cancer: in vitro study on human primary cell culture. Biomed Res Int 2018; 2018: 7364539. doi: 10.1155/2018/7364539 Michel O Kulbacka J Saczko J Mączyńska J Błasiak P Rossowska J et al Electroporation with cisplatin against metastatic pancreatic cancer: in vitro study on human primary cell culture Biomed Res Int 2018 2018 7364539 10.1155/2018/7364539588443829750170Open DOISearch in Google Scholar

52Speelmans G, Sips WHHM, Grisel RJH, Staffhorst RWHM, Fichtinger-Schepman AMJ, Reedijk J, et al. The interaction of the anti-cancer drug cisplatin with phospholipids is specific for negatively charged phospholipids and takes place at low chloride ion concentration. Biochim Biophys Acta - Biomembr 1996; 1283: 60-6. doi: 10.1016/0005-2736(96)00080-6 Speelmans G Sips WHHM Grisel RJH Staffhorst RWHM Fichtinger-Schepman AMJ Reedijk J et al The interaction of the anti-cancer drug cisplatin with phospholipids is specific for negatively charged phospholipids and takes place at low chloride ion concentration Biochim Biophys Acta - Biomembr 1996 1283 60 6 10.1016/0005-2736(96)00080-68765095Open DOISearch in Google Scholar