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Determination of veterinary drug residues, mycotoxins, and pesticide residues in bovine milk by liquid chromatography electrospray ionisation –tandem mass spectrometry

Zehra Hajrulai-Musliu
Zehra Hajrulai-Musliu
, 
Risto Uzunov
Risto Uzunov
, 
Stefan Jovanov
Stefan Jovanov
, 
Maksud Kerluku
Maksud Kerluku
, 
Dean Jankuloski
Dean Jankuloski
, 
Velimir Stojkovski
Velimir Stojkovski
, 
Lazo Pendovski
Lazo Pendovski
 and 
James Jacob Sasanya
James Jacob Sasanya
   | May 31, 2022
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Published Online: May 31, 2022
Page range: 215 - 224
Received: Jan 10, 2022
Accepted: May 17, 2022
DOI: https://doi.org/10.2478/jvetres-2022-0027
Keywords
© 2022 Z. Hajrulai-Musliu et al. published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1a

The chromatograms of spiked milk samples at concentration level 2 from Supplementary Table 5 TEST – testosterone; MEST – methyltestosterone; BOLD – boldenone; 19NO – 19-nortestosterone; STZL – stanozolol; CLBL – clostebol; ZENL – zeranol; TANL – taleranol; CLEN – clenbuterol; BROM – brombuterol; MABT – mabuterol; CLEP – clenpenterol; ISOX – isoxsuprine; CIMB – cimbuterol; RACT – ractopamine; SALB – salbutamol; ZILP – zilpaterol; TERB – terbutaline hemisulphate; AMOX – amoxicillin; AMP – ampicillin; BNPC – benzylpenicillin
The chromatograms of spiked milk samples at concentration level 2 from Supplementary Table 5 TEST – testosterone; MEST – methyltestosterone; BOLD – boldenone; 19NO – 19-nortestosterone; STZL – stanozolol; CLBL – clostebol; ZENL – zeranol; TANL – taleranol; CLEN – clenbuterol; BROM – brombuterol; MABT – mabuterol; CLEP – clenpenterol; ISOX – isoxsuprine; CIMB – cimbuterol; RACT – ractopamine; SALB – salbutamol; ZILP – zilpaterol; TERB – terbutaline hemisulphate; AMOX – amoxicillin; AMP – ampicillin; BNPC – benzylpenicillin

Fig. 1b

The chromatograms of spiked milk samples at concentration level 2 from Supplementary Table 5 LINK – lincomycin; TYLS – tylosine; TRIP – trimethoprim; CEPR – cefapirin; TETC – tetracycline; CLCN – cloxacillin; OXIN – oxacillin; CEFA – cefalexin; CEFT – ceftiofur; ENRO – enrofloxacin; CIPR – ciprofloxacin; OXTT – oxytetracycline; SUPZ – sulfachloropyridazine; SUDI – sulfadiazine; SUDM – sulfadimethoxine; SULD – sulfadimidine; SULM – sulfamethoxazole; CRL – carbaryl; CRB – carbofuran; PTN – parathion; MTN – malathion
The chromatograms of spiked milk samples at concentration level 2 from Supplementary Table 5 LINK – lincomycin; TYLS – tylosine; TRIP – trimethoprim; CEPR – cefapirin; TETC – tetracycline; CLCN – cloxacillin; OXIN – oxacillin; CEFA – cefalexin; CEFT – ceftiofur; ENRO – enrofloxacin; CIPR – ciprofloxacin; OXTT – oxytetracycline; SUPZ – sulfachloropyridazine; SUDI – sulfadiazine; SUDM – sulfadimethoxine; SULD – sulfadimidine; SULM – sulfamethoxazole; CRL – carbaryl; CRB – carbofuran; PTN – parathion; MTN – malathion

Fig. 1c

The chromatograms of spiked milk samples at concentration level 2 from Supplementary Table 5 DNN – diazinon; DIM – dimethoate; ATRZ – atrazine; PEMT – permethrin; CIRM – cypermethrin; DELM – deltamethrin; COU – coumaphos; DIRP – dichlorvos; CHRS – chlorpyrifos; FERT – fenvalerate; BOS – boscalid; FETE – phenthoate; FEON – fenthion; MOCR – monocrotophos; MAON – malaoxon; MEDF – methamidophos; MECF – methacrifos; AMRZ – amitraz; OMAT – omethoate; VAON – vamidothion; FOST – phosmet
The chromatograms of spiked milk samples at concentration level 2 from Supplementary Table 5 DNN – diazinon; DIM – dimethoate; ATRZ – atrazine; PEMT – permethrin; CIRM – cypermethrin; DELM – deltamethrin; COU – coumaphos; DIRP – dichlorvos; CHRS – chlorpyrifos; FERT – fenvalerate; BOS – boscalid; FETE – phenthoate; FEON – fenthion; MOCR – monocrotophos; MAON – malaoxon; MEDF – methamidophos; MECF – methacrifos; AMRZ – amitraz; OMAT – omethoate; VAON – vamidothion; FOST – phosmet

Fig. 1d

The chromatograms of spiked milk samples at concentration level 2 from Supplementary Table 5 HEPH – heptenophos; BFNT – bifenthrin; MEML – methomyl; ZEAN – zearalenone; OTAA – ochratoxin; ATM – aflatoxin
The chromatograms of spiked milk samples at concentration level 2 from Supplementary Table 5 HEPH – heptenophos; BFNT – bifenthrin; MEML – methomyl; ZEAN – zearalenone; OTAA – ochratoxin; ATM – aflatoxin

The mobile phases studied

No. Mobile phase A Mobile phase B
1 Water with 5 mM ammonium acetate and 0.1% formic acid Acetonitrile with 0.1% formic acid
2 Water with 5 mM ammonium acetate and 0.1% formic acid Acetonitrile : methanol (50/50; v/v) with 0.1% formic acid
3 Water with 5 mM ammonium acetate and 0.1% formic acid Methanol with 0.1% formic acid
4 Water with 5 mM ammonium acetate and 0.01% formic acid Methanol with 0.1% formic acid
5 Water with 5 mM ammonium acetate, 0.1% formic acid and 0.01% trichloroacetic acid (TCA) Methanol with 0.1% formic acid
6 Water with 5 mM ammonium acetate, 0.01% formic acid and 0.01% TCA Methanol with 0.1% formic acid
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Language:
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Life Sciences, Molecular Biology, Microbiology and Virology, other, Medicine, Veterinary Medicine
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