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Diclofenac and dexamethasone modulate the effect of cannabidiol on the rat colon motility ex vivo

Magdalena Chłopecka

Magdalena Chłopecka

Division of Pharmacology and Toxicology, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWWarsaw, Poland
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Chłopecka, Magdalena
, 
Łukasz Kiraga

Łukasz Kiraga

Division of Pharmacology and Toxicology, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWWarsaw, Poland
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Kiraga, Łukasz
, 
Kijan Crowley

Kijan Crowley

Division of Pharmacology and Toxicology, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWWarsaw, Poland
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Crowley, Kijan
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Michał Jank

Michał Jank

Division of Pharmacology and Toxicology, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWWarsaw, Poland
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Jank, Michał
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Urszula Latek

Urszula Latek

Division of Pharmacology and Toxicology, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWWarsaw, Poland
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Latek, Urszula
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Marta Mendel

Marta Mendel

Division of Pharmacology and Toxicology, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWWarsaw, Poland
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Mendel, Marta
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Wojciech Karlik

Wojciech Karlik

Division of Pharmacology and Toxicology, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWWarsaw, Poland
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Karlik, Wojciech
  
Jun 16, 2023
Diclofenac and dexamethasone modulate the effect of cannabidiol on the rat colon motility ex vivo's Cover Image
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Published Online: Jun 16, 2023
Page range: 289 - 295
Received: Dec 14, 2022
Accepted: May 12, 2023
DOI: https://doi.org/10.2478/jvetres-2023-0029
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© 2023 Magdalena Chłopecka et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1.

Example recording of a rat distal colon strip’s reactivity to acetylcholine (ACh) in the presence of modified Krebs–Henseleit solution (control reaction) and cannabidiol (CBD). F – flushing
Example recording of a rat distal colon strip’s reactivity to acetylcholine (ACh) in the presence of modified Krebs–Henseleit solution (control reaction) and cannabidiol (CBD). F – flushing

Fig. 2.

Example recording of a rat distal colon strip’s reactivity to acetylcholine (Ach) in the presence of modified Krebs–Hanseleit solution (control reaction), diclofenac (DCF) and DCF with cannabidiol (CBD). F – flushing
Example recording of a rat distal colon strip’s reactivity to acetylcholine (Ach) in the presence of modified Krebs–Hanseleit solution (control reaction), diclofenac (DCF) and DCF with cannabidiol (CBD). F – flushing

Fig. 3.

Example recording of a rat distal colon strip’s reactivity to acetylcholine (Ach) in the presence of modified Krebs–Hanseleit solution (control reaction), dexamethasone (DEX) and DEX with cannabidiol (CBD). F – flushing
Example recording of a rat distal colon strip’s reactivity to acetylcholine (Ach) in the presence of modified Krebs–Hanseleit solution (control reaction), dexamethasone (DEX) and DEX with cannabidiol (CBD). F – flushing

Fig. 4.

Comparison of the effects of tested substances on rat colon contractility relative to control acetylcholine administration; (a) Cannabidiol (CBD), diclofenac (DCF) and dexamethasone (DEX) administered alone; (b) CBD, DCF and DEX administered in combinations. Data are expressed as the mean of independent experiments; n = 5, ± standard deviation. Asterisks indicate a statistically significant difference at the level of P ≤ 0.05 (*), P<0.01 (**), P ≤ 0.001 (***) or P ≤ 0.0001 (****)
Comparison of the effects of tested substances on rat colon contractility relative to control acetylcholine administration; (a) Cannabidiol (CBD), diclofenac (DCF) and dexamethasone (DEX) administered alone; (b) CBD, DCF and DEX administered in combinations. Data are expressed as the mean of independent experiments; n = 5, ± standard deviation. Asterisks indicate a statistically significant difference at the level of P ≤ 0.05 (*), P<0.01 (**), P ≤ 0.001 (***) or P ≤ 0.0001 (****)
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English
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Life Sciences, Molecular Biology, Microbiology and Virology, Life Sciences, other, Medicine, Veterinary Medicine
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