This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Fig. 1.
Example recording of a rat distal colon strip’s reactivity to acetylcholine (ACh) in the presence of modified Krebs–Henseleit solution (control reaction) and cannabidiol (CBD). F – flushing
Fig. 2.
Example recording of a rat distal colon strip’s reactivity to acetylcholine (Ach) in the presence of modified Krebs–Hanseleit solution (control reaction), diclofenac (DCF) and DCF with cannabidiol (CBD). F – flushing
Fig. 3.
Example recording of a rat distal colon strip’s reactivity to acetylcholine (Ach) in the presence of modified Krebs–Hanseleit solution (control reaction), dexamethasone (DEX) and DEX with cannabidiol (CBD). F – flushing
Fig. 4.
Comparison of the effects of tested substances on rat colon contractility relative to control acetylcholine administration; (a) Cannabidiol (CBD), diclofenac (DCF) and dexamethasone (DEX) administered alone; (b) CBD, DCF and DEX administered in combinations. Data are expressed as the mean of independent experiments; n = 5, ± standard deviation. Asterisks indicate a statistically significant difference at the level of P ≤ 0.05 (*), P<0.01 (**), P ≤ 0.001 (***) or P ≤ 0.0001 (****)