<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A 15 year old female African lion (<bold><italic>Panthera leo</italic></bold>) was necropsied after its sudden death. The necropsy showed a mammary gland lesion measuring 10 cm in diameter and numerous white nodules with variable size in the liver, spleen, uterus, lungs and the heart. The histopathological examination showed that the neoplastic formation in the mammary region was a simple tubular carcinoma with metastases on the other organs. Upon immunohistochemical examination, the neoplastic cells expressed cytokeratins while the stroma of the tumour expressed vimentin. The proliferation index Ki-67 was moderate. Based on the macroscopic, histopathological and immunohistochemical findings, the neoplasia was diagnosed as a simple tubular mammary carcinoma.</p></abstract>

A 15 year old female African lion (Panthera leo) was necropsied after its sudden death. The necropsy showed a mammary gland lesion measuring 10 cm in diameter and numerous white nodules with variable size in the liver, spleen, uterus, lungs and the heart. The histopathological examination showed that the neoplastic formation in the mammary region was a simple tubular carcinoma with metastases on the other organs. Upon immunohistochemical examination, the neoplastic cells expressed cytokeratins while the stroma of the tumour expressed vimentin. The proliferation index Ki-67 was moderate. Based on the macroscopic, histopathological and immunohistochemical findings, the neoplasia was diagnosed as a simple tubular mammary carcinoma.

Mammary Adenocarcinoma with Widespread Metastasis in a Lion (<italic>Panthera Leo</italic>)

Institute of Pathology, Faculty of Medicine

Zoo Garden Skopje, Republic of North Macedonia

Macedonian Veterinary Review

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mammary Adenocarcinoma with Widespread Metastasis in a Lion ()

A 15 year old female African lion (Panthera leo) was necropsied after its sudden death. The necropsy showed a mammary gland lesion measuring 10 cm in diameter...

Mammary Adenocarcinoma with Widespread Metastasis in a Lion (Panthera Leo)

Published Online: Oct 15, 2019

Page range: 195 - 199

Received: Apr 17, 2019

Accepted: Jul 10, 2019

DOI: https://doi.org/10.2478/macvetrev-2019-0019

Keywords
carcinoma, mammary gland, lion

© 2019 Ivica Gjurovski et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mammary Adenocarcinoma with Widespread Metastasis in a Lion (Panthera Leo)

Published Online: Oct 15, 2019

Page range: 195 - 199

Received: Apr 17, 2019

Accepted: Jul 10, 2019

DOI: https://doi.org/10.2478/macvetrev-2019-0019

Keywordscarcinoma, mammary gland, lion

© 2019 Ivica Gjurovski et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
carcinoma, mammary gland, lion