<abstract xmlns="http://www.w3.org/1999/xhtml">The operation parameters for the supercritical carbon dioxide (ScCO2) evaporation method greatly affect the properties of the prepared drug-loaded micelles. In this study, the effects of those key parameters on the drug-loading content (LC) and drug entrapment efficiency (EE) are discussed. It is observed that EE and LC of the micelles are slightly increased with the enhancing temperature and the copolymer molecular ratio of hydrophilic/hydrophobic segment, while decreased with the enhancing ScCO2 evaporation rate. The pressure and volume ratio of ScCO2 to H2O are observed the optimum condition. In addition, the verification experiment is carried out under the obtained optimizing parameters. The prepared micelles exhibit relatively regular spherical shape and narrow size distribution with the EE and LC value of 70.7% and 14.1%, respectively.</abstract>

The operation parameters for the supercritical carbon dioxide (ScCO2) evaporation method greatly affect the properties of the prepared drug-loaded micelles. In this study, the effects of those key parameters on the drug-loading content (LC) and drug entrapment efficiency (EE) are discussed. It is observed that EE and LC of the micelles are slightly increased with the enhancing temperature and the copolymer molecular ratio of hydrophilic/hydrophobic segment, while decreased with the enhancing ScCO2 evaporation rate. The pressure and volume ratio of ScCO2 to H2O are observed the optimum condition. In addition, the verification experiment is carried out under the obtained optimizing parameters. The prepared micelles exhibit relatively regular spherical shape and narrow size distribution with the EE and LC value of 70.7% and 14.1%, respectively.

Effects of processing parameters on the properties of amphiphilic block copolymer micelles prepared by supercritical carbon dioxide evaporation method

School of Chemistry and Chemical Engineering

Joint Research Institute of Southeast University and Monash University

Polish Journal of Chemical Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The operation parameters for the supercritical carbon dioxide (ScCO2) evaporation method greatly affect the properties of the prepared drug-loaded micelles. In...

Effects of processing parameters on the properties of amphiphilic block copolymer micelles prepared by supercritical carbon dioxide evaporation method

Published Online: Apr 16, 2018

Page range: 81 - 86

DOI: https://doi.org/10.2478/pjct-2018-0012

Keywords
supercritical carbon dioxide, amphiphilic block copolymer, drug-loaded micelles, processing parameters, optimization

© 2018 Zhen Jiao et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects of processing parameters on the properties of amphiphilic block copolymer micelles prepared by supercritical carbon dioxide evaporation method

Published Online: Apr 16, 2018

Page range: 81 - 86

DOI: https://doi.org/10.2478/pjct-2018-0012

Keywordssupercritical carbon dioxide, amphiphilic block copolymer, drug-loaded micelles, processing parameters, optimization

© 2018 Zhen Jiao et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
supercritical carbon dioxide, amphiphilic block copolymer, drug-loaded micelles, processing parameters, optimization