<abstract xmlns="http://www.w3.org/1999/xhtml">

Background: Lambda-cyhalothrin (LCH) is a one of the type II synthetic pyrethroids which is widely used in veterinary medicine and in agriculture to protect crops from pest insects. In previous studies, there are few reports about the influence of pyrethroids on the liver and its damage. Analyzing numerous publications, nuclear factor-ĸB (NF-ĸB) and vascular endothelial growth factor 2 (VEGFR2) seem to be sensitive indicators of microdamages occurring at the cellular level in the liver. The aim of the study was to investigate the effect of subacute poisoning with LCH on the concentration of NFĸB and VEGFR2 in the livers.
Methods: The experiment was carried on 32 Albino Swiss mice (16 females and 16 males). The animals were divided into 4 groups. Controls received canola oil, the rest received LCH orally in oil at a dose of 2 mg/kg bw for 7 days. The NF-ĸB and VEGFR2 were mesuredin mice livers with ELISA kits. Results: The mean NF-ĸB concektration in control femals’ livers was 3.27ng/mL and after LCH it was 6.12ng/mL (p&lt;0.05). In control males it was 5.49ng/mL and it did not significantly differ after LCH when it was 5.27ng/mL. The mean VEGFR2 in control females was 84.28ng/mL and after LCH it was 173.81ng/mL (p&lt;0.05). In control males it was 170.61ng/mL and after LCH 170.06ng/mL.
Conclusion:The NF-ĸB and VEGFR2 can be used as markers of liver damage after subacute poisoning with LCH on female mice. Females are more sensitive to LCH than males.
</abstract>

Background: Lambda-cyhalothrin (LCH) is a one of the type II synthetic pyrethroids which is widely used in veterinary medicine and in agriculture to protect crops from pest insects. In previous studies, there are few reports about the influence of pyrethroids on the liver and its damage. Analyzing numerous publications, nuclear factor-ĸB (NF-ĸB) and vascular endothelial growth factor 2 (VEGFR2) seem to be sensitive indicators of microdamages occurring at the cellular level in the liver. The aim of the study was to investigate the effect of subacute poisoning with LCH on the concentration of NFĸB and VEGFR2 in the livers.
Methods: The experiment was carried on 32 Albino Swiss mice (16 females and 16 males). The animals were divided into 4 groups. Controls received canola oil, the rest received LCH orally in oil at a dose of 2 mg/kg bw for 7 days. The NF-ĸB and VEGFR2 were mesuredin mice livers with ELISA kits. Results: The mean NF-ĸB concektration in control femals’ livers was 3.27ng/mL and after LCH it was 6.12ng/mL (p<0.05). In control males it was 5.49ng/mL and it did not significantly differ after LCH when it was 5.27ng/mL. The mean VEGFR2 in control females was 84.28ng/mL and after LCH it was 173.81ng/mL (p<0.05). In control males it was 170.61ng/mL and after LCH 170.06ng/mL.
Conclusion:The NF-ĸB and VEGFR2 can be used as markers of liver damage after subacute poisoning with LCH on female mice. Females are more sensitive to LCH than males.

Effect of Lambda-Cyhalothrin - An Insecticide from the Group of Synthetic Pyrethroids - on the Concentrations of NF-ĸB and VEGFR2 in the Liver of Albino Swiss Mice as Markers of its Damage

Department of Obstetrics and Perinatology in Lublin

3rd Chair and Department of Gynecology in Lublin

Students’ Scientific Association at The Chair and Department of Hygiene

Team of Ophthalmology Departments, Mazowiecki Szpital Bródnowski in Warsaw

Chair and Department of Hygiene and Epidemiology

Department of Underwater Works Technology

Polish Hyperbaric Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background: Lambda-cyhalothrin (LCH) is a one of the type II synthetic pyrethroids which is widely used in veterinary medicine and in agriculture to protect...

Effect of Lambda-Cyhalothrin - An Insecticide from the Group of Synthetic Pyrethroids - on the Concentrations of NF-ĸB and VEGFR2 in the Liver of Albino Swiss Mice as Markers of its Damage

Published Online: Oct 15, 2022

Page range: 57 - 68

Received: Oct 23, 2020

Accepted: Feb 18, 2021

DOI: https://doi.org/10.2478/phr-2021-0011

Keywords
Lambda-cyhalothrin, nuclear factor-ĸB, vascular endothelial growth factor2, liver damage

© 2021 Łukasz Świerszcz et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effect of Lambda-Cyhalothrin - An Insecticide from the Group of Synthetic Pyrethroids - on the Concentrations of NF-ĸB and VEGFR2 in the Liver of Albino Swiss Mice as Markers of its Damage

Published Online: Oct 15, 2022

Page range: 57 - 68

Received: Oct 23, 2020

Accepted: Feb 18, 2021

DOI: https://doi.org/10.2478/phr-2021-0011

KeywordsLambda-cyhalothrin, nuclear factor-ĸB, vascular endothelial growth factor2, liver damage

© 2021 Łukasz Świerszcz et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Lambda-cyhalothrin, nuclear factor-ĸB, vascular endothelial growth factor2, liver damage