<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Urinary tract infections are the third most common infections in human medicine worldwide. Citrobacter species present a challenge to both clinicians and clinical microbiologists, due to various intrinsic and acquired resistance mechanisms. This study includes microbiological and resistance data on urine samples positive for Citrobacter spp. between January 1, 2008 and December 31, 2017 at the Department of Clinical Microbiology, University of Szeged. Citrobacter species represented 0.7% (n=129) of outpatient samples and 0.6% (n=138) of inpatient samples. Their higher prevalence at advanced age (> 60 years) is consistent with that reported in the literature, whereas the clinical origin (inpatient/outpatient) of the urine specimens did not influence their isolation rates. Overall, the highest levels of resistance were observed with ceftriaxone (29.8% and 47.5%), whereas in case of gentamicin (8.3% and 25.4%) and fosfomycin (9.3 and 13.8%), the lowest level of resistance was detected, respectively. As these pathogens may cause nosocomial epidemics (usually in vulnerable patients groups), close and continuous monitoring is required at both institutional and national level.</p></abstract>

Urinary tract infections are the third most common infections in human medicine worldwide. Citrobacter species present a challenge to both clinicians and clinical microbiologists, due to various intrinsic and acquired resistance mechanisms. This study includes microbiological and resistance data on urine samples positive for Citrobacter spp. between January 1, 2008 and December 31, 2017 at the Department of Clinical Microbiology, University of Szeged. Citrobacter species represented 0.7% (n=129) of outpatient samples and 0.6% (n=138) of inpatient samples. Their higher prevalence at advanced age (> 60 years) is consistent with that reported in the literature, whereas the clinical origin (inpatient/outpatient) of the urine specimens did not influence their isolation rates. Overall, the highest levels of resistance were observed with ceftriaxone (29.8% and 47.5%), whereas in case of gentamicin (8.3% and 25.4%) and fosfomycin (9.3 and 13.8%), the lowest level of resistance was detected, respectively. As these pathogens may cause nosocomial epidemics (usually in vulnerable patients groups), close and continuous monitoring is required at both institutional and national level.

Relevance of Citrobacter species in urinary tract infections: a 10 year surveillance study

Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy

Bulletin of Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Urinary tract infections are the third most common infections in human medicine worldwide. Citrobacter species present a challenge to both clinicians and...

Relevance of Citrobacter species in urinary tract infections: a 10 year surveillance study

Published Online: Dec 03, 2020

Page range: 9 - 15

Received: May 05, 2020

Accepted: Aug 13, 2020

DOI: https://doi.org/10.2478/orvtudert-2020-0002

Keywords
urinary tract infection; antibiotic; resistance; epidemiology; Citrobacter

© 2020 Gajdács Márió, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Relevance of Citrobacter species in urinary tract infections: a 10 year surveillance study

Published Online: Dec 03, 2020

Page range: 9 - 15

Received: May 05, 2020

Accepted: Aug 13, 2020

DOI: https://doi.org/10.2478/orvtudert-2020-0002

Keywordsurinary tract infection; antibiotic; resistance; epidemiology; Citrobacter

© 2020 Gajdács Márió, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
urinary tract infection; antibiotic; resistance; epidemiology; Citrobacter