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Unusual cause of bronchiolitis obliterans in an immunosuppressed patient

Ana-Lavinia Neacșu

Ana-Lavinia Neacșu

“Marius Nasta” Institute of PneumophtisiologyBucharest, Romania
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Neacșu, Ana-Lavinia
, 
Inna Dencheva Ruseva

Inna Dencheva Ruseva

“Marius Nasta” Institute of PneumophtisiologyBucharest, Romania
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Ruseva, Inna Dencheva
, 
Ionuț Hallabrin

Ionuț Hallabrin

“Marius Nasta” Institute of PneumophtisiologyBucharest, Romania
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Hallabrin, Ionuț
, 
Cătălina Ene

Cătălina Ene

  • “Marius Nasta” Institute of PneumophtisiologyBucharest, Romania
  • “Carol Davila” University of Medicine and PharmacyBucharest, Romania
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Ene, Cătălina
, 
Diana Leonte

Diana Leonte

“Marius Nasta” Institute of PneumophtisiologyBucharest, Romania
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Leonte, Diana
 and 
Claudia Toma

Claudia Toma

  • “Marius Nasta” Institute of PneumophtisiologyBucharest, Romania
  • “Carol Davila” University of Medicine and PharmacyBucharest, Romania
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Toma, Claudia
  
May 02, 2024
Unusual cause of bronchiolitis obliterans in an immunosuppressed patient's Cover Image
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Article Category: Case Report
Published Online: May 02, 2024
Page range: 108 - 112
DOI: https://doi.org/10.2478/pneum-2023-0031
Keywords
© 2022 Ana-Lavinia Neacșu et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

Chest X-ray aspect of multiple areas of condensation distributed diffusely bilaterally, normal costodiaphragmatic angles.
Chest X-ray aspect of multiple areas of condensation distributed diffusely bilaterally, normal costodiaphragmatic angles.

Figure 2.

CT scan of the chest aspect of micronodular and nodular lesions, some with the tendency of excavation and hydroaeric level present and a polyseptate lesion in the right lower lobe.
CT scan of the chest aspect of micronodular and nodular lesions, some with the tendency of excavation and hydroaeric level present and a polyseptate lesion in the right lower lobe.

Figure 3.

CT-guided transthoracic needle biopsy fragments from the pseudotumoral proliferation in the right lower lobe.
CT-guided transthoracic needle biopsy fragments from the pseudotumoral proliferation in the right lower lobe.

Figure 4.

Pulmonary parenchymal tissue structure altered by diffuse interstitial inflammatory infiltrate associated with ductal and endo-alveolar areas of fibro-granular proliferation (HE staining, x 200).
Pulmonary parenchymal tissue structure altered by diffuse interstitial inflammatory infiltrate associated with ductal and endo-alveolar areas of fibro-granular proliferation (HE staining, x 200).

Figure 5.

Multiple Masson bodies, difuse interstitial lymphocytic inflammatory infiltrate (HE staining, x 200).
Multiple Masson bodies, difuse interstitial lymphocytic inflammatory infiltrate (HE staining, x 200).

Figure 6.

CT scan of the chest highlighting the almost complete resolution of the nodular and micronodular lesions.
CT scan of the chest highlighting the almost complete resolution of the nodular and micronodular lesions.

Functional respiratory tests indicating lower values of FEV1, FVC and FEV1/FVC <70%_

Functional parameter Numerical value %
FVC 3.28 L 74.5
FEV1 2.23 L 62.3
FEV1/FVC - 68.16%
MEF50 1.67 L 35.1
DLCO 5.08 50.3
KCOc 0.93 62.1
Language:
English
Publication timeframe:
Volume Open
Journal Subjects:
Medicine, Clinical Medicine, Clinical Medicine, other, Internal Medicine, Pneumology
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