<abstract xmlns="http://www.w3.org/1999/xhtml">
<p>A novel series of 1,3,4-oxadiazole derivatives of mefenamic acid was obtained by reacting hydrazones of mefenamic acid with anhydrous acetic anhydride. The mefenamic hydrazones were obtained by reacting different substituted aldehydes with mefenamic acid hydrazide. All the compounds were characterized by spectral data and elemental analysis. Molecular docking studies of all the compounds were performed against COX-1/COX-2 enzymes. Compound <bold>4</bold> and compound <bold>10</bold> were found to have the highest potential to bind with COX-1 while compound <bold>3</bold>, compound <bold>6</bold>, and compound <bold>10</bold> were found to have the highest potential to bind with COX-2 enzyme.</p>
</abstract>

A novel series of 1,3,4-oxadiazole derivatives of mefenamic acid was obtained by reacting hydrazones of mefenamic acid with anhydrous acetic anhydride. The mefenamic hydrazones were obtained by reacting different substituted aldehydes with mefenamic acid hydrazide. All the compounds were characterized by spectral data and elemental analysis. Molecular docking studies of all the compounds were performed against COX-1/COX-2 enzymes. Compound 4 and compound 10 were found to have the highest potential to bind with COX-1 while compound 3, compound 6, and compound 10 were found to have the highest potential to bind with COX-2 enzyme.

Synthesis, characterization, and molecular modeling of novel 1,3,4-oxadiazole derivatives of mefenamic acid

Department of Pharmaceutical Chemistry, College of Pharmacy

Polish Journal of Chemical Technology

This work is licensed under the Creative Commons Attribution 4.0 International License.

A novel series of 1,3,4-oxadiazole derivatives of mefenamic acid was obtained by reacting hydrazones of mefenamic acid with anhydrous acetic anhydride. The...

Synthesis, characterization, and molecular modeling of novel 1,3,4-oxadiazole derivatives of mefenamic acid

Published Online: Apr 03, 2024

Page range: 102 - 112

DOI: https://doi.org/10.2478/pjct-2024-0016

Keywords
Mefenamic acid, 1,3,4-Oxadiazoles, Hydrazones, Molecular docking, COX-1/COX-2 enzymes

© 2024 Mashooq A. Bhat et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Synthesis, characterization, and molecular modeling of novel 1,3,4-oxadiazole derivatives of mefenamic acid

Published Online: Apr 03, 2024

Page range: 102 - 112

DOI: https://doi.org/10.2478/pjct-2024-0016

KeywordsMefenamic acid, 1,3,4-Oxadiazoles, Hydrazones, Molecular docking, COX-1/COX-2 enzymes

© 2024 Mashooq A. Bhat et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
Mefenamic acid, 1,3,4-Oxadiazoles, Hydrazones, Molecular docking, COX-1/COX-2 enzymes