<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. It can be applied to produce Bi-213 in a reusable generator or can be used alone as an agent for radiation therapy, in particular for targeted alpha therapy. However, the availability of Ac-225 for worldwide use, particularly in low- and middle-income countries, is limited. We present a feasibility study employing GATE, an open-source Monte Carlo simulation toolkit, on the production of Ac-225 from a neutron generator. This work suggests that a design consisting of three concentric cylinders, the innermost a Cf-252 neutron source, the middle nickel cylinder acting as a proton-producing target and the outer cylinder a RaCl<sub>2</sub> target may provide a feasible design outline for an Ac-225 generator.</p></abstract>

Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. It can be applied to produce Bi-213 in a reusable generator or can be used alone as an agent for radiation therapy, in particular for targeted alpha therapy. However, the availability of Ac-225 for worldwide use, particularly in low- and middle-income countries, is limited. We present a feasibility study employing GATE, an open-source Monte Carlo simulation toolkit, on the production of Ac-225 from a neutron generator. This work suggests that a design consisting of three concentric cylinders, the innermost a Cf-252 neutron source, the middle nickel cylinder acting as a proton-producing target and the outer cylinder a RaCl2 target may provide a feasible design outline for an Ac-225 generator.

Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies

Faculty of Engineering, Department of Nuclear Engineering

Center for Training & Radiation Prevention

Department of Medical Physics & Biomedical Engineering, Malet Place Engineering Building

Nukleonika

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. It can be applied to produce Bi-213 in a reusable generator or can be used...

Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies

Article Category: Original Paper

Published Online: Jun 08, 2021

Page range: 61 - 67

Received: Aug 18, 2020

Accepted: Apr 06, 2021

DOI: https://doi.org/10.2478/nuka-2021-0008

Keywords
Actinium-225, Radiopharmaceutical, Californium-252, Neutron source, (n,p) reaction

© 2021 Fouad A. Abolaban et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies

Article Category: Original Paper

Published Online: Jun 08, 2021

Page range: 61 - 67

Received: Aug 18, 2020

Accepted: Apr 06, 2021

DOI: https://doi.org/10.2478/nuka-2021-0008

KeywordsActinium-225, Radiopharmaceutical, Californium-252, Neutron source, (n,p) reaction

© 2021 Fouad A. Abolaban et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Actinium-225, Radiopharmaceutical, Californium-252, Neutron source, (n,p) reaction