Open Access

Diagnostic performance of apparent diffusion coefficient values for the differentiation of intrahepatic cholangiocarcinoma from gastrointestinal adenocarcinoma liver metastases

Temel Fatih Yilmaz
Temel Fatih Yilmaz
, 
Mehmet Ali Gultekin
Mehmet Ali Gultekin
, 
Hacı Mehmet Turk
Hacı Mehmet Turk
, 
Mehmet Besiroglu
Mehmet Besiroglu
, 
Dilek Hacer Cesme
Dilek Hacer Cesme
, 
Melih Simsek
Melih Simsek
, 
Alpay Alkan
Alpay Alkan
 and 
Huseyin Toprak
Huseyin Toprak
   | Dec 22, 2021
Radiology and Oncology's Cover Image
About this article
Previous Article
Next Article
Cite
Article Category: Research Article
Published Online: Dec 22, 2021
Page range: 54 - 59
Received: Jul 29, 2021
Accepted: Nov 04, 2021
DOI: https://doi.org/10.2478/raon-2021-0052
© 2022 Temel Fatih Yilmaz, Mehmet Ali Gultekin, Hacı Mehmet Turk, Mehmet Besiroglu, Dilek Hacer Cesme, Melih Simsek, Alpay Alkan, Huseyin Toprak, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Flow-chart of the study showing the exclusion criteria of the patients.
Flow-chart of the study showing the exclusion criteria of the patients.

Figure 2

59-year-old male with liver metastases due to colorectal adenocarcinoma. Contrast-enhanced axial T1-weighted (T1W) (A), diffusion weighted image (DWI) obtained at b value of 800 s/mm2 (B) and apparent diffusion coefficient (ADC) maps (C) with free hand ROI placement technique.
59-year-old male with liver metastases due to colorectal adenocarcinoma. Contrast-enhanced axial T1-weighted (T1W) (A), diffusion weighted image (DWI) obtained at b value of 800 s/mm2 (B) and apparent diffusion coefficient (ADC) maps (C) with free hand ROI placement technique.

Figure 3

58-year-old female with an expansile liver mass with central hypovascular fibrous stroma and peripheral contrast enhancement on contrastenhanced axial T1-weighted (T1W) (A) images. diffusion weighted image (DWI) obtained at b value of 800 s/mm2 (B) and apparent diffusion coefficient (ADC) maps (C) with region of interests (ROI) placement with three different contrast enhancing area for calculating ADCmean values.
58-year-old female with an expansile liver mass with central hypovascular fibrous stroma and peripheral contrast enhancement on contrastenhanced axial T1-weighted (T1W) (A) images. diffusion weighted image (DWI) obtained at b value of 800 s/mm2 (B) and apparent diffusion coefficient (ADC) maps (C) with region of interests (ROI) placement with three different contrast enhancing area for calculating ADCmean values.

Figure 4

Mean apparent diffusion coefficient (ADCmean) values of liver metastases of gastrointestinal system adenocarcinomas and intrahepatic cholangiocarcinoma (IHCC).
Mean apparent diffusion coefficient (ADCmean) values of liver metastases of gastrointestinal system adenocarcinomas and intrahepatic cholangiocarcinoma (IHCC).

Figure 5

Receiver operating characteristic curve of the apparent diffusion coefficient (ADC) mean values.
Receiver operating characteristic curve of the apparent diffusion coefficient (ADC) mean values.

Apparent diffusion coefficient (ADC) values of intrahepatic cholangiocarcinoma (IHCC) and gastrointestinal system (GIS) liver metastases

Patient Groups ADC x 10-6mm/sn2 (median, IQR)
IHCC (1293.0), (1422.0–951.75)
GIS metastases (861.0), (1053.0–695.0)

Univariate analysis of patient characteristics for gastrointestinal system (GIS) liver metastases and intrahepatic cholangiocarcinoma (IHCC)

Patient characteristics Number of patients (n = 63) IHCC (n = 10) Liver metastases (n = 53) P value
Age (years) 61.4 ± 9.93 62.50 ± 13.49 61.15 ± 9.18 0.679
Gender < 0.001
Male 35 2 33
Female 28 8 20
Diameter Location (mm) 47 ± 31.27 82.70 ± 28.58 40.26 ± 27 < < 0.001 0.001
Right lobe 24 2 38
Left lobe 43 8 15
eISSN:
1581-3207
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
Journal RSS Feed