Evaluation of toxic effects of chemotherapy in lung malignancies on cerebral white matter using diffusion tensor imaging
Article Category: Research Article
Published Online: May 04, 2022
Page range: 150 - 155
Received: Dec 02, 2021
Accepted: Mar 18, 2022
DOI: https://doi.org/10.2478/raon-2022-0017
Keywords
© 2022 Sinem Aydin, Tarik Demir, Haci Mehmet Turk, Dilek Hacer Cesme, Altay Aliyev, Mehmet Ali Gultekin, Temel Fatih Yilmaz, Alpay Alkan, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Background
Non-small cell lung cancer (NSCLC) is a leading cause of morbidity and mortality. Carboplatin and cisplatin based regimens are used in the treatment of NSCLC. The aim of the study was to find out whether there is a difference in white matter (WM) changes between two platinum-based chemotherapy agents using diffusion tensor imaging (DTI).
Patients and methods
25 patients who received chemotherapy for NSCLC and 27 age-matched healthy controls were enrolled in the study. Fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD) and radial diffusivity (RD) values of the study population were measured from 11 regions of interest in pre-chemotherapy and post-chemotherapy MRI data.
Results
Cisplatin group showed a significant decrease in the FA of the inferior longitudinal fasciculus (
Conclusions
The findings of the study suggest that subtle effects of chemotherapy detectable with DTI may emerge after the treatment. In addition, carboplatin regimen may have more impact on WM than cisplatin regimen.