Sub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in LublinLublin, Poland
Sub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in LublinLublin, Poland
Department of Animal Breeding and Agricultural Advisory, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in LublinLublin, Poland
Department of Animal Breeding and Agricultural Advisory, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in LublinLublin, Poland
Sub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in LublinLublin, Poland
Department of Animal Breeding and Agricultural Advisory, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in LublinLublin, Poland
This work is licensed under the Creative Commons Attribution 4.0 International License.
Aerts E.G., Harlow K., Griesgraber M.J., Bowdridge E.C., Hardy S.L.,Nestor C.C., Hileman S.M.: Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep. Biology 2021, 10, 988, doi: 10.3390/biology10100988.AertsE.G.HarlowK.GriesgraberM.J.BowdridgeE.C.HardyS.L.NestorC.C.HilemanS.M.: Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep. Biology2021, 10, 988, 10.3390/biology10100988.Open DOISearch in Google Scholar
Backholer K., Smith J.T., Rao A., Pereira A., Iqbal J., Ogawa S., Li Q., Clarke I.J.: Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology 2010, 151, 2233–2243, doi: 10.1210/en.2009-1190.BackholerK.SmithJ.T.RaoA.PereiraA.IqbalJ.OgawaS.LiQ.ClarkeI.J.: Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology2010, 151, 2233–2243, 10.1210/en.2009-1190.Open DOISearch in Google Scholar
Bedenbaugh M.N., Bowdridge E., Hileman S.M.: Role of neurokinin B in ovine puberty. Domest Anim Endocrinol 2020, 73, 106442, doi: 10.1016/j.domaniend.2020.106442.BedenbaughM.N.BowdridgeE.HilemanS.M.: Role of neurokinin B in ovine puberty. Domest Anim Endocrinol2020, 73, 106442, 10.1016/j.domaniend.2020.106442.Open DOISearch in Google Scholar
Billings H.J., Connors J.M., Altman S.N., Hileman S.M., Holaskova I., Lehman M.N., McManus C.J., Nestor C.C., Jacobs B.H., Goodman R.L.: Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep. Endocrinology 2010, 151, 3836–3846, doi: 10.1210/en.2010-0174.BillingsH.J.ConnorsJ.M.AltmanS.N.HilemanS.M.HolaskovaI.LehmanM.N.McManusC.J.NestorC.C.JacobsB.H.GoodmanR.L.: Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep. Endocrinology2010, 151, 3836–3846, 10.1210/en.2010-0174.Open DOISearch in Google Scholar
Dees W.L., Hiney J.K., Srivastava V.K.: Regulation of prepubertal dynorphin secretion in the medial basal hypothalamus of the female rat. J Neuroendocrinol 2019, 31, e12810, doi: 10.1111/jne.12810.DeesW.L.HineyJ.K.SrivastavaV.K.: Regulation of prepubertal dynorphin secretion in the medial basal hypothalamus of the female rat. J Neuroendocrinol2019, 31, e12810, 10.1111/jne.12810.Open DOISearch in Google Scholar
Goodman R.L., Moore A.M., Onslow K., Hileman S.M., Hardy S.L., Bowdridge E.C., Walters B.A., Agus S., Griesgraber M.J., Aerts E.G., Lehman M.N., Coolen L.M.: Lesions of KNDy and Kiss1R Neurons in the Arcuate Nucleus Produce Different Effects on LH Pulse Patterns in Female Sheep. Endocrinology 2023, 164, bqad148, doi: 10.1210/endocr/bqad148.GoodmanR.L.MooreA.M.OnslowK.HilemanS.M.HardyS.L.BowdridgeE.C.WaltersB.A.AgusS.GriesgraberM.J.AertsE.G.LehmanM.N.CoolenL.M.: Lesions of KNDy and Kiss1R Neurons in the Arcuate Nucleus Produce Different Effects on LH Pulse Patterns in Female Sheep. Endocrinology2023, 164, bqad148, 10.1210/endocr/bqad148.Open DOISearch in Google Scholar
Harlow K., Renwick A.N., Shuping S.L., Sommer J.R., Lents C.A., Knauer M.T., Nestor C.C.: Evidence that pubertal status impacts kisspeptin/neurokinin B/dynorphin neurons in the gilt. Biol Reprod 2021, 105, 1533–1544, doi: 10.1093/biolre/ioab189.HarlowK.RenwickA.N.ShupingS.L.SommerJ.R.LentsC.A.KnauerM.T.NestorC.C.: Evidence that pubertal status impacts kisspeptin/neurokinin B/dynorphin neurons in the gilt. Biol Reprod2021, 105, 1533–1544, 10.1093/biolre/ioab189.Open DOISearch in Google Scholar
Kosior-Korzecka U., Radwańska P., Witkowska K., Patkowski K., Wójcik M., Wessely-Szponder J., Bobowiec R.: Kisspeptin-10 and peptide 234 modulate GnRH-induced follicle-stimulating hormone secretion from anterior pituitary cells of prepubertal lambs in vitro. Med Weter 2014, 70, 599–603.Kosior-KorzeckaU.RadwańskaP.WitkowskaK.PatkowskiK.WójcikM.Wessely-SzponderJ.BobowiecR.: Kisspeptin-10 and peptide 234 modulate GnRH-induced follicle-stimulating hormone secretion from anterior pituitary cells of prepubertal lambs in vitro. Med Weter2014, 70, 599–603.Search in Google Scholar
Li Q., Millar R.P., Clarke I.J., Smith J.T.: Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep. Neuroendocrinology 2015, 101, 161–174, doi: 10.1159/000377702.LiQ.MillarR.P.ClarkeI.J.SmithJ.T.: Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep. Neuroendocrinology2015, 101, 161–174, 10.1159/000377702.Open DOISearch in Google Scholar
Mijiddorj T., Kanasaki H., Purwana I.N., Oride A., Sukhbaatar U.,Miyazaki K.: Role of Neurokinin B and Dynorphin A in pituitary gonadotroph and somatolactotroph cell lines. Endocrine J 2012, 59, 631–640, doi: 10.1507/endocrj.ej11-0401.MijiddorjT.KanasakiH.PurwanaI.N.OrideA.SukhbaatarU.MiyazakiK.: Role of Neurokinin B and Dynorphin A in pituitary gonadotroph and somatolactotroph cell lines. Endocrine J2012, 59, 631–640, 10.1507/endocrj.ej11-0401.Open DOISearch in Google Scholar
Mizrahi N., Gilon C., Atre I., Ogawa S., Parhar I.S., Levavi-Sivan B.: Deciphering Direct and Indirect Effects of Neurokinin B and GnRH in the Brain-Pituitary Axis of Tilapia. Front Endocrinol 2019, 10, 469, doi: 10.3389/fendo.2019.00469.MizrahiN.GilonC.AtreI.OgawaS.ParharI.S.Levavi-SivanB.: Deciphering Direct and Indirect Effects of Neurokinin B and GnRH in the Brain-Pituitary Axis of Tilapia. Front Endocrinol2019, 10, 469, 10.3389/fendo.2019.00469.Open DOISearch in Google Scholar
Mun S.H., Oh H.J., Kwon J.Y.: Response of Pituitary Cells and Tissues to Neurokinin B and F in the Nile tilapia. Dev Reprod 2022, 26, 13–21, doi: 10.12717/DR.2022.26.1.13.MunS.H.OhH.J.KwonJ.Y.: Response of Pituitary Cells and Tissues to Neurokinin B and F in the Nile tilapia. Dev Reprod2022, 26, 13–21, 10.12717/DR.2022.26.1.13.Open DOISearch in Google Scholar
Navarro V.M.: Interactions Between Kisspeptins and Neurokinin B. Adv Exp Med Biol 2013, 784, 325–347, doi: 10.1007/978-1-4614-6199-9_15.NavarroV.M.: Interactions Between Kisspeptins and Neurokinin B. Adv Exp Med Biol2013, 784, 325–347, 10.1007/978-1-4614-6199-9_15.Open DOISearch in Google Scholar
Navarro V.M., Castellano J.M., McConkey S.M., Pineda R., Ruiz-Pino F., Pinilla L., Clifton D.K., Tena-Sempere M., Steiner R.A.: Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab 2010, 300, E202–E210, doi: 10.1152/ajpendo.00517.2010.NavarroV.M.CastellanoJ.M.McConkeyS.M.PinedaR.Ruiz-PinoF.PinillaL.CliftonD.K.Tena-SempereM.SteinerR.A.: Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab2010, 300, E202–E210, 10.1152/ajpendo.00517.2010.Open DOISearch in Google Scholar
Navarro V.M., Gottsch M.L., Chavkin C., Okamura H., Clifton D.K., Steiner R.A.: Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci 2009, 29, 11859–11866, doi: 10.1523/JNEUROSCI.1569-09.2009.NavarroV.M.GottschM.L.ChavkinC.OkamuraH.CliftonD.K.SteinerR.A.: Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci2009, 29, 11859–11866, 10.1523/JNEUROSCI.1569-09.2009.Open DOISearch in Google Scholar
Nestor C.C., Briscoe A.M.S., Davis S.M., Valent M., Goodman R.L., Hileman S.M.: Evidence of a role for kisspeptin and neurokinin B in puberty of female sheep. Endocrinology 2012, 153, 2756–2765, doi: 10.1210/en.2011-2009.NestorC.C.BriscoeA.M.S.DavisS.M.ValentM.GoodmanR.L.HilemanS.M.: Evidence of a role for kisspeptin and neurokinin B in puberty of female sheep. Endocrinology2012, 153, 2756–2765, 10.1210/en.2011-2009.Open DOISearch in Google Scholar
Pinilla L., Aguilar E., Dieguez C., Millar R.P., Tena-Sempere M.: Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiol Rev 2012, 92, 1235–1316, doi: 10.1152/physrev.00037.2010.PinillaL.AguilarE.DieguezC.MillarR.P.Tena-SempereM.: Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiol Rev2012, 92, 1235–1316, 10.1152/physrev.00037.2010.Open DOISearch in Google Scholar
Radwańska P., Kosior-Korzecka U.: Effect of leptin on thyroidstimulating hormone secretion and nitric oxide release from pituitary cells of ewe lambs in vitro. J Physiol Pharmacol 2014, 65, 145–151.RadwańskaP.Kosior-KorzeckaU.: Effect of leptin on thyroidstimulating hormone secretion and nitric oxide release from pituitary cells of ewe lambs in vitro. J Physiol Pharmacol2014, 65, 145–151.Search in Google Scholar
Radwańska P., Kosior-Korzecka U.: Relationships between leptin, KiSS-1/GPR54 expression and TSH secretion from pituitary cells of pubertal ewes in vitro. Res Vet Sci 2016, 105, 180–187, doi: 10.1016/j.rvsc.2016.02.014.RadwańskaP.Kosior-KorzeckaU.: Relationships between leptin, KiSS-1/GPR54 expression and TSH secretion from pituitary cells of pubertal ewes in vitro. Res Vet Sci2016, 105, 180–187, 10.1016/j.rvsc.2016.02.014.Open DOISearch in Google Scholar
Radwańska P., Kosior-Korzecka U.: Relationships between leptin, the KiSS-1/GPR54 system and thyrotropic axis activity in ewe lambs predisposed to the delayed puberty. Small Rumin Res 2016, 144, 6–16, doi: 10.1016/j.smallrumres.2016.07.019.RadwańskaP.Kosior-KorzeckaU.: Relationships between leptin, the KiSS-1/GPR54 system and thyrotropic axis activity in ewe lambs predisposed to the delayed puberty. Small Rumin Res2016, 144, 6–16, 10.1016/j.smallrumres.2016.07.019.Open DOISearch in Google Scholar
Rance N.E., Krajewski S.J., Smith M.A., Cholanian M., Dacks P.A.: Neurokinin B and the hypothalamic regulation of reproduction. Brain Res 2010, 1364, 116–128, doi: 10.1016/j.brainres.2010.08.059.RanceN.E.KrajewskiS.J.SmithM.A.CholanianM.DacksP.A.: Neurokinin B and the hypothalamic regulation of reproduction. Brain Res2010, 1364, 116–128, 10.1016/j.brainres.2010.08.059.Open DOISearch in Google Scholar
Richard N., Corvaisier S., Camacho E., Kottler M.L.: KiSS-1 and GPR54 at the pituitary level: Overview and recent insights. Peptides 2009, 30, 123–129, doi: 10.1016/j.peptides.2008.09.015.RichardN.CorvaisierS.CamachoE.KottlerM.L.: KiSS-1 and GPR54 at the pituitary level: Overview and recent insights. Peptides2009, 30, 123–129, 10.1016/j.peptides.2008.09.015.Open DOISearch in Google Scholar
Suzuki S., Kadokawa H., Hashizume T.: Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells. Anim Reprod Sci 2008, 103, 360–365, doi: 10.1016/j.anireprosci.2007.05.016.SuzukiS.KadokawaH.HashizumeT.: Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells. Anim Reprod Sci2008, 103, 360–365, 10.1016/j.anireprosci.2007.05.016.Open DOISearch in Google Scholar
Szysiak N., Kosior-Korzecka U., Longo V., Cavallero A., Szymczak B., Furmańczyk-Gnyp A., Nguyen Ngoc D., Nowakiewicz A., Puzio I., Surówka B., Minakow N.: Effect of saturated fatty acid on GnRH-induced gonadotropin secretion from anterior pituitary cells of pubescent ewe lambs. Med Weter 2023, 79, 633–636, doi: 10.21521/mw.6837.SzysiakN.Kosior-KorzeckaU.LongoV.CavalleroA.SzymczakB.Furmańczyk-GnypA.Nguyen NgocD.NowakiewiczA.PuzioI.SurówkaB.MinakowN.: Effect of saturated fatty acid on GnRH-induced gonadotropin secretion from anterior pituitary cells of pubescent ewe lambs. Med Weter2023, 79, 633–636, 10.21521/mw.6837.Open DOISearch in Google Scholar
Szysiak N., Kosior-Korzecka U., Longo V., Patkowski K., Greguła-Kania M., Nowakiewicz A., Bochniarz M., Junkuszew A.: Influence of neurokinin B, dynorphin A and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes. J Vet Res 2025, 69, 121–129, doi: 10.2478/jvetres-2025-0003.SzysiakN.Kosior-KorzeckaU.LongoV.PatkowskiK.Greguła-KaniaM.NowakiewiczA.BochniarzM.JunkuszewA.: Influence of neurokinin B, dynorphin A and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes. J Vet Res2025, 69, 121–129, 10.2478/jvetres-2025-0003.Open DOISearch in Google Scholar
Terasawa E., James G.P., Seminara S.B., Keen K.L.: Role of kisspeptin and neurokinin B in puberty in female non-human primates. Front Endocrinol 2018, 9, 148, doi: 10.3389/fendo.2018.00148.TerasawaE.JamesG.P.SeminaraS.B.KeenK.L.: Role of kisspeptin and neurokinin B in puberty in female non-human primates. Front Endocrinol2018, 9, 148, 10.3389/fendo.2018.00148.Open DOISearch in Google Scholar
Topaloğlu K., Reimann F., Guclu M., Yalin A.S., Kotan L.D., Porter K.M., Serin A., Mungan N.O., Cook J.R., Imamoğlu S., Akalin N.S., Yuksel B., O’Rahilly S., Semple R.K.: TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. Nat Genet 2009, 41, 354–358, doi: 10.1038/ng.306.TopaloğluK.ReimannF.GucluM.YalinA.S.KotanL.D.PorterK.M.SerinA.MunganN.O.CookJ.R.ImamoğluS.AkalinN.S.YukselB.O’RahillyS.SempleR.K.: TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. Nat Genet2009, 41, 354–358, 10.1038/ng.306.Open DOISearch in Google Scholar
Van Vugt D.A., Meites J.: Influence of endogenous opiates on anterior pituitary function. Fed Proc 1980, 39, 2533–2538.Van VugtD.A.MeitesJ.: Influence of endogenous opiates on anterior pituitary function. Fed Proc1980, 39, 2533–2538.Search in Google Scholar
Wakabayashi Y., Nakada T., Murata K., Ohkura S., Mogi K., Navarro V.M., Clifton D.K., Mori Y., Tsukamura H., Maeda K.I., Steiner R.A., Okamura H.: Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat. J Neurosci 2010, 30, 3124–3132, doi: 10.1523/JNEUROSCI.5848-09.2010.WakabayashiY.NakadaT.MurataK.OhkuraS.MogiK.NavarroV.M.CliftonD.K.MoriY.TsukamuraH.MaedaK.I.SteinerR.A.OkamuraH.: Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat. J Neurosci2010, 30, 3124–3132, 10.1523/JNEUROSCI.5848-09.2010.Open DOISearch in Google Scholar
Young J., Bouligand J., Francou B., Raffin-Sanson M.L., Gaillez S., Jeanpierre M., Grynberg M., Kamenicky P., Chanson P., Brailly-Tabard S., Guiochon-Mantel A.: TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans. J Clin Endocrinol Metab 2010, 95, 2287–2295, doi: 10.1210/jc.2009-2600.YoungJ.BouligandJ.FrancouB.Raffin-SansonM.L.GaillezS.JeanpierreM.GrynbergM.KamenickyP.ChansonP.Brailly-TabardS.Guiochon-MantelA.: TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans. J Clin Endocrinol Metab2010, 95, 2287–2295, 10.1210/jc.2009-2600.Open DOISearch in Google Scholar
Żmijewska A., Czelejewska W., Drzewiecka E.M., Franczak A.: Effect of kisspeptin (KISS) and RFamide-related peptide-3 (RFRP-3) on the synthesis and secretion of FSH in vitro by pituitary cells in pigs. Theriogenology 2021, 171, 72–84, doi: 10.1016/j.theriogenology.2021.05.010.ŻmijewskaA.CzelejewskaW.DrzewieckaE.M.FranczakA.: Effect of kisspeptin (KISS) and RFamide-related peptide-3 (RFRP-3) on the synthesis and secretion of FSH in vitro by pituitary cells in pigs. Theriogenology2021, 171, 72–84, 10.1016/j.theriogenology.2021.05.010.Open DOISearch in Google Scholar