Nanofibrous membranes loaded with bupivacaine and carica papaya extract for pain management and wound healing in postoperative wounds

[1] Júnior EML, et al. Nile tilapia fish skin–based wound dressing improves pain and treatment-related costs of superficial partial-thickness burns: a phase III randomized controlled trial. Plast Reconstr Surg. 2021;147(5):1189–1198. doi: 10.1097/PRS.0000000000007895 Júnior EML Nile tilapia fish skin–based wound dressing improves pain and treatment-related costs of superficial partial-thickness burns: a phase III randomized controlled trial . Plast Reconstr Surg . 2021 ; 147 ( 5 ): 1189 – 1198 . doi: 10.1097/PRS.0000000000007895 Open DOISearch in Google Scholar

[2] Schiefer JL, et al. Comparison of wound healing and patient comfort in partial-thickness burn wounds treated with SUPRATHEL and epictehydro wound dressings. Int Wound J. 2022;19(4):782–790. doi: 10.1111/iwj.13674 Schiefer JL Comparison of wound healing and patient comfort in partial-thickness burn wounds treated with SUPRATHEL and epictehydro wound dressings . Int Wound J . 2022 ; 19 ( 4 ): 782 – 790 . doi: 10.1111/iwj.13674 Open DOISearch in Google Scholar

[3] Stamenkovic DM, et al. Updates on wound infiltration use for postoperative pain management: a narrative review. J Clin Med. 2021;10(20):4659. doi: 10.3390/jcm10204659 Stamenkovic DM Updates on wound infiltration use for postoperative pain management: a narrative review . J Clin Med . 2021 ; 10 ( 20 ): 4659 . doi: 10.3390/jcm10204659 Open DOISearch in Google Scholar

[4] Small C, Laycock H. Acute postoperative pain management. Br J Surg. 2020;107(2). doi: 10.1002/bjs.11477 Small C Laycock H. Acute postoperative pain management . Br J Surg . 2020 ; 107 ( 2 ). doi: 10.1002/bjs.11477 Open DOISearch in Google Scholar

[5] Macintyre PE, Schug SA. Acute pain management: a practical guide. CRC Press; 2021. doi: 10.1201/9780429295058 Macintyre PE Schug SA. Acute pain management: a practical guide . CRC Press ; 2021 . doi: 10.1201/9780429295058 Open DOISearch in Google Scholar

[6] Kowalski G, et al. Analgesic efficacy of sufentanil in dressings after surgical treatment of burn wounds. Burns. 2021;47(4):880–887. doi: 10.1016/j.burns.2020.10.006 Kowalski G Analgesic efficacy of sufentanil in dressings after surgical treatment of burn wounds . Burns . 2021 ; 47 ( 4 ): 880 – 887 . doi: 10.1016/j.burns.2020.10.006 Open DOISearch in Google Scholar

[7] Wu Y, et al. Measures and effects of pain management for wound dressing change in outpatient children in Western China. J Pain Res. 2021:399–406. Wu Y Measures and effects of pain management for wound dressing change in outpatient children in Western China . J Pain Res . 2021 : 399 – 406 . Search in Google Scholar

[8] Froutan R, et al. The effect of inhalation aromatherapy on sedation level, analgesic dosage, and bispectral index values during donor site dressing in patients with burns: a randomized clinical trial. Adv Skin Wound Care. 2022;35(1):1–9. doi: 10.1097/01.ASW.0000801544.79621.24 Froutan R The effect of inhalation aromatherapy on sedation level, analgesic dosage, and bispectral index values during donor site dressing in patients with burns: a randomized clinical trial . Adv Skin Wound Care . 2022 ; 35 ( 1 ): 1 – 9 . doi: 10.1097/01.ASW.0000801544.79621.24 Open DOISearch in Google Scholar

[9] Ghomi ER, et al. Advances in electrospinning of aligned nanofiber scaffolds used for wound dressings. Curr Opin Biomed Eng. 2022;22:100393. doi: 10.1016/j.cobme.20 22.100393 Ghomi ER Advances in electrospinning of aligned nanofiber scaffolds used for wound dressings . Curr Opin Biomed Eng . 2022 ; 22 : 100393 . doi: 10.1016/j.cobme.20 22.100393 Open DOISearch in Google Scholar

[10] Liu Y, et al. Recent development of electrospun wound dressing. Curr Opin Biomed Eng. 2021;17:100247. doi: 10.1016/j.cobme.2020.100247 Liu Y Recent development of electrospun wound dressing . Curr Opin Biomed Eng . 2021 ; 17 : 100247 . doi: 10.1016/j.cobme.2020.100247 Open DOISearch in Google Scholar

[11] Bombin ADJ, Dunne NJ, McCarthy HO. Electrospinning of natural polymers for the production of nanofibres for wound healing applications. Mater Sci Eng C Mater Biol Appl. 2020;114:110994. doi: 10.1016/j.msec.2020.110994 Bombin ADJ Dunne NJ McCarthy HO. Electrospinning of natural polymers for the production of nanofibres for wound healing applications . Mater Sci Eng C Mater Biol Appl . 2020 ; 114 : 110994 . doi: 10.1016/j.msec.2020.110994 Open DOISearch in Google Scholar

[12] Gao C, et al. Electrospun nanofibers promote wound healing: theories, techniques, and perspectives. J Mater Chem B. 2021;9(14):3106–3130. doi: 10.1039/D1TB00 067E Gao C Electrospun nanofibers promote wound healing: theories, techniques, and perspectives . J Mater Chem B . 2021 ; 9 ( 14 ): 3106 – 3130 . doi: 10.1039/D1TB00 067E Open DOISearch in Google Scholar

[13] El Fawal G, et al. Fabrication of scaffold based on gelatin and polycaprolactone (PCL) for wound dressing application. J Drug Deliv Sci Technol. 2021;63:102501. doi: 10.1016/j.jddst.2021.102501 El Fawal G Fabrication of scaffold based on gelatin and polycaprolactone (PCL) for wound dressing application . J Drug Deliv Sci Technol . 2021 ; 63 : 102501 . doi: 10.1016/j.jddst.2021.102501 Open DOISearch in Google Scholar

[14] Afzal A, et al. Development and characterization of drug loaded PVA/PCL fibres for wound dressing applications. Polymers (Basel). 2023;15(6):1355. doi: 10.3390/poly m15061355 Afzal A Development and characterization of drug loaded PVA/PCL fibres for wound dressing applications . Polymers (Basel) . 2023 ; 15 ( 6 ): 1355 . doi: 10.3390/poly m15061355 Open DOISearch in Google Scholar

[15] Mouro C, Simões M, Gouveia IC. Emulsion electrospun fiber mats of PCL/PVA/chitosan and eugenol for wound dressing applications. Adv Polym Technol. 2019;2019:1–11. doi: 10.1155/2019/9859506 Mouro C Simões M Gouveia IC. Emulsion electrospun fiber mats of PCL/PVA/chitosan and eugenol for wound dressing applications . Adv Polym Technol . 2019 ; 2019 : 1 – 11 . doi: 10.1155/2019/9859506 Open DOISearch in Google Scholar

[16] Nedeljkovic SS, et al. Transversus abdominis plane block with liposomal bupivacaine for pain after cesarean delivery in a multicenter, randomized, double-blind, controlled trial. Anesth Analg. 2020;131(6):1830. doi: 10.1213/ANE.0000000000005075 Nedeljkovic SS Transversus abdominis plane block with liposomal bupivacaine for pain after cesarean delivery in a multicenter, randomized, double-blind, controlled trial . Anesth Analg . 2020 ; 131 ( 6 ): 1830 . doi: 10.1213/ANE.0000000000005075 Open DOISearch in Google Scholar

[17] Grindy SC, et al. Delivery of bupivacaine from UHMWPE and its implications for managing pain after joint arthroplasty. Acta Biomater. 2019;93:63–73. doi: 10.1016/j.actbio.2019.05.049 Grindy SC Delivery of bupivacaine from UHMWPE and its implications for managing pain after joint arthroplasty . Acta Biomater . 2019 ; 93 : 63 – 73 . doi: 10.1016/j.actbio.2019.05.049 Open DOISearch in Google Scholar

[18] Chahar P, Cummings KC III. Liposomal bupivacaine: a review of a new bupivacaine formulation. J Pain Res. 2012:257–264. doi: 10.2147/JPR.S27894 Chahar P Cummings KC III. Liposomal bupivacaine: a review of a new bupivacaine formulation . J Pain Res . 2012 : 257 – 264 . doi: 10.2147/JPR.S27894 Open DOISearch in Google Scholar

[19] Hakim RF. Effect of Carica papaya extract toward incised wound healing process in mice (Mus musculus) clinically and histologically. Evid Based Complement Alternat Med. 2019;2019. doi: 10.1155/2019/8306519 Hakim RF. Effect of Carica papaya extract toward incised wound healing process in mice (Mus musculus) clinically and histologically . Evid Based Complement Alternat Med . 2019 ; 2019 . doi: 10.1155/2019/8306519 Open DOISearch in Google Scholar

[20] Nafiu AB, et al. Papaya (Carica papaya L., pawpaw), in Nonvitamin and nonmineral nutritional supplements. Elsevier; 2019. p. 335–359. Nafiu AB Papaya (Carica papaya L., pawpaw), in Nonvitamin and nonmineral nutritional supplements . Elsevier ; 2019 . p. 335 – 359 . Search in Google Scholar

[21] Nayak BS, et al. Wound-healing potential of an ethanol extract of Carica papaya (Caricaceae) seeds. Int Wound J. 2012;9(6):650–655. doi: 10.1111/j.1742-481X.2011.00933.x Nayak BS Wound-healing potential of an ethanol extract of Carica papaya (Caricaceae) seeds . Int Wound J . 2012 ; 9 ( 6 ): 650 – 655 . doi: 10.1111/j.1742-481X.2011.00933.x Open DOISearch in Google Scholar

[22] Habibi S, et al. A bilayer mupirocin/bupivacaine-loaded wound dressing based on chitosan/poly (vinyl alcohol) nanofibrous mat: preparation, characterization, and controlled drug release. Int J Biol Macromol. 2023;240:124399. doi: 10.1016/j.ijbiomac.2023.124399 Habibi S A bilayer mupirocin/bupivacaine-loaded wound dressing based on chitosan/poly (vinyl alcohol) nanofibrous mat: preparation, characterization, and controlled drug release . Int J Biol Macromol . 2023 ; 240 : 124399 . doi: 10.1016/j.ijbiomac.2023.124399 Open DOISearch in Google Scholar

[23] Dubský M, et al. Pain management in older adults with chronic wounds. Drugs Aging. 2022;39(8):619–629. doi: 10.1007/s40266-022-00963-w Dubský M Pain management in older adults with chronic wounds . Drugs Aging . 2022 ; 39 ( 8 ): 619 – 629 . doi: 10.1007/s40266-022-00963-w Open DOISearch in Google Scholar

[24] John JV, et al. Electrospun nanofibers for wound management. ChemNanoMat. 2022;8(7). doi: 10.1002/cnma.202100349 John JV Electrospun nanofibers for wound management . ChemNanoMat . 2022 ; 8 ( 7 ). doi: 10.1002/cnma.202100349 Open DOISearch in Google Scholar

[25] Gul A, et al. Electrospun antibacterial nanomaterials for wound dressings applications. Membranes (Basel). 2021;11(12):908. doi: 10.3390/membranes11120908 Gul A Electrospun antibacterial nanomaterials for wound dressings applications . Membranes (Basel) . 2021 ; 11 ( 12 ): 908 . doi: 10.3390/membranes11120908 Open DOISearch in Google Scholar

[26] Hwang PA, et al. Electrospun nanofiber composite mat based on ulvan for wound dressing applications. Int J Biol Macromol. 2023;253:126646. doi: 10.1016/j.ijbiomac.2023.126646 Hwang PA Electrospun nanofiber composite mat based on ulvan for wound dressing applications . Int J Biol Macromol . 2023 ; 253 : 126646 . doi: 10.1016/j.ijbiomac.2023.126646 Open DOISearch in Google Scholar

[27] Alyas S, et al. Anti-inflammatory, antipyretic and analgesic activities of ethanol extract of Carica papaya. J Wildl Biodivers. 2020;4(3):18–23. DOI: doi: 10.22120/jwb.2020.120874.1116 Alyas S Anti-inflammatory, antipyretic and analgesic activities of ethanol extract of Carica papaya . J Wildl Biodivers . 2020 ; 4 ( 3 ): 18 – 23 . DOI: doi: 10.22120/jwb.2020.120874.1116 Open DOISearch in Google Scholar

[28] Pandey S, et al. Anti-inflammatory and immunomodulatory properties of Carica papaya. J Immunotoxicol. 2016;13(4):590–602. doi: 10.3109/1547691X.2016.1149528 Pandey S Anti-inflammatory and immunomodulatory properties of Carica papaya . J Immunotoxicol . 2016 ; 13 ( 4 ): 590 – 602 . doi: 10.3109/1547691X.2016.1149528 Open DOISearch in Google Scholar

[29] Ramesh K, Kambimath RS, Venkatesan N. Study of immunomodulatory activity of aqueous extract of Carica papaya in Wistar rats. Natl J Physiol Pharm Pharmacol. 2016;6(5):442. Ramesh K Kambimath RS Venkatesan N. Study of immunomodulatory activity of aqueous extract of Carica papaya in Wistar rats . Natl J Physiol Pharm Pharmacol . 2016 ; 6 ( 5 ): 442 . Search in Google Scholar

[30] Calori IR, et al. Polymer scaffolds as drug delivery systems. Eur Polym J. 2020;129:109621. doi: 10.1016/j.eurpolymj.2020.109621 Calori IR Polymer scaffolds as drug delivery systems . Eur Polym J . 2020 ; 129 : 109621 . doi: 10.1016/j.eurpolymj.2020.109621 Open DOISearch in Google Scholar

[31] Yang C, et al. Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy. Sci Bull (Beijing). 2020;65(17):1489–1504. doi: 10.1016/j.scib.2020.04.012 Yang C Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy . Sci Bull (Beijing) . 2020 ; 65 ( 17 ): 1489 – 1504 . doi: 10.1016/j.scib.2020.04.012 Open DOISearch in Google Scholar

[32] Gurung S, Škalko-Basnet N. Wound healing properties of Carica papaya latex: in vivo evaluation in mice burn model. J Ethnopharmacol. 2009;121(2):338–341. doi: 10.1016/j.jep.2008.10.030 Gurung S Škalko-Basnet N. Wound healing properties of Carica papaya latex: in vivo evaluation in mice burn model . J Ethnopharmacol . 2009 ; 121 ( 2 ): 338 – 341 . doi: 10.1016/j.jep.2008.10.030 Open DOISearch in Google Scholar

[33] Marlinawati IT, Santoso S, Irwanto Y. The effect of papaya leaf extract gel (Carica papaya) on interleukin-1β expression and collagen density (Col1A1) in the back incision wound healing of Wistar rats (Rattus norvegicus). Bahrain Med Bull. 2023;45(1). Marlinawati IT Santoso S Irwanto Y. The effect of papaya leaf extract gel (Carica papaya) on interleukin-1β expression and collagen density (Col1A1) in the back incision wound healing of Wistar rats (Rattus norvegicus) . Bahrain Med Bull . 2023 ; 45 ( 1 ). Search in Google Scholar

[34] Li X, et al. Antibacterial, antioxidant and biocompatible nanosized quercetin-PVA xerogel films for wound dressing. Colloids Surf B Biointerfaces. 2022;209:112175. doi: 10.1016/j.colsurfb.2021.112175 Li X Antibacterial, antioxidant and biocompatible nanosized quercetin-PVA xerogel films for wound dressing . Colloids Surf B Biointerfaces . 2022 ; 209 : 112175 . doi: 10.1016/j.colsurfb.2021.112175 Open DOISearch in Google Scholar

[35] Kong YR, et al. Beneficial role of Carica papaya extracts and phytochemicals on oxidative stress and related diseases: a mini review. Biol (Basel). 2021;10(4):287. doi: 10.3390/biology10040287 Kong YR Beneficial role of Carica papaya extracts and phytochemicals on oxidative stress and related diseases: a mini review . Biol (Basel) . 2021 ; 10 ( 4 ): 287 . doi: 10.3390/biology10040287 Open DOISearch in Google Scholar

[36] Sharma A, et al. Carica papaya L. leaves: deciphering its antioxidant bioactives, biological activities, innovative products, and safety aspects. Oxid Med Cell Longev. 2022;2022. Carica papaya L. leaves: deciphering its antioxidant bioactives, biological activities, innovative products, and safety aspects. Sharma A Carica papaya L. leaves: deciphering its antioxidant bioactives, biological activities, innovative products, and safety aspects . Oxid Med Cell Longev . 2022 ; 2022 . Carica papaya L. leaves: deciphering its antioxidant bioactives, biological activities, innovative products, and safety aspects. Search in Google Scholar

[37] Agada R, et al. Antioxidant and anti-diabetic activities of bioactive fractions of Carica papaya seeds extract. J King Saud Univ Sci. 2021;33(2):101342. doi: 10.1016/j.jksus.2021.101342 Agada R Antioxidant and anti-diabetic activities of bioactive fractions of Carica papaya seeds extract . J King Saud Univ Sci . 2021 ; 33 ( 2 ): 101342 . doi: 10.1016/j.jksus.2021.101342 Open DOISearch in Google Scholar

[38] Asghar N, et al. Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents. Chem Cent J. 2016;10:1–11. doi: 10.1186/s13065-016-0149-0 Asghar N Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents . Chem Cent J . 2016 ; 10 : 1 – 11 . doi: 10.1186/s13065-016-0149-0 Open DOISearch in Google Scholar

[39] Marlinawati IT, et al. Effect of papaya leaf extract gel (Carica papaya) on incision wound healing in Rattus norvegicus. Med Lab Technol J. 2022;8(2):102–111. doi: 10.31964/mltj.v0i0.455 Marlinawati IT Effect of papaya leaf extract gel (Carica papaya) on incision wound healing in Rattus norvegicus . Med Lab Technol J . 2022 ; 8 ( 2 ): 102 – 111 . doi: 10.31964/mltj.v0i0.455 Open DOISearch in Google Scholar

[40] Dwivedi MK, et al. Antioxidant, antibacterial activity, and phytochemical characterization of Carica papaya flowers. Beni-Suef Univ J Basic Appl Sci. 2020;9:1–11. doi: 10.1186/s43088-020-00048-w Dwivedi MK Antioxidant, antibacterial activity, and phytochemical characterization of Carica papaya flowers . Beni-Suef Univ J Basic Appl Sci . 2020 ; 9 : 1 – 11 . doi: 10.1186/s43088-020-00048-w Open DOISearch in Google Scholar

[41] Nafiu AB, Rahman MT. Selenium added unripe carica papaya pulp extracts enhance wound repair through TGF-β1 and VEGF-a signalling pathway. BMC Complement Altern Med. 2015;15(1):1–10. doi: 10.1186/s12906-015-0900-4 Nafiu AB Rahman MT. Selenium added unripe carica papaya pulp extracts enhance wound repair through TGF-β1 and VEGF-a signalling pathway . BMC Complement Altern Med . 2015 ; 15 ( 1 ): 1 – 10 . doi: 10.1186/s12906-015-0900-4 Open DOISearch in Google Scholar

[42] Deer TR, et al. Intrathecal bupivacaine for chronic pain: a review of current knowledge. Neuromodulation. 2002;5(4):196–207. doi: 10.1046/j.1525-1403.2002.02030.x Deer TR Intrathecal bupivacaine for chronic pain: a review of current knowledge . Neuromodulation . 2002 ; 5 ( 4 ): 196 – 207 . doi: 10.1046/j.1525-1403.2002.02030.x Open DOISearch in Google Scholar