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Radiotherapy-associated angiosarcoma in the breast reconstructed by autologous free-flap and treated with electrochemotherapy

Romi Cencelj-Arnez

Romi Cencelj-Arnez

  • Department of Surgical Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
  • Faculty of Medicine, University of LjubljanaLjubljana, Slovenia
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Cencelj-Arnez, Romi
, 
Jerica Novak

Jerica Novak

  • Department of Surgical Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
  • Faculty of Medicine, University of LjubljanaLjubljana, Slovenia
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Novak, Jerica
, 
Andreja Klevisar Ivancic

Andreja Klevisar Ivancic

Department of Pathology, Institute of Oncology LjubljanaLjubljana, Slovenia
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Klevisar Ivancic, Andreja
, 
Masa Bosnjak

Masa Bosnjak

Department of Experimental Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
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Bosnjak, Masa
, 
Maja Cemazar

Maja Cemazar

  • Department of Experimental Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
  • University of Primorska, Faculty of Health SciencesIzola, Slovenia
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Cemazar, Maja
 and 
Marko Snoj

Marko Snoj

  • Department of Surgical Oncology, Institute of Oncology LjubljanaLjubljana, Slovenia
  • Faculty of Medicine, University of LjubljanaLjubljana, Slovenia
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Snoj, Marko
  
Dec 29, 2020
Radiotherapy-associated angiosarcoma in the breast reconstructed by autologous free-flap and treated with electrochemotherapy's Cover Image
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Article Category: Research Article
Published Online: Dec 29, 2020
Page range: 77 - 81
DOI: https://doi.org/10.2478/raon-2020-0074
Keywords
© 2021 Romi Cencelj-Arnez, Jerica Novak, Andreja Klevisar Ivancic, Masa Bosnjak, Maja Cemazar, Marko Snoj, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Clinical presentation of patient with angiosarcoma of right reconstructed breast.
Clinical presentation of patient with angiosarcoma of right reconstructed breast.

Figure 2

Pathologic hematoxylin and eosin (HE) specimen showing radiotherapy-associated angiosarcoma (RAA) involving dermis.
Pathologic hematoxylin and eosin (HE) specimen showing radiotherapy-associated angiosarcoma (RAA) involving dermis.

Figure 3

Amplification of the MYC oncogene was confirmed using FISH method on tumor specimen.
Amplification of the MYC oncogene was confirmed using FISH method on tumor specimen.

Figure 4

Treatment with electrochemotherapy. (A) Just before the treatment nodules were marked for evaluation; (B) 1 month after the treatment all nodules were in complete response.
Treatment with electrochemotherapy. (A) Just before the treatment nodules were marked for evaluation; (B) 1 month after the treatment all nodules were in complete response.

Case reports with radiotherapy-associated angiosarcoma (RAA) after autologous breast reconstruction

First authorYear publishedCase #Years after RTType of cancer surgeryType of breast reconstruction
Hanasono et al.4200516mastectomyDIEP flap
Aljarrah et al.5201426mastectomyTRAM flap
Yip et al.6201935mastectomy and axillary lymph node dissectionLD flap
Yip et al.62019410mastectomy and axillary lymph node dissectionDIEP flap
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Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
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