<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Myxomatous mitral valve disease (MMVD) is one of the most common heart diseases in dogs. The disease progresses faster in Cavalier King Charles Spaniel (CKCS) dogs and occurs at an earlier age. QT interval length reflects abnormalities in ventricular repolarization which may predispose to the formation of fatal arrhythmias such as torsades de pointes. A fast and accurate assessment is therefore essential. The study aimed to examine the changes in QT duration in MMVD cases of CKCS and to calculate the corrected QT durations with Bazett’s formula in various stages of the disease. The study included 20 CKCS dogs of both genders, various ages and weights, and different stages of MMVD (n=6 in B1 stage, n=6 in B2 stage, and n=8 in C stage), and 5 healthy CKCS which were included in the control group. Clinical, radiological, hematological, biochemical, echocardiographic, and electrocardiographic examinations were performed. The corrected QT interval duration in the MMVD group was longer than the control (p&lt;0.05). However, there was no significant difference between B1, B2, and C. It was concluded that the corrected QT interval can give a significant distinction between healthy and MMVD CKCS dogs.</p>
</abstract>

Myxomatous mitral valve disease (MMVD) is one of the most common heart diseases in dogs. The disease progresses faster in Cavalier King Charles Spaniel (CKCS) dogs and occurs at an earlier age. QT interval length reflects abnormalities in ventricular repolarization which may predispose to the formation of fatal arrhythmias such as torsades de pointes. A fast and accurate assessment is therefore essential. The study aimed to examine the changes in QT duration in MMVD cases of CKCS and to calculate the corrected QT durations with Bazett’s formula in various stages of the disease. The study included 20 CKCS dogs of both genders, various ages and weights, and different stages of MMVD (n=6 in B1 stage, n=6 in B2 stage, and n=8 in C stage), and 5 healthy CKCS which were included in the control group. Clinical, radiological, hematological, biochemical, echocardiographic, and electrocardiographic examinations were performed. The corrected QT interval duration in the MMVD group was longer than the control (p<0.05). However, there was no significant difference between B1, B2, and C. It was concluded that the corrected QT interval can give a significant distinction between healthy and MMVD CKCS dogs.

Evaluation of the Corrected QT Interval with Bazett’s Method in Cavalier King Charles Spaniel Dogs with Myxomatous Mitral Valve Disease

Department of Internal Medicine, Faculty of Veterinary Medicine

Macedonian Veterinary Review

This work is licensed under the Creative Commons Attribution 4.0 International License.

Myxomatous mitral valve disease (MMVD) is one of the most common heart diseases in dogs. The disease progresses faster in Cavalier King Charles Spaniel (CKCS)...

Evaluation of the Corrected QT Interval with Bazett’s Method in Cavalier King Charles Spaniel Dogs with Myxomatous Mitral Valve Disease

Published Online: Mar 02, 2023

Page range: 61 - 67

Received: Aug 29, 2022

Accepted: Feb 21, 2023

DOI: https://doi.org/10.2478/macvetrev-2023-0014

Keywords
Cavalier, myxomatous, mitral valve, QT

© 2023 Hande Sağoğlu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Evaluation of the Corrected QT Interval with Bazett’s Method in Cavalier King Charles Spaniel Dogs with Myxomatous Mitral Valve Disease

Published Online: Mar 02, 2023

Page range: 61 - 67

Received: Aug 29, 2022

Accepted: Feb 21, 2023

DOI: https://doi.org/10.2478/macvetrev-2023-0014

KeywordsCavalier, myxomatous, mitral valve, QT

© 2023 Hande Sağoğlu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
Cavalier, myxomatous, mitral valve, QT