1. bookVolume 38 (2020): Issue 3 (September 2020)
Journal Details
First Published
16 Apr 2011
Publication timeframe
4 times per year
access type Open Access

Preparation and characterization of pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate incorporating titanium dioxide

Published Online: 12 Dec 2020
Volume & Issue: Volume 38 (2020) - Issue 3 (September 2020)
Page range: 443 - 449
Received: 15 Oct 2018
Accepted: 23 Apr 2019
Journal Details
First Published
16 Apr 2011
Publication timeframe
4 times per year

The purpose of the present investigation was to prepare pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate (PEG-DA). Rutile titanium dioxide (TiO2) was employed to modify the PEG-DA hydrogels. The rutile titanium dioxide (TiO2) nanoparticles were prepared by direct oxidation of titanium in the presence of polyethylene glycol (PEG) at high temperature. The nanoparticles were characterized by FT-IR, XRD and SEM. The influence of experimental conditions, such as pH, type and amount of photoinitiators on the release profiles of donepezil hydrochloride (active pharmaceutical ingredient for Alzheimer disease) from modified PEG-DA hydrogels, was investigated. The drug release processes were analyzed kinetically using zero-order, first-order, Hixson-Crowell and Peppas models.


[1] Akinyemi A.J., Oboh G., Oyeleye S.I., Ogunsuyi O., Neurotox Res., 31 (2017), 560.10.1007/s12640-017-9701-5Search in Google Scholar

[2] Shori T.D., Meurling L., Pettersson T., Hugosson K., Hellstrom-Lindahl E., Andreasen N., Minthon L., Nordberg A., J. Neural Transm., 113 (2006), 1791.10.1007/s00702-006-0526-2Search in Google Scholar

[3] Easton A., Sankaranarayanan S., Tanghe A., Terwel D., Lin A.X., Hoque N., Bourin C., Gu H., Ahlijanian M., Bristow L., Psychopharmacology, 230 (2013), 279.10.1007/s00213-013-3152-3Search in Google Scholar

[4] Liew K.B., Tan Y.T.F., Peh K.K., AAPS Pharm- SciTech, 13 (2011), 1.10.1208/s12249-011-9729-4Search in Google Scholar

[5] Boinpally R., Chen L., Zukin S.R., McClure N., Hofbauer R.R.K., Periclou A., Clin. Drug Investig., 35 (2015), 427.10.1007/s40261-015-0296-4Search in Google Scholar

[6] Boeve B.F., Parkinsonism Relat. Disord., 18 (2012), 41.10.1016/S1353-8020(11)70015-3Search in Google Scholar

[7] Rafiee E., Rahpeyman, Turkish J. Chem., 40 (2016), 35.10.3906/kim-1502-67Search in Google Scholar

[8] Sedighi M., Rahimi F., Rezayan A.H., Shahbazi M.A., Witzigmann D., Huwyler J., J. Mater. Sci., 53 (2018), 14975.10.1007/s10853-018-2731-4Search in Google Scholar

[9] Pal A., Bajpai J., Baipai A.K., Polym. Bull., 75 (2018), 4691.10.1007/s00289-018-2291-4Search in Google Scholar

[10] Zhou J., Tang Q., Zhong J., Lei Z., Luo H., Tong Z., Jiang G., Liu X., J. Mater. Sci., 53 (2018), 14063.10.1007/s10853-018-2622-8Search in Google Scholar

[11] Akyol E., Senol S., Dogan O., Bulgarian Chem. Commun., 49 (2017), 57.Search in Google Scholar

[12] Senol S., Akyol E., J. Mater. Sci., 53 (2018), 14953.10.1007/s10853-018-2713-6Search in Google Scholar

[13] Huang Q.L., Xu H.-L., Li M.-T., Hou Z.-S., Lv C., Zhan X.-P., Li H.-L., Xia H., Wang H.Y., Sun H.-B., J. Lightwave Technol., 36 (2018), 3.10.1109/JLT.2017.2762696Search in Google Scholar

[14] Lv C., Xia H., Shi Q., Wang G., Wang Y.-S., Chen Q.-D., Zhang Y.-L., Liu L.-Q., Sun H.-B., Adv. Mater. Interf., 4 (2017), 1601002.10.1002/admi.201601002Search in Google Scholar

[15] Cacasan E.G., Sehnert R.M., Ehrhardt D.A., Grunlan M.A., Macromol. Mater. Eng., 302 (2017), 1600512.10.1002/mame.201600512Search in Google Scholar

[16] Smoak E.M., Henricus M.M., Banerjee I.A., J. Appl. Polym. Sci., 118 (2010), 2562.10.1002/app.32551Search in Google Scholar

[17] Ayhan H., Ayhan F., Turkish J. Biochem., 39 (2014), 403.10.5505/tjb.2014.94834Search in Google Scholar

[18] Tan G., Liao J., Ning C., Zhang L., J. Appl. Polym. Sci., 125 (2012), 3509.10.1002/app.36683Search in Google Scholar

[19] Ali S., Shehzad F.K., Maitlo I., Valiev S., Muhyodin G., Nie J., J. Appl. Polym. Sci., 118 (2018), 46686.10.1002/app.46686Search in Google Scholar

[20] Zhang C., Liang K., Zhou D., Yang H., Liu X., Yin X., Xu W., Zhou Y., Xiao P., ACS Appl. Mater. Interf., 10 (2018), 27692.10.1021/acsami.8b0902630048588Search in Google Scholar

[21] Sanai Y., Morita Y., Asano Y., Ishizaki K., Kubota K., J. Polym. Sci., 52 (2014), 1161.10.1002/pola.27100Search in Google Scholar

[22] Li Z., Chen H., Wang C., Chen L., Liu J., Liu R., J. Polym. Sci., 56 (2018), 994.10.1002/pola.28969Search in Google Scholar

[23] Han J., He Y., Xiao M., Ma G., Nie J., Polym. Adv. Technol., 20 (2009), 607.10.1002/pat.1299Search in Google Scholar

[24] Tao W., Fei F., Rong R., Yue-Chuan W., Polym. Int., 55 (2006), 883.10.1002/pi.2023Search in Google Scholar

[25] Djaoued Y., Robichaud J., Brüning R., Albert A.-S., Ashrit P.-V., Mater. Sci.-Poland, 23 (2005), 1.Search in Google Scholar

[26] Amir Oleyaei S., Razavi S.M. A., Mikkonen K.S., Int. J. Biol. Macromol., 118 (2018), 661.10.1016/j.ijbiomac.2018.06.04929924983Search in Google Scholar

[27] Wahid F., Zhong C., Wang H.-S., Hu X.-H., Chu L.-Q., Polymers, 9 (2017), 636.10.3390/polym9120636641880930965938Search in Google Scholar

[28] Petrović S., Rožić LJ., Vuković Z., Radić G.N., Stojadinović S., Vasilić R., J. Phys. Chem. Solids, 103 (2017), 95.10.1016/j.jpcs.2016.12.002Search in Google Scholar

[29] Nawaz M., Miran W., Jang J., Sung Lee D., Appl. Catal. B, 85 (2017), 203.10.1016/j.apcatb.2016.10.007Search in Google Scholar

[30] Hossain M.K., Pervez M.F., Mia M.N.H., Tayyaba S., Uddin M.J., Ahamed R., Khan R.A., Hoq M., Khan M.A., Ahmed F., Mater. Sci.-Poland, 35 (2017), 868.10.1515/msp-2017-0082Search in Google Scholar

[31] Mohamed S.G., Abdeltawab A.A., Shoeib M.A., Mater. Sci.-Poland, 30 (2012), 231.10.2478/s13536-012-0039-7Search in Google Scholar

[32] Ramos M.L.P., González J.A., Albornoz S.G., Pérez C.J., Villanueva M.E., Giorgieri S.A., Copello G.J., Chem. Eng. J., 285 (2016), 581.10.1016/j.cej.2015.10.035Search in Google Scholar

[33] Zhang H., Yang H., Shentu B., Chen S., Chen M., J. Appl. Polym. Sci., 135 (2018), 46099.10.1002/app.46099Search in Google Scholar

[34] Oliveira W.F., Arruda I.R.S., Silva G.M.M., Machado G., Coelho C.B.B., Correia M.T.S., Mater. Sci. Eng. C, 81 (2017), 597.10.1016/j.msec.2017.08.01728888015Search in Google Scholar

[35] Lin G., Tarasevich B., J. Appl. Polym. Sci., 128 (2013), 3534.10.1002/app.38560Search in Google Scholar

[36] Uddin M., Mondal D., Morris C.A., Lopez T., Diebold U., Gonzalez R.D., Appl. Surf. Sci., 257 (2011), 7920.10.1016/j.apsusc.2011.03.079Search in Google Scholar

[37] Lakka NS., Goswami N., Int. Res. J. Pharm., 3 (2012), 126.Search in Google Scholar

[38] Flory P.J., Principles of polymer chemistry, Cornell University, Ithaca, NY, 1953.Search in Google Scholar

[39] Drabczyk A., Kudłacik–Kramarczyk S., Tyliszczak B., Infrastruct. Ecol. Rural Areas, (2017), 1659.Search in Google Scholar

[40] Kazemi F., Arjmand R., Ahmedinejadi E., Kaboudin B., Iranian Polym. J., 27 (2018), 507.10.1007/s13726-018-0627-4Search in Google Scholar

[41] Ferreira P., Coelho J.F.J., Almeida J.F., Gil M.H., Biomed. Eng. Front. Chall., 3 (2011), 55.Search in Google Scholar

[42] Lin C.-C., Sawichi S.M., Metters A.T., Biomacromolecules, 9 (2008), 75.10.1021/bm700782c18088094Search in Google Scholar

[43] Dash S., Padala N.M., Nath L., Chowdhury P., Acta Poloniae Pharm. Drug Res., 67 (2010), 217.Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo