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Design and fabrication of 125I seeds for brachytherapy using capillary-based microfluidic technique

Yuan Wang

Yuan Wang

University of Science and Technology of China, Department of Engineering and Applied PhysicsHe-Fei, P. R. China
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Wang, Yuan
, 
Miao Zhang

Miao Zhang

University of Science and Technology of China, Department of Engineering and Applied PhysicsHe-Fei, P. R. China
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Zhang, Miao
, 
Tong Song

Tong Song

University of Science and Technology of China, Department of Engineering and Applied PhysicsHe-Fei, P. R. China
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Song, Tong
 and 
Zhenqi Chang

Zhenqi Chang

University of Science and Technology of China, Department of Engineering and Applied PhysicsHe-Fei, P. R. China
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Chang, Zhenqi
  
Jun 08, 2021
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Article Category: Original Paper
Published Online: Jun 08, 2021
Page range: 55 - 60
Received: Mar 01, 2020
Accepted: May 07, 2020
DOI: https://doi.org/10.2478/nuka-2021-0007
Keywords
© 2021 Yuan Wang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

Schematic drawing of capillary-based microfluidic device for synthesis of core-shell microspheres. Inner/outer diameter of the outside capillary (1) is 255 μm/510 μm, and inner/outer diameter of the inner capillary (2) is 100 μm/167 μm.
Schematic drawing of capillary-based microfluidic device for synthesis of core-shell microspheres. Inner/outer diameter of the outside capillary (1) is 255 μm/510 μm, and inner/outer diameter of the inner capillary (2) is 100 μm/167 μm.

Fig. 2

(a1–a3) Formation of core-shell structure droplet, Q1 = 120 μL/min, Q2 = 3.75 μL/min, Q3 = 0.25 μL/min; (b) optical image of as-prepared 125I seeds.
(a1–a3) Formation of core-shell structure droplet, Q1 = 120 μL/min, Q2 = 3.75 μL/min, Q3 = 0.25 μL/min; (b) optical image of as-prepared 125I seeds.

Fig. 3

Optical images of 125I seeds with a various core diameter and the same overall diameter of 600 μm. (a) Core diameter of 400 μm, Q1 = 120 μL/min, Q2 = 3 μL/min, Q3 = 1 μL/min, the radioactivity of a single 125I-encapsulated microsphere was about 0.17 mCi; (b) core diameter of 200 μm, Q1 = 120 μL/min, Q2 = 3.83 μL/min, Q3 = 0.17 μL/min, the radioactivity of a single 125I-encapsulated microsphere was about 0.02 mCi.
Optical images of 125I seeds with a various core diameter and the same overall diameter of 600 μm. (a) Core diameter of 400 μm, Q1 = 120 μL/min, Q2 = 3 μL/min, Q3 = 1 μL/min, the radioactivity of a single 125I-encapsulated microsphere was about 0.17 mCi; (b) core diameter of 200 μm, Q1 = 120 μL/min, Q2 = 3.83 μL/min, Q3 = 0.17 μL/min, the radioactivity of a single 125I-encapsulated microsphere was about 0.02 mCi.

Fig. 4

Isodose curves of the 125I brachytherapy sources with different orientation of cores in the sources. Overall diameter of the 125I seeds was 600 μm, and core diameter was 300 μm. (a) Each seed of core and shell is of homocentricity. (b–d) Each seed of core and shell was of nonhomocentricity.
Isodose curves of the 125I brachytherapy sources with different orientation of cores in the sources. Overall diameter of the 125I seeds was 600 μm, and core diameter was 300 μm. (a) Each seed of core and shell is of homocentricity. (b–d) Each seed of core and shell was of nonhomocentricity.

Fig. 5

Isodose curves of the 125I brachytherapy sources with different core size under the same orientation in the source. Each seed diameter was 600 μm, and core diameter was (a) 150 μm, (b) 300 μm, (c) 400 μm, and (d) 500 μm.
Isodose curves of the 125I brachytherapy sources with different core size under the same orientation in the source. Each seed diameter was 600 μm, and core diameter was (a) 150 μm, (b) 300 μm, (c) 400 μm, and (d) 500 μm.

Fig. 6

Isodose curves of the 125I brachytherapy sources with a different orientation of the cores. Overall diameter of the 125I seeds was 600 μm, and the diameter of core was 500 μm.
Isodose curves of the 125I brachytherapy sources with a different orientation of the cores. Overall diameter of the 125I seeds was 600 μm, and the diameter of core was 500 μm.

Fig. 7

Optical image of a 125I brachytherapy source consisted of six 125I seeds within a glass tubing. The overall diameter of the seeds was 600 μm, and the diameter of core was 500 μm.
Optical image of a 125I brachytherapy source consisted of six 125I seeds within a glass tubing. The overall diameter of the seeds was 600 μm, and the diameter of core was 500 μm.
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