<abstract xmlns="http://www.w3.org/1999/xhtml">

This study aimed to determine the effects of oral application of <italic>Bifidobacterium animalis</italic> subsp. <italic>lactis</italic> and vitamin D on the immune response after vaccination in puppies. Crossbred dogs at the age of 55–65 days (n=21) of both sexes were grouped according to the application as follows: Group 1 - commercial polyvalent vaccine only (Vanguard 5L4, Zoetis); Group 2 -polyvalent vaccine and vitamin D; and Group 3 - polyvalent vaccine, <italic>B. animalis</italic> subsp. <italic>lactis</italic>, and vitamin D. The antibody titers, measured 3 weeks after the vaccination and after the 1st booster, demonstrated sufficient protective levels against the canine distemper virus but without significant difference between the groups when compare both values. No significant differences either, were observed in antibody titers against canine parvovirus after the initial vaccination. However, after the 1st booster, Group 2 samples showed significantly higher antibody titer value compared to the other groups (p&lt;0.05). In conclusion, the dogs included in this study had an adequate antibody response to canine parvovirus and distemper viruses following the vaccination and 1st booster in all three groups of animals, and significant increasing of protective antibody titers against canine parvovirus virus the after the 1st booster in the group where <italic>B. animalis</italic> subsp. <italic>lactis</italic> was included.
</abstract>

This study aimed to determine the effects of oral application of Bifidobacterium animalis subsp. lactis and vitamin D on the immune response after vaccination in puppies. Crossbred dogs at the age of 55–65 days (n=21) of both sexes were grouped according to the application as follows: Group 1 - commercial polyvalent vaccine only (Vanguard 5L4, Zoetis); Group 2 -polyvalent vaccine and vitamin D; and Group 3 - polyvalent vaccine, B. animalis subsp. lactis, and vitamin D. The antibody titers, measured 3 weeks after the vaccination and after the 1st booster, demonstrated sufficient protective levels against the canine distemper virus but without significant difference between the groups when compare both values. No significant differences either, were observed in antibody titers against canine parvovirus after the initial vaccination. However, after the 1st booster, Group 2 samples showed significantly higher antibody titer value compared to the other groups (p<0.05). In conclusion, the dogs included in this study had an adequate antibody response to canine parvovirus and distemper viruses following the vaccination and 1st booster in all three groups of animals, and significant increasing of protective antibody titers against canine parvovirus virus the after the 1st booster in the group where B. animalis subsp. lactis was included.

The Effects of <italic>Bifidobacterium animalis</italic> Subsp. <italic>Lactis</italic> and Vitamin D on Immunological Response Following Vaccination in Puppies

Department of Internal Medicine, Faculty of Veterinary Medicine

Macedonian Veterinary Review

This work is licensed under the Creative Commons Attribution 4.0 International License.

The Effects of  Subsp.  and Vitamin D on Immunological Response Following Vaccination in Puppies

This study aimed to determine the effects of oral application of Bifidobacterium animalis subsp. lactis and vitamin D on the immune response after vaccination...

The Effects of Bifidobacterium animalis Subsp. Lactis and Vitamin D on Immunological Response Following Vaccination in Puppies

Published Online: Sep 28, 2023

Page range: 199 - 206

Received: Mar 27, 2023

Accepted: Aug 09, 2023

DOI: https://doi.org/10.2478/macvetrev-2023-0025

Keywords
antibody response, subsp, canine parvovirus, vaccination, vitamin D

© 2023 Gökhan Saridag et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The Effects of Bifidobacterium animalis Subsp. Lactis and Vitamin D on Immunological Response Following Vaccination in Puppies

Published Online: Sep 28, 2023

Page range: 199 - 206

Received: Mar 27, 2023

Accepted: Aug 09, 2023

DOI: https://doi.org/10.2478/macvetrev-2023-0025

Keywordsantibody response, subsp, canine parvovirus, vaccination, vitamin D

© 2023 Gökhan Saridag et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
antibody response, subsp, canine parvovirus, vaccination, vitamin D