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Effect of Curcuma longa maceration treatment on ovarian follicular development, serum oestradiol, uterine growth and vascularisation in female albino rats

Andriyanto Andriyanto

Andriyanto Andriyanto

Division of Pharmacology and ToxicologyWest Java, Indonesia
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Andriyanto, Andriyanto
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Hamdika Yendri Putra

Hamdika Yendri Putra

eLRosa Laboratory, iRATco Group, Dramaga BogorWest Java, Indonesia
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Putra, Hamdika Yendri
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Mawar Subangkit

Mawar Subangkit

Division of PathologyWest Java, Indonesia
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Subangkit, Mawar
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Elpita Tarigan

Elpita Tarigan

eLRosa Laboratory, iRATco Group, Dramaga BogorWest Java, Indonesia
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Tarigan, Elpita
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Leliana Nugrahaning Widi

Leliana Nugrahaning Widi

Division of Pharmacology and ToxicologyWest Java, Indonesia
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Nugrahaning Widi, Leliana
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Yusa Irarang

Yusa Irarang

eLRosa Laboratory, iRATco Group, Dramaga BogorWest Java, Indonesia
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Irarang, Yusa
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Wasmen Manalu

Wasmen Manalu

Division of Physiology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Kampus IPB Dramaga BogorWest Java, Indonesia
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Manalu, Wasmen
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Amaq Fadholly

Amaq Fadholly

Division of Pharmacology and ToxicologyWest Java, Indonesia
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Fadholly, Amaq
  
Apr 04, 2024
Effect of Curcuma longa maceration treatment on ovarian follicular development, serum oestradiol, uterine growth and vascularisation in female albino rats's Cover Image
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Published Online: Apr 04, 2024
Page range: 287 - 294
Received: Oct 03, 2023
Accepted: Mar 25, 2024
DOI: https://doi.org/10.2478/jvetres-2024-0020
Keywords
© 2024 Andriyanto Andriyanto et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1.

The uterine (A) and ovary (B) relative weight of experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; * – significant difference compared to the control group (P-value < 0.05); ns – non significant
The uterine (A) and ovary (B) relative weight of experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; * – significant difference compared to the control group (P-value < 0.05); ns – non significant

Fig. 2.

Diameter (A), length (B), and vascularisation (C) of uterus in experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; NS/ns – non significant
Diameter (A), length (B), and vascularisation (C) of uterus in experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; NS/ns – non significant

Fig. 3.

Gross pathology of the uterus and its vascularisation in experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)
Gross pathology of the uterus and its vascularisation in experimental Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)

Fig. 4.

Histopathological visualisation showing the effect of 20 days’ Curcuma longa maceration administration on the uterine gland of experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)
Histopathological visualisation showing the effect of 20 days’ Curcuma longa maceration administration on the uterine gland of experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)

Fig. 5.

Histopathological visualisation showing the effect of 20 days’ Curcuma longa maceration administration on the follicles of experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)
Histopathological visualisation showing the effect of 20 days’ Curcuma longa maceration administration on the follicles of experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)

Fig. 6.

Immunohistochemical staining showing the effect of 20 days’ Curcuma longa maceration administration on the expression of ovarian vascular endothelial growth factor by experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)
Immunohistochemical staining showing the effect of 20 days’ Curcuma longa maceration administration on the expression of ovarian vascular endothelial growth factor by experimental Sprague Dawley rats. The maceration was administered at doses of 0% (A – Control), 1% (B – Cur-Low) or 5% (C – Cur-High)

Fig. 7.

Serum follicle-stimulating hormone (FSH) (A), oestradiol (B) and progesterone (C) concentrations in experimental female Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; * – significant difference compared to the control group (P-value < 0.05); ns – non significant
Serum follicle-stimulating hormone (FSH) (A), oestradiol (B) and progesterone (C) concentrations in experimental female Sprague Dawley rats after 20 days’ treatment with Curcuma longa maceration at doses of 0% (Control), 1% (Cur-Low) or 5% (Cur-High). ANOVA – one-way analysis of variance; * – significant difference compared to the control group (P-value < 0.05); ns – non significant
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