<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_raon-2021-0052_s_006">
<h3>Background</h3>
<p>We aimed to investigate whether there is a difference between intrahepatic cholangiocarcinoma (IHCC) and liver metastases of gastrointestinal system (GIS) adenocarcinoma in terms of apparent diffusion coefficient (ADC) values.</p>
</sec>
<sec id="j_raon-2021-0052_s_007">
<h3>Patients and methods</h3>
<p>From January 2018 to January 2020, we retrospectively examined 64 consecutive patients with liver metastases due to gastrointestinal system adenocarcinomas and 13 consecutive IHCC in our hospital’s medical records. After exclusions, fifty-three patients with 53 liver metastases and 10 IHCC were included in our study. We divided the patients into two groups as IHCC and liver metastases of GIS adenocarcinoma. For mean apparent diffusion coefficient (ADC<sub>mean</sub>) values, the region of interests (ROI) was placed in solid portions of the lesions. ADC<sub>mean</sub> values of groups were compared.</p>
</sec>
<sec id="j_raon-2021-0052_s_008">
<h3>Results</h3>
<p>The mean age of IHCC group was 62.50 ± 13.49 and mean age of metastases group was 61.15 ± 9.18. ADC<sub>mean</sub> values were significantly higher in the IHCC group compared to the metastatic group (p &lt; 0.001). ROC curves method showed high diagnostic accuracy (AUC = 0.879) with cut-off value of &lt; 1178 x 10<sup>-6</sup> mm<sup><xref ref-type="bibr" rid="j_raon-2021-0052_ref_002">2</xref></sup>/s for ADC<sub>mean</sub> (Sensitivity = 90.57, Specificity = 70.0, positive predictive value [PPV] = 94.1, negative predictive value [NPV] = 58.3) in differentiating adenocarcinoma metastases from IHCC.</p>
</sec>
<sec id="j_raon-2021-0052_s_009">
<h3>Conclusions</h3>
<p>The present study results suggest that ADC values have a potential role for differentiation between IHCC and GIS adenocarcinoma liver metastases which may be valuable for patient management.</p>
</sec>
</abstract>

Background
We aimed to investigate whether there is a difference between intrahepatic cholangiocarcinoma (IHCC) and liver metastases of gastrointestinal system (GIS) adenocarcinoma in terms of apparent diffusion coefficient (ADC) values.


Patients and methods
From January 2018 to January 2020, we retrospectively examined 64 consecutive patients with liver metastases due to gastrointestinal system adenocarcinomas and 13 consecutive IHCC in our hospital’s medical records. After exclusions, fifty-three patients with 53 liver metastases and 10 IHCC were included in our study. We divided the patients into two groups as IHCC and liver metastases of GIS adenocarcinoma. For mean apparent diffusion coefficient (ADCmean) values, the region of interests (ROI) was placed in solid portions of the lesions. ADCmean values of groups were compared.


Results
The mean age of IHCC group was 62.50 ± 13.49 and mean age of metastases group was 61.15 ± 9.18. ADCmean values were significantly higher in the IHCC group compared to the metastatic group (p < 0.001). ROC curves method showed high diagnostic accuracy (AUC = 0.879) with cut-off value of < 1178 x 10-6 mm2/s for ADCmean (Sensitivity = 90.57, Specificity = 70.0, positive predictive value [PPV] = 94.1, negative predictive value [NPV] = 58.3) in differentiating adenocarcinoma metastases from IHCC.


Conclusions
The present study results suggest that ADC values have a potential role for differentiation between IHCC and GIS adenocarcinoma liver metastases which may be valuable for patient management.

Diagnostic performance of apparent diffusion coefficient values for the differentiation of intrahepatic cholangiocarcinoma from gastrointestinal adenocarcinoma liver metastases

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Background
We aimed to investigate whether there is a difference between intrahepatic cholangiocarcinoma (IHCC) and liver metastases of gastrointestinal system...

Diagnostic performance of apparent diffusion coefficient values for the differentiation of intrahepatic cholangiocarcinoma from gastrointestinal adenocarcinoma liver metastases

Article Category: Research Article

Published Online: Dec 22, 2021

Page range: 54 - 59

Received: Jul 29, 2021

Accepted: Nov 04, 2021

DOI: https://doi.org/10.2478/raon-2021-0052

© 2022 Temel Fatih Yilmaz, Mehmet Ali Gultekin, Hacı Mehmet Turk, Mehmet Besiroglu, Dilek Hacer Cesme, Melih Simsek, Alpay Alkan, Huseyin Toprak, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.