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Antibiotic susceptibility of mycobacteria isolated from ornamental fish

Leszek Guz
Leszek Guz
 and 
Krzysztof Puk
Krzysztof Puk
   | Mar 25, 2022
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Published Online: Mar 25, 2022
Page range: 69 - 76
Received: Sep 03, 2021
Accepted: Mar 01, 2022
DOI: https://doi.org/10.2478/jvetres-2022-0011
Keywords
© 2022 L. Guz, K. Puk., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antimicrobial resistance or susceptibility determined by microdilution

NTM species (number of isolates tested) Resistant (R) or susceptible (S) Percentage of strains resistant or susceptible for each antimicrobial agent
Amikacin Kanamycin Tobramycin Doxycycline Clarithromycin Ciprofloxacin Sulfamethoxazole Rifampicin Isoniazid
M. abscessus (n = 1) R 100.00 100.00 100.00 100.00 100.00
I 100.00
S 100.00 100.00 100.00
M. chelonae (n = 16) R 6.25 43.75 100.00 6.25 100.00 100.00 100.00 100.00
I 12.50 12.50 50.00
S 81.25 87.50 6.25 93.75
M. fortuitum (n = 10) R 10.00 100.00 90.00 50.00 10.00 10.00 100.00 100.00
I 10.00 40.00
S 90.00 90.00 10.00 10.00 90.00 90.00
M. (n gordonae = 15) R 20.00 6.67 20.00 93.33 100.00
I 46.67
S 100.00 100.00 33.33 100.00 93.33 80.00 100.00 6.67
M. marinum (n = 33) R 3.03 9.09 12.12 93.94 100.00
I 87.88 3.03
S 100.00 100.00 9.09 90.91 96.97 87.88 100.00 6.06
M. (n mucogenicum = 1) R 100.00 100.00 100.00 100.00 100.00
I 100.00
S 100.00 100.00 100.00
M. neoaurum (n = 2) R 100.00 100.00
I
S 100.00 100.00 100.00 100.00 100.00 100.00 100.00
M. peregrinum (n = 12) R 8.33 8.33 8.33 66.67 8.33 8.33 100.00 100.00
I 33.33 8.33 8.33
S 91.67 91.67 58.33 25.00 83.34 91.67 100.00
M. salmoniphilum (n = 1) R 100.00 100.00 100.00
I
S 100.00 100.00 100.00 100.00 100.00 100.00
M. saopaulense (n = 1) R 100.00 100.00 100.00 100.00
I 100.00 100.00
S 100.00 100.00 100.00
M. senegalense (n = 4) R 25.00 25.00 75.00 25.00 100.00 100.00
I 25.00 25.00
S 100.00 100.00 75.00 75.00 75.00 75.00
M. septicum (n = 2) R 50.00 100.00 100.00
I 50.00 50.00
S 100.00 100.00 100.00 100.00 50.00 100.00
M. szulgai (n = 1) R 100.00 100.00 100.00
I
S 100.00 100.00 100.00 100.00 100.00 100.00

Antibiotic susceptibility profiles of RGM and SGM isolated from diseased fish

Antimicrobial agent Susceptibility
RGM (n = 50)
 SGM (n = 49)
S I R S I R
AMK 90.00 4.00 6.00 100 0.00 0.00
KAN 92.00 6.00 2.00 100 0.00 0.00
TOB 32.00 28.00 40.00 16.33 73.47 10.20
DOX 18.00 4.00 78.00 93.88 0.00 6.12
CLR 72.00 12.00 16.00 95.92 2.04 2.04
CIP 48.00 8.00 44.00 83.67 0.00 16.33
SMX 60.00 0.00 40.00 100.00 0.00 0.00
RMP 0.00 0.00 100.00 6.12 0.00 93.88
INH 0.00 0.00 100.00 2.04 0.00 97.96

MIC breakpoints used for categorisation of susceptibility of RGM and SGM to nine antimicrobial agents

Antimicrobial agent Range (μg/mL) MIC breakpoints (μg/mL)
RGM
 SGM
S I R S I R
AMK 1–128 ≤16 32 ≥64 - - >32
KAN 1–64 ≤16 32 ≥64 - - >32
TOB 1–64 ≤1 2–4 ≥8 - - >4
DOX 0.25–32 ≤2 4 ≥8 ≤2 4 ≥8
CLR 0.25–32 ≤2 4 ≥8 ≤8 16 ≥32
CIP 0.125–16 ≤1 2 ≥4 - - >2
SMX 1–64 ≤32 - ≥64 ≤32 - ≥64
RMP 0.25–64 - - >1 - - >1
INH 1–64 - - ≥5 - - ≥5
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