Mortality risk of hypoxaemic acute respiratory failure among Indonesians: A systematic review and meta-analysis

1. Scala R, Heunks L. Highlights in acute respiratory failure. European Respiratory Review. 2018;27(147): 180008. doi:10.1183/16000617.0008-2018 Scala R Heunks L. Highlights in acute respiratory failure . European Respiratory Review . 2018 ; 27 ( 147 ): 180008 . 10.1183/16000617.0008-2018 Open DOISearch in Google Scholar

2. Summers C, Todd RS, Vercruysse GA, Moore FA. Acute respiratory failure. In: Perioperative medicine [Internet]. Elsevier; 2022 [cited 2025 Mar 30]. p.576–586. Available from: https://linking-hub.elsevier.com/retrieve/pii/B9780323567244000393 Summers C Todd RS Vercruysse GA Moore FA. Acute respiratory failure . In: Perioperative medicine [Internet]. Elsevier ; 2022 [cited 2025 Mar 30 ]. p. 576 – 586 . Available from: https://linking-hub.elsevier.com/retrieve/pii/B9780323567244000393 Search in Google Scholar

3. Mirabile VS, Shebl E, Sankari A, Burns B. Respiratory failure in adults. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526127/ Mirabile VS Shebl E Sankari A Burns B. Respiratory failure in adults . In: StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing ; 2023 . Available from: https://www.ncbi.nlm.nih.gov/books/NBK526127/ Search in Google Scholar

4. Kempker JA, Abril MK, Chen Y, Kramer MR, Waller LA, Martin GS. The epidemiology of respiratory failure in the United States 2002–2017: a serial cross-sectional study. Critical Care Explorations. 2020;2(6): e0128. doi:10.1097/CCE.0000000000000128 Kempker JA Abril MK Chen Y Kramer MR Waller LA Martin GS. The epidemiology of respiratory failure in the United States 2002–2017: a serial cross-sectional study . Critical Care Explorations . 2020 ; 2 ( 6 ): e0128 . 10.1097/CCE.0000000000000128 Open DOISearch in Google Scholar

5. Woodhead M, Welch CA, Harrison DA, Bellingan G, Ayres JG. Community-acquired pneumonia on the intensive care unit: secondary analysis of 17,869 cases in the ICNARC Case Mix Programme Database. Critical Care (London, England). 2006;10(Suppl 2): S1. doi:10.1186/cc4927 Woodhead M Welch CA Harrison DA Bellingan G Ayres JG. Community-acquired pneumonia on the intensive care unit: secondary analysis of 17,869 cases in the ICNARC Case Mix Programme Database . Critical Care (London, England) . 2006 ; 10 ( Suppl 2 ): S1 . 10.1186/cc4927 Open DOISearch in Google Scholar

6. Gupta D, Keogh B, Chung KF, Ayres JG, Harrison DA, Goldfrad C, et al. Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database. Critical Care (London, England). 2004;8(2): R112–R121. doi:10.1186/cc2835 Gupta D Keogh B Chung KF Ayres JG Harrison DA Goldfrad C Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database . Critical Care (London, England) . 2004 ; 8 ( 2 ): R112 – R121 . 10.1186/cc2835 Open DOISearch in Google Scholar

7. Patil S, Krishnan J, Lechtzin N, Diette G. In-hospital mortality following acute exacerbations of chronic obstructive pulmonary disease. Archives of Internal Medicine. 2003;163(10): 1180–1186. doi:10.1001/archinte.163.10.1180 Patil S Krishnan J Lechtzin N Diette G. In-hospital mortality following acute exacerbations of chronic obstructive pulmonary disease . Archives of Internal Medicine . 2003 ; 163 ( 10 ): 1180 – 1186 . 10.1001/archinte.163.10.1180 Open DOISearch in Google Scholar

8. Rasmin M, Elhidsi M, Yahya WS. Characteristics and outcome of acute respiratory failure patients: a cross-sectional study from the National Referral Hospital for respiratory diseases. Pneumologia. 2018;67(2): 77–81. https://scholar.ui.ac.id/en/publications/characteristics-and-outcome-of-acute-respiratory-failure-patients Rasmin M Elhidsi M Yahya WS. Characteristics and outcome of acute respiratory failure patients: a cross-sectional study from the National Referral Hospital for respiratory diseases . Pneumologia . 2018 ; 67 ( 2 ): 77 – 81 . https://scholar.ui.ac.id/en/publications/characteristics-and-outcome-of-acute-respiratory-failure-patients Search in Google Scholar

9. Munn Z, Moola S, Lisy K, Riitano D, Tufanaru C. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. International Journal of Evidence-Based Healthcare. 2015;13(3): 147–153. doi:10.1097/XEB.0000000000000054 Munn Z Moola S Lisy K Riitano D Tufanaru C. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data . International Journal of Evidence-Based Healthcare . 2015 ; 13 ( 3 ): 147 – 153 . 10.1097/XEB.0000000000000054 Open DOISearch in Google Scholar

10. Rasmin M, Elhidsi M, Yahya WS, Sutanto YS, Setijadi AR, Putra NPP, et al. Underlying diseases and in-hospital mortality of acute respiratory failure patients: Indonesian prospective cohort study. Journal of Natural Science, Biology and Medicine. 2021;12(1): 22–25. doi:10.4103/jnsbm.JNSBM_127_20 Rasmin M Elhidsi M Yahya WS Sutanto YS Setijadi AR Putra NPP Underlying diseases and in-hospital mortality of acute respiratory failure patients: Indonesian prospective cohort study . Journal of Natural Science, Biology and Medicine . 2021 ; 12 ( 1 ): 22 – 25 . 10.4103/jnsbm.JNSBM_127_20 Open DOISearch in Google Scholar

11. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical Research Ed.). 2021;372: n71. doi:10.1136/bmj.n71 Page MJ McKenzie JE Bossuyt PM Boutron I Hoffmann TC Mulrow CD The PRISMA 2020 statement: an updated guideline for reporting systematic reviews . BMJ (Clinical Research Ed.) . 2021 ; 372 : n71 . 10.1136/bmj.n71 Open DOISearch in Google Scholar

12. Borges Migliavaca C, Stein C, Colpani V, Barker TH, Munn Z, Falavigna M, et al. How are systematic reviews of prevalence conducted? A methodological study. BMC Medical Research Methodology. 2020;20(1): 96. doi:10.1186/s12874-020-00975-3 Borges Migliavaca C Stein C Colpani V Barker TH Munn Z Falavigna M How are systematic reviews of prevalence conducted? A methodological study . BMC Medical Research Methodology . 2020 ; 20 ( 1 ): 96 . 10.1186/s12874-020-00975-3 Open DOISearch in Google Scholar

13. Berkey C, Hoaglin D, Mosteller F, Colditz G. A random-effects regression model for meta-analysis. Statistics in Medicine. 1995;14: 395–411. doi:10.1002/sim.4780140406 Berkey C Hoaglin D Mosteller F Colditz G. A random-effects regression model for meta-analysis . Statistics in Medicine . 1995 ; 14 : 395 – 411 . 10.1002/sim.4780140406 Open DOISearch in Google Scholar

14. Nugrahani A, Fauzi L. Risiko Mortalitas Pasien COVID-19 (Studi Kohort Retrospektif di Rumah Sakit Rujukan COVID-19). HIGEIA (Journal of Public Health Research and Development). 2022;6(2): 260–265. doi:10.15294/higeia.v6i2.54427 Nugrahani A Fauzi L. Risiko Mortalitas Pasien COVID-19 (Studi Kohort Retrospektif di Rumah Sakit Rujukan COVID-19) . HIGEIA (Journal of Public Health Research and Development) . 2022 ; 6 ( 2 ): 260 – 265 . 10.15294/higeia.v6i2.54427 Open DOISearch in Google Scholar

15. Amin Z, Afifah H, Mamudi CO. Short-term survival of acute respiratory distress syndrome patients at a single tertiary referral centre in Indonesia. Acta Medica Indonesiana. 2016;48(4): 300–306. https://www.actamedindones.org/index.php/ijim/article/view/173 Amin Z Afifah H Mamudi CO. Short-term survival of acute respiratory distress syndrome patients at a single tertiary referral centre in Indonesia . Acta Medica Indonesiana . 2016 ; 48 ( 4 ): 300 – 306 . https://www.actamedindones.org/index.php/ijim/article/view/173 Search in Google Scholar

16. Elhidsi M, Rasmin M. Prasenohadi. In-hospital mortality of pulmonary tuberculosis with acute respiratory failure and related clinical risk factors. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. 2021;23: 100236. doi:10.1016/j. jctube.2021.100236 Elhidsi M Rasmin M. Prasenohadi. In-hospital mortality of pulmonary tuberculosis with acute respiratory failure and related clinical risk factors . Journal of Clinical Tuberculosis and Other Mycobacterial Diseases . 2021 ; 23 : 100236 . 10.1016/j.jctube.2021.100236 Open DOISearch in Google Scholar

17. Made Reditya Noviyani N, Bagus Gede Suparyatha I, Kanya Wati D, Nyoman Budi Hartawan I. Outcome comparison between pulmonary and extrapulmonary acute respiratory distress syndrome in pediatric intensive care unit. American Journal of Pediatrics. 2020;6(4): 442. doi:10.11648/j. ajp.20200604.19 Made Reditya Noviyani N Bagus Gede Suparyatha I Kanya Wati D Nyoman Budi Hartawan I. Outcome comparison between pulmonary and extrapulmonary acute respiratory distress syndrome in pediatric intensive care unit . American Journal of Pediatrics . 2020 ; 6 ( 4 ): 442 . 10.11648/j.ajp.20200604.19 Open DOISearch in Google Scholar

18. Nugraha PK, Utariani A, Setiawan P, Semedi BP. ROX index as a predictor of intubation risk and 28-day mortality in COVID-19 patients with acute respiratory distress syndrome. International Journal of Scientific Advances [Internet]. 2022 [cited 2025 Apr 1];3(1). Available from: https://www.ijscia. com/?p=8495 Nugraha PK Utariani A Setiawan P Semedi BP. ROX index as a predictor of intubation risk and 28-day mortality in COVID-19 patients with acute respiratory distress syndrome . International Journal of Scientific Advances [Internet]. 2022 [cited 2025 Apr 1 ]; 3 ( 1 ). Available from: https://www.ijscia.com/?p=8495 Search in Google Scholar

19. Valentania V, Somasetia DH, Hilmanto D, Setiabudi D, Nataprawira HMN. Modified PIRO (predisposition, insult, response, organ dysfunction) severity score as a predictor for mortality of children with pneumonia in Hasan Sadikin Hospital, Bandung, Indonesia. Multidisciplinary Respiratory Medicine [Internet]. 2021 Mar 10 [cited 2025 Apr 1];16. Available from: https://mrmjournal.org/index.php/mrm/article/view/735 Valentania V Somasetia DH Hilmanto D Setiabudi D Nataprawira HMN. Modified PIRO (predisposition, insult, response, organ dysfunction) severity score as a predictor for mortality of children with pneumonia in Hasan Sadikin Hospital, Bandung, Indonesia . Multidisciplinary Respiratory Medicine [Internet]. 2021 Mar 10 [cited 2025 Apr 1 ]; 16 . Available from: https://mrmjournal.org/index.php/mrm/article/view/735 Search in Google Scholar

20. Cucinotta D, Vanelli M. WHO declares COVID-19 a pandemic. Acta Biomedica Atenei Parmensis. 2020;91(1): 157–160. doi:10.23750/abm.v91i1.9397 Cucinotta D Vanelli M. WHO declares COVID-19 a pandemic . Acta Biomedica Atenei Parmensis . 2020 ; 91 ( 1 ): 157 – 160 . 10.23750/abm.v91i1.9397 Open DOISearch in Google Scholar

21. Bhutta BS, Alghoula F, Berim I. Hypoxia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482316/ Bhutta BS Alghoula F Berim I. Hypoxia . In: StatPearls [Internet] . Treasure Island (FL) : StatPearls Publishing ; 2024 . Available from: https://www.ncbi.nlm.nih.gov/books/NBK482316/ Search in Google Scholar

22. Sarkar M, Niranjan N, Banyal P. Mechanisms of hypoxemia. Lung India. 2017;34(1): 47. doi:10.4103/0970-2113.197116 Sarkar M Niranjan N Banyal P. Mechanisms of hypoxemia . Lung India . 2017 ; 34 ( 1 ): 47 . 10.4103/0970-2113.197116 Open DOISearch in Google Scholar

23. Swenson KE, Hardin CC. Pathophysiology of hypoxemia in COVID-19 lung disease. Clinics in Chest Medicine. 2023;44(2): 239–248. doi:10.1016/j.ccm.2022.11.007 Swenson KE Hardin CC. Pathophysiology of hypoxemia in COVID-19 lung disease . Clinics in Chest Medicine . 2023 ; 44 ( 2 ): 239 – 248 . 10.1016/j.ccm.2022.11.007 Open DOISearch in Google Scholar

24. Tipre DN, Cidon M, Moats RA. Imaging pulmonary blood vessels and ventilation-perfusion mismatch in COVID-19. Molecular Imaging and Biology. 2022;24(4): 526–536. doi:10.1007/s11307-021-01700-2 Tipre DN Cidon M Moats RA. Imaging pulmonary blood vessels and ventilation-perfusion mismatch in COVID-19 . Molecular Imaging and Biology . 2022 ; 24 ( 4 ): 526 – 536 . 10.1007/s11307-021-01700-2 Open DOISearch in Google Scholar

25. Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315(8): 788. doi:10.1001/jama.2016.0291 Bellani G Laffey JG Pham T Fan E Brochard L Esteban A Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries . JAMA . 2016 ; 315 ( 8 ): 788 . 10.1001/jama.2016.0291 Open DOISearch in Google Scholar

26. Karagiannidis C, Krause F, Bentlage C, Wolff J, Bein T, Windisch W, et al. In-hospital mortality, comorbidities, and costs of one million mechanically ventilated patients in Germany: a nationwide observational study before, during, and after the COVID-19 pandemic. The Lancet Regional Health - Europe. 2024;42: 100954. doi:10.1016/j.lanepe.2024.100954 Karagiannidis C Krause F Bentlage C Wolff J Bein T Windisch W In-hospital mortality, comorbidities, and costs of one million mechanically ventilated patients in Germany: a nationwide observational study before, during, and after the COVID-19 pandemic . The Lancet Regional Health - Europe . 2024 ; 42 : 100954 . 10.1016/j.lanepe.2024.100954 Open DOISearch in Google Scholar

27. Siddiqui S, Puthucheary Z, Phua J, Ho B, Tan J, Chuin S, et al. National survey of outcomes and practices in acute respiratory distress syndrome in Singapore. Lazzeri C, editor. PLoS One. 2017;12(6): e0179343. doi:10.1371/journal.pone.0179343 Siddiqui S Puthucheary Z Phua J Ho B Tan J Chuin S National survey of outcomes and practices in acute respiratory distress syndrome in Singapore . Lazzeri C editor. PLoS One . 2017 ; 12 ( 6 ): e0179343 . 10.1371/journal.pone.0179343 Open DOISearch in Google Scholar

28. Chen W, Chen YY, Tsai CF, Chen SC, Lin MS, Ware LB, et al. Incidence and outcomes of acute respiratory distress syndrome: a nationwide registry-based study in Taiwan, 1997 to 2011. Medicine. 2015;94(43): e1849. doi:10.1097/MD.0000000000001849 Chen W Chen YY Tsai CF Chen SC Lin MS Ware LB Incidence and outcomes of acute respiratory distress syndrome: a nationwide registry-based study in Taiwan, 1997 to 2011 . Medicine . 2015 ; 94 ( 43 ): e1849 . 10.1097/MD.0000000000001849 Open DOISearch in Google Scholar

29. Parcha V, Kalra R, Bhatt SP, Berra L, Arora G, Arora P. Trends and geographic variation in acute respiratory failure and ARDS mortality in the United States. Chest. 2021;159(4): 1460–1472. doi:10.1016/j.chest.2020.10.042 Parcha V Kalra R Bhatt SP Berra L Arora G Arora P. Trends and geographic variation in acute respiratory failure and ARDS mortality in the United States . Chest . 2021 ; 159 ( 4 ): 1460 – 1472 . 10.1016/j.chest.2020.10.042 Open DOISearch in Google Scholar

30. Xu H, Sheng S, Luo W, Xu X, Zhang Z. Acute respiratory distress syndrome heterogeneity and the septic ARDS subgroup. Frontiers in Immunology. 2023;14: 1277161. doi:10.3389/fimmu.2023.1277161 Xu H Sheng S Luo W Xu X Zhang Z. Acute respiratory distress syndrome heterogeneity and the septic ARDS subgroup . Frontiers in Immunology . 2023 ; 14 : 1277161 . 10.3389/fimmu.2023.1277161 Open DOISearch in Google Scholar

31. Crimi C, Murphy P, Patout M, Sayas J, Winck JC. Lessons from COVID-19 in the management of acute respiratory failure. Breathe (Sheffield, England). 2023;19(1): 230035. doi:10.1183/20734735.0035-2023 Crimi C Murphy P Patout M Sayas J Winck JC. Lessons from COVID-19 in the management of acute respiratory failure . Breathe (Sheffield, England) . 2023 ; 19 ( 1 ): 230035 . 10.1183/20734735.0035-2023 Open DOISearch in Google Scholar

32. Bonnesen B, Jensen JS, Jeschke KN, Mathioudakis AG, Corlateanu A, Hansen EF, et al. Management of COVID-19-associated acute respiratory failure with alternatives to invasive mechanical ventilation: high-flow oxygen, continuous positive airway pressure, and noninvasive ventilation. Diagnostics (Basel, Switzerland). 2021;11(12): 2259. doi:10.3390/diagnostics11122259 Bonnesen B Jensen JS Jeschke KN Mathioudakis AG Corlateanu A Hansen EF Management of COVID-19-associated acute respiratory failure with alternatives to invasive mechanical ventilation: high-flow oxygen, continuous positive airway pressure, and noninvasive ventilation . Diagnostics (Basel, Switzerland) . 2021 ; 11 ( 12 ): 2259 . 10.3390/diagnostics11122259 Open DOISearch in Google Scholar

33. Fujishima S. Guideline-based management of acute respiratory failure and acute respiratory distress syndrome. Journal of Intensive Care. 2023;11(1): 10. doi:10.1186/s40560-023-00658-3 Fujishima S. Guideline-based management of acute respiratory failure and acute respiratory distress syndrome . Journal of Intensive Care . 2023 ; 11 ( 1 ): 10 . 10.1186/s40560-023-00658-3 Open DOISearch in Google Scholar

34. Bhatt N, Nepal S, Pinder RJ, Lucero-Prisno DE, Budhathoki SS. Challenges of hospital oxygen management during the COVID-19 pandemic in rural Nepal. The American Journal of Tropical Medicine and Hygiene. 2022;106(4): 997–999. doi:10.4269/ajtmh.21-0669 Bhatt N Nepal S Pinder RJ Lucero-Prisno DE Budhathoki SS. Challenges of hospital oxygen management during the COVID-19 pandemic in rural Nepal . The American Journal of Tropical Medicine and Hygiene . 2022 ; 106 ( 4 ): 997 – 999 . 10.4269/ajtmh.21-0669 Open DOISearch in Google Scholar

35. Graham HR, King C, Rahman AE, Kitutu FE, Greenslade L, Aqeel M, et al. Reducing global inequities in medical oxygen access: the Lancet Global Health Commission on medical oxygen security. The Lancet Global Health. 2025;13(3): e528–e584. doi:10.1016/S2214-109X(24)00496-0Supplementary Materials Graham HR King C Rahman AE Kitutu FE Greenslade L Aqeel M Reducing global inequities in medical oxygen access: the Lancet Global Health Commission on medical oxygen security . The Lancet Global Health . 2025 ; 13 ( 3 ): e528 – e584 . 10.1016/S2214-109X(24)00496-0Supplementary Materials Open DOISearch in Google Scholar