<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The treatment of full-thickness skin burn using nanomaterials is promising as a medical application reducing the risk of infection and severe dermal scarring. Therefore, this study aims to evaluate the effectiveness of nanomaterials, particularly 3% silver nanoparticles containing ointment (3% SNO), on the full-thickness skin burn of laboratory mice. A total number of 36 male mice were used, equally divided into three groups: negative control (not burned and not treated); positive control (+ve) (burned and treated with castor oil and white petroleum jelly); and SNO-treated group (burned and treated with 3% SNO). The skin of the animals’ back was shaved. A 2x0.5 cm metal plate was heated on a burner to burn the skin of the animals of positive control and SNO-treated groups. <italic>Pseudomonas aeruginosa</italic> bacterial suspension was applied to the burnt area. The application of SNO, as well as the mixture of white petroleum jelly and castor oil, was started after 6 hours of inducing burns and continued for 14 days (three times daily) in the respected groups. The SNO-treated group showed accelerated healing within 14 days demonstrated by re-epithelialization of the epidermal layer and proliferation of the fibroblasts in the dermal layer. Less healing evidence was observed in the +ve control group in the same period. In conclusion, to our knowledge, this is the first study that uses a 3% SNO formula and has found that it has a promising impact on the treatment of infected skin burns.</p></abstract>

The treatment of full-thickness skin burn using nanomaterials is promising as a medical application reducing the risk of infection and severe dermal scarring. Therefore, this study aims to evaluate the effectiveness of nanomaterials, particularly 3% silver nanoparticles containing ointment (3% SNO), on the full-thickness skin burn of laboratory mice. A total number of 36 male mice were used, equally divided into three groups: negative control (not burned and not treated); positive control (+ve) (burned and treated with castor oil and white petroleum jelly); and SNO-treated group (burned and treated with 3% SNO). The skin of the animals’ back was shaved. A 2x0.5 cm metal plate was heated on a burner to burn the skin of the animals of positive control and SNO-treated groups. Pseudomonas aeruginosa bacterial suspension was applied to the burnt area. The application of SNO, as well as the mixture of white petroleum jelly and castor oil, was started after 6 hours of inducing burns and continued for 14 days (three times daily) in the respected groups. The SNO-treated group showed accelerated healing within 14 days demonstrated by re-epithelialization of the epidermal layer and proliferation of the fibroblasts in the dermal layer. Less healing evidence was observed in the +ve control group in the same period. In conclusion, to our knowledge, this is the first study that uses a 3% SNO formula and has found that it has a promising impact on the treatment of infected skin burns.

Effect of Silver Nanoparticles on Healing of Third-Degree Burns Infected with <italic>Pseudomonas Aeruginosa</italic> in Laboratory Mice

Department of Pharmacology and Toxicology

Macedonian Veterinary Review

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Effect of Silver Nanoparticles on Healing of Third-Degree Burns Infected with  in Laboratory Mice

The treatment of full-thickness skin burn using nanomaterials is promising as a medical application reducing the risk of infection and severe dermal scarring....

Effect of Silver Nanoparticles on Healing of Third-Degree Burns Infected with Pseudomonas Aeruginosa in Laboratory Mice

Published Online: Mar 15, 2021

Page range: 17 - 28

Received: Feb 16, 2020

Accepted: Nov 06, 2020

DOI: https://doi.org/10.2478/macvetrev-2020-0032

Keywords
silver nanoparticles, skin burns, silver ointment, skin healing, infected burns

© 2021 Mukhallad Abdul Kareem Ramadhan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Effect of Silver Nanoparticles on Healing of Third-Degree Burns Infected with Pseudomonas Aeruginosa in Laboratory Mice

Published Online: Mar 15, 2021

Page range: 17 - 28

Received: Feb 16, 2020

Accepted: Nov 06, 2020

DOI: https://doi.org/10.2478/macvetrev-2020-0032

Keywordssilver nanoparticles, skin burns, silver ointment, skin healing, infected burns

© 2021 Mukhallad Abdul Kareem Ramadhan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
silver nanoparticles, skin burns, silver ointment, skin healing, infected burns