Improved body composition is associated with reduced steatosis in non-alcoholic fatty liver disease, a systematic review and meta-analysis of longitudinal studies

1 Younossi ZM, Golabi P, de Avila L, Paik JM, Srishord M, Fukui N, et al. The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis. Journal of Hepatology. (2019) 71(4):793-801. doi: 10.1016/j.jhep.2019.06.021 Search in Google Scholar

2 EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. Journal of Hepatology. (2016) 64(6):1388-402. doi: 10.1016/j.jhep.2015.11.004 Search in Google Scholar

3 Leoni S, Tovoli F, Napoli L, Serio I, Ferri S, Bolondi L. Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis. World J Gastroenterol. (2018) 24(30):3361-73. doi: 10.3748/wjg.v24.i30.3361 Search in Google Scholar

4 Sumida Y, Yoneda M. Current and future pharmacological therapies for NAFLD/NASH. J Gastroenterol. (2018) 53(3):362-76. doi: 10.1007/s00535-017-1415-1 Search in Google Scholar

5 Sheka AC, Adeyi O, Thompson J, Hameed B, Crawford PA, Ikramuddin S. Nonalcoholic Steatohepatitis: A Review. JAMA. (2020) 323(12):1175-83. doi: 10.1001/jama.2020.2298 Search in Google Scholar

6 Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A, Gra-Oramas B, Gonzalez-Fabian L, et al. Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis. Gastroenterology. (2015) 149(2):367-78.e5; quiz e14-5. doi: 10.1053/j.gastro.2015.04.005 Search in Google Scholar

7 Hallsworth K, Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R, et al. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut. (2011) 60(9):1278-83. doi: 10.1136/gut.2011.242073 Search in Google Scholar

8 Kabir M, Catalano KJ, Ananthnarayan S, Kim SP, Citters GWV, Dea MK, et al. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. American Journal of Physiology-Endocrinology and Metabolism. (2005) 288(2):E454-E61. doi: 10.1152/ajpendo.00203.2004 Search in Google Scholar

9 Cai C, Song X, Chen Y, Chen X, Yu C. Relationship between relative skeletal muscle mass and nonalcoholic fatty liver 14(1):115-26. doi: 10.1007/s12072-019-09964-1 Search in Google Scholar

10 Osaka T, Hashimoto YO, Takuro, Fukuda T, Yamazaki MH, Masahide, Fukui M. Reduction of Fat to Muscle Mass Ratio Is Associated with Improvement of Liver Stiness in Diabetic Patients with Non-Alcoholic Fatty Liver Disease. Journal of Clinical Medicine [Internet]. (2019; 8(12). Search in Google Scholar

11 Kim G, Lee S-E, Lee Y-B, Jun JE, Ahn J, Bae JC, et al. Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7-Year Longitudinal Study. Hepatology. (2018) 68(5):1755-68. doi: https://doi.org/10.1002/hep.30049 Search in Google Scholar

12 Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. (2021) 372:n71. doi: 10.1136/bmj.n71 Search in Google Scholar

13 Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane handbook for systematic reviews of interventions: John Wiley & Sons (2019). Search in Google Scholar

14 Hayden JA, van der Windt DA, Cartwright JL, Côté P, Bombardier C. Assessing bias in studies of prognostic factors. Ann Intern Med. (2013) 158(4):280-6. doi: 10.7326/0003-4819-158-4-201302190-00009 Search in Google Scholar

15 McGuinness LA, Higgins JPT. Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Research Synthesis Methods. (2020) n/a(n/a). doi: 10.1002/jrsm.1411 Search in Google Scholar

16 Harrer M, Cuijpers P, Furukawa TA, Ebert DD. Doing Meta-Analysis With R: A Hands-On Guide. 1st ed. Boca Raton, FL and London: Chapman & Hall/CRC Press (2021) Search in Google Scholar

17 Ratner B. The correlation coefficient: Its values range between +1/−1, or do they? Journal of Targeting, Measurement and Analysis for Marketing. (2009) 17(2):139-42. doi: 10.1057/jt.2009.5 Search in Google Scholar

18 Cuthbertson DJ, Shojaee-Moradie F, Sprung VS, Jones H, Pugh CJ, Richardson P, et al. Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease. Clin Sci (Lond). (2016) 130(2):93-104. doi: 10.1042/cs20150447 Search in Google Scholar

19 Charatcharoenwitthaya P, Kuljiratitikal K, Aksornchanya O, Chaiyasoot K, Bandidniyamanon W, Charatcharoenwitthaya N. Moderate-Intensity Aerobic vs Resistance Exercise and Dietary Modification in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Clinical Trial. Clinical and Translational Gastroenterology. (2021) 12(3). Integer in libero neque. Suspendisse tempor magna in tincidunt posuere. Cras gravida nisi erat, sed pretium metus condimentum non. Aenean condimentum lectus eget arcu placerat, in bibendum lorem venenatis. Search in Google Scholar

20 Houghton D, Thoma C, Hallsworth K, Cassidy S, Hardy T, Burt AD, et al. Exercise Reduces Liver Lipids and Visceral Adiposity in Patients With Nonalcoholic Steatohepatitis in a Randomized Controlled Trial. Clin Gastroenterol Hepatol. (2017) 15(1):96-102.e3. doi: 10.1016/j.cgh.2016.07.031 Search in Google Scholar

21 Keating SE, Hackett DA, Parker HM, O’Connor HT, Gerofi JA, Sainsbury A, et al. Effect of aerobic exercise training dose on liver fat and visceral adiposity. Journal of Hepatology. (2015) 63(1):174-82. doi: 10.1016/j.jhep.2015.02.022 Search in Google Scholar

22 Lee S, Kim KW, Lee J, Park T, Park HJ, Song GW, et al. Reduction of Visceral Adiposity as a Predictor for Resolution of Nonalcoholic Fatty Liver in Potential Living Liver Donors. Liver Transpl. (2021) 27(10):1424-31. doi: 10.1002/lt.26071 Search in Google Scholar

23 Kuchay MS, Martínez-Montoro JI, Choudhary NS, Fernández-García JC, Ramos-Molina B. Non-alcoholic fatty liver disease in lean and non-obese individuals: current and future challenges. Biomedicines. (2021) 9(10):1346. Search in Google Scholar

24 Kim D, Chung GE, Kwak M-S, Seo HB, Kang JH, Kim W, et al. Body Fat Distribution and Risk of Incident and Regressed Nonalcoholic Fatty Liver Disease. Clinical Gastroenterology and Hepatology. (2016) 14(1):132-8.e4. doi: 10.1016/j.cgh.2015.07.024 Search in Google Scholar

25 Pramfalk C, Pavlides M, Banerjee R, McNeil CA, Neubauer S, Karpe F, et al. Sex-Specific Differences in Hepatic Fat Oxidation and Synthesis May Explain the Higher Propensity for NAFLD in Men. The Journal of Clinical Endocrinology & Metabolism. (2015) 100(12):4425-33. doi: 10.1210/jc.2015-2649 Search in Google Scholar

26 Kenđel Jovanović G, Mrakovcic-Sutic I, Pavičić Žeželj S, Benjak Horvat I, Šuša L, Rahelić D, et al. Metabolic and Hepatic Effects of Energy-Reduced Anti-Inflammatory Diet in Younger Adults with Obesity. Canadian Journal of Gastroenterology and Hepatology. (2021) 2021:6649142. doi: 10.1155/2021/6649142 Search in Google Scholar

27 Nauli AM, Matin S. Why do men accumulate abdominal visceral fat? Frontiers in Physiology. (2019):1486. Search in Google Scholar

28 Villareal DT, Apovian CM, Kushner RF, Klein S. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res. (2005) 13(11):1849-63. doi: 10.1038/oby.2005.228 Search in Google Scholar

29 Ratziu V, Francque S, Sanyal A. Breakthroughs in therapies for NASH and remaining challenges. Journal of Hepatology. (2022) 76(6):1263-78. doi: 10.1016/j.jhep.2022.04.002 Search in Google Scholar

30 Hegyi P, Erőss B, Izbéki F, Párniczky A, Szentesi A. Accelerating the translational medicine cycle: the Academia Europaea pilot. Nat Med. (2021) 27(8):1317-9. doi: 10.1038/s41591-021-01458-8 Search in Google Scholar

31 Hegyi P, Petersen OH, Holgate S, Erőss B, Garami A, Szakács Z, et al. Academia Europaea Position Paper on Translational Medicine: The Cycle Model for Translating Scientific Results into Community Benefits. J Clin Med. (2020) 9(5). doi: 10.3390/jcm9051532 Search in Google Scholar