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The protective action of piperlongumine against mycobacterial pulmonary tuberculosis in its mitigation of inflammation and macrophage infiltration in male BALB/c mice


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Abreu A.C., Coqueiro A., Sultan A.R., Lemmens N., Kim H.K., Verpoorte R., van Wamel W.J.B., Simões M., Choi Y.H.: Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA. Sci Rep 2017, 7, 3777, doi: 10.1038/s41598-017-03716-7.Abreu A.C. Coqueiro A. Sultan A.R. Lemmens N. Kim H.K. Verpoorte R. van Wamel W.J.B. Simões M. Choi Y.H. Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA Sci Rep 2017 7 3777 10.1038/s41598-017-03716-7547664228630440Open DOISearch in Google Scholar

Adesina S.K., Adebayo A.S., Adesina S.K., Gröning R.: New constituents of Piper guineense fruit and leaf. Pharmazie 2003, 58, 423–425, doi: 10.1002/chin.200340213.Adesina S.K. Adebayo A.S. Adesina S.K. Gröning R. New constituents of Piper guineense fruit and leaf Pharmazie 2003 58 423 425 10.1002/chin.200340213Open DOISearch in Google Scholar

Alviano D.S., Alviano C.S.: Plant extracts: search for new alternatives to treat microbial diseases. Curr Pharm Biotechnol 2009, 10, 106–121, doi: 10.2174/138920109787048607.Alviano D.S. Alviano C.S. Plant extracts: search for new alternatives to treat microbial diseases Curr Pharm Biotechnol 2009 10 106 121 10.2174/13892010978704860719149593Open DOISearch in Google Scholar

Bilaçeroğlu S., Perim K., Büyükşirin M., Çelikten E.: Prednisolone: a beneficial and safe adjunct to antituberculosis treatment? A randomized controlled trial. Int J Tuberc Lung Dis 1999, 3, 47–54, PMID: 10094169.Bilaçeroğlu S. Perim K. Büyükşirin M. Çelikten E. Prednisolone: a beneficial and safe adjunct to antituberculosis treatment? A randomized controlled trial Int J Tuberc Lung Dis 1999 3 47 54 PMID: 10094169Search in Google Scholar

Bloch H., Sorkin E., Erlenmeyer H.: A toxic lipid component of the tubercle bacillus (cord factor). I. Isolation from petroleum ether extracts of young bacterial cultures. Am Rev Tuberc 1953, 67, 629–643, doi: 10.1164/art.1953.67.5.629.Bloch H. Sorkin E. Erlenmeyer H. A toxic lipid component of the tubercle bacillus (cord factor) I. Isolation from petroleum ether extracts of young bacterial cultures. Am Rev Tuberc 1953 67 629 643 10.1164/art.1953.67.5.62913040690Open DOISearch in Google Scholar

Bourigault M.L., Segueni N., Rose S., Court N., Vacher R., Vasseur V., Erard F. Bert M.L., Gracia I., Iwakura Y., Jacobs M., Ryffel B., Quesniaux V.F.J.: Relative contribution of IL-1α, IL-1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis B.C.G. Immun Inflamm Dis 2013, 1, 47–62, doi: 10.1002/iid3.9.Bourigault M.L. Segueni N. Rose S. Court N. Vacher R. Vasseur V. Erard F. Bert M.L. Gracia I. Iwakura Y. Jacobs M. Ryffel B. Quesniaux V.F.J. Relative contribution of IL-1α, IL-1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M bovis B.C.G. Immun Inflamm Dis 2013 1 47 62 10.1002/iid3.9421754025400917Open DOISearch in Google Scholar

Chavarria D., Silva T., Magalhães e Silva D., Remião F., Borges F.: Lessons from black pepper: piperine and derivatives thereof. Expert Opin Ther Pat 2016, 2, 245–264, doi: 10.1517/13543776.2016.1118057.Chavarria D. Silva T. Magalhães e Silva D. Remião F. Borges F. Lessons from black pepper: piperine and derivatives thereof Expert Opin Ther Pat 2016 2 245 264 10.1517/13543776.2016.111805726560940Open DOISearch in Google Scholar

Chittasupho C., Manikwar P., Krise J.P., Siahaan T.J., Berkland C.: cIBR effectively targets nanoparticles to LFA-1 on acute lymphoblastic T cells. Mol Pharm 2010, 7, 146–155, doi: 10.1021/mp900185u.Chittasupho C. Manikwar P. Krise J.P. Siahaan T.J. Berkland C. cIBR effectively targets nanoparticles to LFA-1 on acute lymphoblastic T cells Mol Pharm 2010 7 146 155 10.1021/mp900185u281513019883077Open DOISearch in Google Scholar

Chuquimia O.D., Petursdottir D.H., Periolo N., Fernández C.: Alveolar epithelial cells are critical in protection of the respiratory tract by secretion of factors able to modulate the activity of pulmonary macrophages and directly control bacterial growth. Infect Immun 2013, 81, 381–389, doi: 10.1128/IAI.00950-12.Chuquimia O.D. Petursdottir D.H. Periolo N. Fernández C. Alveolar epithelial cells are critical in protection of the respiratory tract by secretion of factors able to modulate the activity of pulmonary macrophages and directly control bacterial growth Infect Immun 2013 81 381 389 10.1128/IAI.00950-12353615823147039Open DOISearch in Google Scholar

Farberman M.M., Hoffmann J.W., Ryerse J.S., Demello D.E.: Diffusible signal to murine alveolar macrophages from lipopolysaccharide- and Escherichia coli-stimulated lung Type II epithelial cells. Inflamm Res 2004, 53, 475–483, doi: 10.1007/s00011-004-1289-6.Farberman M.M. Hoffmann J.W. Ryerse J.S. Demello D.E. Diffusible signal to murine alveolar macrophages from lipopolysaccharide- and Escherichia coli-stimulated lung Type II epithelial cells Inflamm Res 2004 53 475 483 10.1007/s00011-004-1289-615551001Open DOISearch in Google Scholar

Fenton M.J.: Macrophages and tuberculosis. Curr Opin Hematol 1998, 5, 72–78, doi: 10.1097/00062752-199801000-00012.Fenton M.J. Macrophages and tuberculosis Curr Opin Hematol 1998 5 72 78 10.1097/00062752-199801000-000129515206Open DOISearch in Google Scholar

Flynn J.L., Chan J., Lin P.L.: Macrophages and control of granulomatous inflammation in tuberculosis. Mucosal Immunol 2011, 4, 271–278, doi: 10.1038/mi.2011.14.Flynn J.L. Chan J. Lin P.L. Macrophages and control of granulomatous inflammation in tuberculosis Mucosal Immunol 2011 4 271 278 10.1038/mi.2011.14331195821430653Open DOISearch in Google Scholar

Guidry T.V., Olsen M., Kil K.S., Hunter R.L. Jr., Geng Y.J., Actor J.K.: Failure of CD1D-/- mice to elicit hypersensitive granulomas to mycobacterial cord factor trehalose 6,6'-dimycolate. J Interferon Cytokine Res 2004, 24, 362–371, doi: 10.1089/107999004323142222.Guidry T.V. Olsen M. Kil K.S. Hunter R.L. Jr. Geng Y.J. Actor J.K. Failure of CD1D-/- mice to elicit hypersensitive granulomas to mycobacterial cord factor trehalose 6,6'-dimycolate J Interferon Cytokine Res 2004 24 362 371 10.1089/10799900432314222215212710Open DOISearch in Google Scholar

Hasan A., Sadoh D., Palmer R., Foo M., Marber M., Lehner T.: The immune responses to human and microbial heat shock proteins in periodontal disease with and without coronary heart disease. Clin Exp Immunol 2005, 142, 585–594, doi: 10.1111/j.1365-2249.2005.02953.x.Hasan A. Sadoh D. Palmer R. Foo M. Marber M. Lehner T. The immune responses to human and microbial heat shock proteins in periodontal disease with and without coronary heart disease Clin Exp Immunol 2005 142 585 594 10.1111/j.1365-2249.2005.02953.x180953416297172Open DOISearch in Google Scholar

Hemaiswarya S., Kruthiventi A.K., Doble M.: Synergism between natural products and antibiotics against infectious diseases. Phytomedicine 2008, 15, 639–652, doi: 10.1016/j.phymed.2008.06.008.Hemaiswarya S. Kruthiventi A.K. Doble M. Synergism between natural products and antibiotics against infectious diseases Phytomedicine 2008 15 639 652 10.1016/j.phymed.2008.06.00818599280Open DOISearch in Google Scholar

Hunter R.L., Olsen M.R., Jagannath C., Actor J.K.: Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease. Ann Clin Lab Sci 2006, 36, 371–386, PMID: 17127724.Hunter R.L. Olsen M.R. Jagannath C. Actor J.K. Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease Ann Clin Lab Sci 2006 36 371 386 PMID: 17127724Search in Google Scholar

Kaneda K., Sumi Y., Kurano F., Kato Y., Yano I.: Granuloma formation and hemopoiesis induced by C36-48-mycolic acid-containing glycolipids from Nocardia rubra. Infect Immun 1986, 54, 869–875, doi: 10.1128/iai.54.3.869-875.1986.Kaneda K. Sumi Y. Kurano F. Kato Y. Yano I. Granuloma formation and hemopoiesis induced by C36-48-mycolic acid-containing glycolipids from Nocardia rubra Infect Immun 1986 54 869 875 10.1128/iai.54.3.869-875.19862602513781628Open DOISearch in Google Scholar

Karsha P.V., Lakshmi O.B.: Antibacterial activity of black pepper (Piper nigrum Linn.) with special reference to its mode of action on bacteria. Indian J Nat Prod Resour 2010, doi: 10.1128/IAI.68.5.2976-2978.2000.Karsha P.V. Lakshmi O.B. Antibacterial activity of black pepper (Piper nigrum Linn.) with special reference to its mode of action on bacteria Indian J Nat Prod Resour 2010 10.1128/IAI.68.5.2976-2978.20009751210768997Open DOISearch in Google Scholar

Kurashima K., Mukaida N., Fujimura M., Yasui M., Nakazumi Y., Matsuda T., Matsushima K.: Elevated chemokine levels in bronchoalveolar lavage fluid of tuberculosis patients. Am J Respir Crit Care Med 1997, 155, 1474–1477, doi: 10.1164/ajrccm.155.4.9105097.Kurashima K. Mukaida N. Fujimura M. Yasui M. Nakazumi Y. Matsuda T. Matsushima K. Elevated chemokine levels in bronchoalveolar lavage fluid of tuberculosis patients Am J Respir Crit Care Med 1997 155 1474 1477 10.1164/ajrccm.155.4.91050979105097Open DOISearch in Google Scholar

Lambert R.J.: Susceptibility testing: inoculum size dependency of inhibition using the Colworth MIC technique. J Appl Microbiol 2000, 89, 275–279, doi: 10.1046/j.1365-2672.2000.01105.x.Lambert R.J. Susceptibility testing: inoculum size dependency of inhibition using the Colworth MIC technique J Appl Microbiol 2000 89 275 279 10.1046/j.1365-2672.2000.01105.x10971759Open DOISearch in Google Scholar

Lee W.-B., Kang J.-S., Yan J.-J., Lee M.S., Jeon B.-Y., Cho S.-N., Kim Y.-J.: Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway. PLoS Pathog 2012, 8, e1002614, doi: 10.1371/journal.ppat.1002614.Lee W.-B. Kang J.-S. Yan J.-J. Lee M.S. Jeon B.-Y. Cho S.-N. Kim Y.-J. Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway PLoS Pathog 2012 8 e1002614 10.1371/journal.ppat.1002614332058922496642Open DOISearch in Google Scholar

Mgbeahuruike E.E., Yrjönen T., Vuorela H., Holm Y.: Bioactive compounds from medicinal plants: Focus on Piper species. S Afr J Bot 2017, 112, 54–69, doi: 10.1016/j.sajb.2017.05.007.Mgbeahuruike E.E. Yrjönen T. Vuorela H. Holm Y. Bioactive compounds from medicinal plants: Focus on Piper species S Afr J Bot 2017 112 54 69 10.1016/j.sajb.2017.05.007Open DOISearch in Google Scholar

Mirza Z.M., Kumar A., Kalia N.P., Zargar A., Khan I.A.: Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus. J Med Microbiol 2011, 60, 1472–1478, doi: 10.1099/jmm.0.033167-0.Mirza Z.M. Kumar A. Kalia N.P. Zargar A. Khan I.A. Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus J Med Microbiol 2011 60 1472 1478 10.1099/jmm.0.033167-021680766Open DOISearch in Google Scholar

Mohammed K.A., Nasreen N., Ward M.J., Mubarak K.K., Rodriguez-Panadero F., Antony V.B.: Mycobacterium-mediated chemokine expression in pleural mesothelial cells: role of C-C chemokines in tuberculous pleurisy. J Infect Dis 1998, 178, 1450–1456, doi: 10.1086/314442.Mohammed K.A. Nasreen N. Ward M.J. Mubarak K.K. Rodriguez-Panadero F. Antony V.B. Mycobacterium-mediated chemokine expression in pleural mesothelial cells: role of C-C chemokines in tuberculous pleurisy J Infect Dis 1998 178 1450 1456 10.1086/3144429780267Open DOISearch in Google Scholar

Naika R., Prasanna K., Ganapathy P.J.P.: Antibacterial activity of piperlongumine an alkaloid isolated from methanolic root extract of Piper longum L. Pharmacophore 2010, 1, 141–148.Naika R. Prasanna K. Ganapathy P.J.P. Antibacterial activity of piperlongumine an alkaloid isolated from methanolic root extract of Piper longum L Pharmacophore 2010 1 141 148Search in Google Scholar

Orme I.M., Robinson R.T., Cooper A.M.: The balance between protective and pathogenic immune responses in the TB-infected lung. Nat Immunol 2015, 16, 57–63, doi: 10.1038/ni.3048.Orme I.M. Robinson R.T. Cooper A.M. The balance between protective and pathogenic immune responses in the TB-infected lung Nat Immunol 2015 16 57 63 10.1038/ni.304825521685Open DOISearch in Google Scholar

Hernando-Amado S., Alcalde-Rico M., Gil-Gil T., Valverde J.R., Martínez J.L.: Naringenin Inhibition of the Pseudomonas aeruginosa Quorum Sensing Response Is Based on Its Time-Dependent Competition With N-(3-Oxo-dodecanoyl)-L-homoserine Lactone for LasR Binding. Front Mol Biosci 2020, 7, 25, doi: 10.3389/fmolb.2020.00025.Hernando-Amado S. Alcalde-Rico M. Gil-Gil T. Valverde J.R. Martínez J.L. Naringenin Inhibition of the Pseudomonas aeruginosa Quorum Sensing Response Is Based on Its Time-Dependent Competition With N-(3-Oxo-dodecanoyl)-L-homoserine Lactone for LasR Binding Front Mol Biosci 2020 7 25 10.3389/fmolb.2020.00025705912832181260Open DOISearch in Google Scholar

Ozeki Y., Tsutsui H., Kawada N., Suzuki H., Kataoka M., Kodama T., Yano I., Kaneka K., Kobayashi K.: Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages. Microb Pathog 2006, 40, 171–176, doi: 10.1016/j.micpath.2005.12.006.Ozeki Y. Tsutsui H. Kawada N. Suzuki H. Kataoka M. Kodama T. Yano I. Kaneka K. Kobayashi K. Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages Microb Pathog 2006 40 171 176 10.1016/j.micpath.2005.12.00616517114Open DOISearch in Google Scholar

Philipova I., Valcheva V., Mihaylova R., Mateeva M., Doytchinova I., Stavrakov G.: Synthetic piperine amide analogs with antimycobacterial activity. Chem Biol Drug Des 2018, 91, 763–768, doi: 10.1111/cbdd.13140.Philipova I. Valcheva V. Mihaylova R. Mateeva M. Doytchinova I. Stavrakov G. Synthetic piperine amide analogs with antimycobacterial activity Chem Biol Drug Des 2018 91 763 768 10.1111/cbdd.1314029130602Open DOISearch in Google Scholar

Piska K., Gunia-Krzyżak A., Koczurkiewicz P., Wójcik-Pszczoła K., Pękala E.: Piperlongumine (piplartine) as a lead compound for anticancer agents – Synthesis and properties of analogues: A mini-review. Eur J Med Chem 2018, 156, 13–20, doi: 10.1016/j.ejmech.2018.06.057.Piska K. Gunia-Krzyżak A. Koczurkiewicz P. Wójcik-Pszczoła K. Pękala E. Piperlongumine (piplartine) as a lead compound for anticancer agents – Synthesis and properties of analogues: A mini-review Eur J Med Chem 2018 156 13 20 10.1016/j.ejmech.2018.06.05730006159Open DOISearch in Google Scholar

Ramakrishnan L.: Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol 2012, 12, 352–366, doi: 10.1038/nri3211.Ramakrishnan L. Revisiting the role of the granuloma in tuberculosis Nat Rev Immunol 2012 12 352 366 10.1038/nri321122517424Open DOISearch in Google Scholar

Sadek M.I., Sada E., Toossi Z., Schwander S.K., Rich E.A.: Chemokines induced by infection of mononuclear phagocytes with mycobacteria and present in lung alveoli during active pulmonary tuberculosis. Am J Respir Cell Mol Biol 1998, 19, 513–521, doi: 10.1165/ajrcmb.19.3.2815.Sadek M.I. Sada E. Toossi Z. Schwander S.K. Rich E.A. Chemokines induced by infection of mononuclear phagocytes with mycobacteria and present in lung alveoli during active pulmonary tuberculosis Am J Respir Cell Mol Biol 1998 19 513 521 10.1165/ajrcmb.19.3.28159730880Open DOISearch in Google Scholar

Sakamoto K.: The pathology of Mycobacterium tuberculosis infection. Vet Pathol 2012, 49, 423–439, doi: 10.1177/0300985811429313.Sakamoto K. The pathology of Mycobacterium tuberculosis infection Vet Pathol 2012 49 423 439 10.1177/030098581142931322262351Open DOISearch in Google Scholar

Sasindran S.J., Torrelles J.B.: Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium? Front Microbiol 2011, 2, 2, doi: 10.3389/fmicb.2011.00002.Sasindran S.J. Torrelles J.B. Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium? Front Microbiol 2011 2 2 10.3389/fmicb.2011.00002310928921687401Open DOISearch in Google Scholar

Schoenen H., Bodendorfer B., Hitchens K., Manzanero S., Werninghaus K., Nimmerjahn F., Agger E.M., Stenger S., Andersen P., Ruland J., Brown G.D., Wells C.H., Lang R.: Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol 2010, 184, 2756–2760, doi: 10.4049/jimmunol.0904013.Schoenen H. Bodendorfer B. Hitchens K. Manzanero S. Werninghaus K. Nimmerjahn F. Agger E.M. Stenger S. Andersen P. Ruland J. Brown G.D. Wells C.H. Lang R. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate J Immunol 2010 184 2756 2760 10.4049/jimmunol.0904013344233620164423Open DOISearch in Google Scholar

Stavri M., Piddock L.J., Gibbons S.: Bacterial efflux pump inhibitors from natural sources. J Antimicrob Chemother 2007, 59, 1247–1260, doi: 10.1093/jac/dkl460.Stavri M. Piddock L.J. Gibbons S. Bacterial efflux pump inhibitors from natural sources J Antimicrob Chemother 2007 59 1247 1260 10.1093/jac/dkl46017145734Open DOISearch in Google Scholar

Subramani R., Narayanasamy M., Feussner K.D.: Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens. 3 Biotech 2017, 7, 172, doi: 10.1007/s13205-017-0848-9.Subramani R. Narayanasamy M. Feussner K.D. Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens 3 Biotech 2017 7 172 10.1007/s13205-017-0848-9548945528660459Open DOISearch in Google Scholar

Sunil V.R., Patel K.J., Nilsen-Hamilton M., Heck D.E., Laskin J.D., Laskin D.L.: Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Exp Mol Pathol 2007, 83, 177–187, doi: 10.1016/j.yexmp.2007.03.004.Sunil V.R. Patel K.J. Nilsen-Hamilton M. Heck D.E. Laskin J.D. Laskin D.L. Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver Exp Mol Pathol 2007 83 177 187 10.1016/j.yexmp.2007.03.004395412517490638Open DOISearch in Google Scholar

Tao F., Kobzik L.: Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release. Am J Respir Cell Mol Biol 2002, 26, 499–505, doi: 10.1165/ajrcmb.26.4.4749.Tao F. Kobzik L. Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release Am J Respir Cell Mol Biol 2002 26 499 505 10.1165/ajrcmb.26.4.474911919087Open DOISearch in Google Scholar

Tegos G., Stermitz F.R., Lomovskaya O., Lewis K.: Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob Agents Chemother 2002, 46, 3133–3141, doi: 10.1128/AAC.46.10.3133-3141.2002.Tegos G. Stermitz F.R. Lomovskaya O. Lewis K. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials Antimicrob Agents Chemother 2002 46 3133 3141 10.1128/AAC.46.10.3133-3141.200212877712234835Open DOISearch in Google Scholar

Tsao T.C., Hong J., Huang C., Yang P., Liao S.K., Chang K.S.: Increased TNF-alpha, IL-1 beta and IL-6 levels in the bronchoalveolar lavage fluid with the upregulation of their mRNA in macrophages lavaged from patients with active pulmonary tuberculosis. Tuber Lung Dis 1999, 79, 279–285, doi: 10.1054/tuld.1999.0215.Tsao T.C. Hong J. Huang C. Yang P. Liao S.K. Chang K.S. Increased TNF-alpha, IL-1 beta and IL-6 levels in the bronchoalveolar lavage fluid with the upregulation of their mRNA in macrophages lavaged from patients with active pulmonary tuberculosis Tuber Lung Dis 1999 79 279 285 10.1054/tuld.1999.021510707256Open DOISearch in Google Scholar

Van Vuuren S.F., Suliman S., Viljoen A.M.: The antimicrobial activity of four commercial essential oils in combination with conventional antimicrobials. Lett Appl Microbiol 2009, 48, 440–446, doi: 10.1111/j.1472-765X.2008.02548.x.Van Vuuren S.F. Suliman S. Viljoen A.M. The antimicrobial activity of four commercial essential oils in combination with conventional antimicrobials Lett Appl Microbiol 2009 48 440 446 10.1111/j.1472-765X.2008.02548.x19187494Open DOISearch in Google Scholar

Wei L., Wu J., Liu H., Yang H., Rong M., Li D., Zhang P., Han J., Lai R.: A mycobacteriophage-derived trehalose-6,6’-dimycolate-binding peptide containing both antimycobacterial and anti-inflammatory abilities. FASEB J 2013, 27, 3067–3077, doi: 10.1096/fj.13-227454.Wei L. Wu J. Liu H. Yang H. Rong M. Li D. Zhang P. Han J. Lai R. A mycobacteriophage-derived trehalose-6,6’-dimycolate-binding peptide containing both antimycobacterial and anti-inflammatory abilities FASEB J 2013 27 3067 3077 10.1096/fj.13-22745423603838Open DOISearch in Google Scholar

Yang S.-K., Low L.-Y., Yap P.S.-X., Yusoff K., Mai C.-W., Lai K.-S.: Plant-Derived Antimicrobials: Insights into Mitigation of Antimicrobial Resistance. Rec Nat Prod 2018, 12, 295–316, doi: 10.25135/rnp.41.17.09.058.Yang S.-K. Low L.-Y. Yap P.S.-X. Yusoff K. Mai C.-W. Lai K.-S. Plant-Derived Antimicrobials: Insights into Mitigation of Antimicrobial Resistance Rec Nat Prod 2018 12 295 316 10.25135/rnp.41.17.09.058Open DOISearch in Google Scholar

Yi Y.-S., Son Y.-J., Ryou C., Sung G.-H., Kim J.-H., Cho J.Y.: Functional roles of Syk in macrophage-mediated inflammatory responses. Mediators Inflamm 2014, 270302, doi: 10.1155/2014/270302.Yi Y.-S. Son Y.-J. Ryou C. Sung G.-H. Kim J.-H. Cho J.Y. Functional roles of Syk in macrophage-mediated inflammatory responses Mediators Inflamm 2014 270302 10.1155/2014/270302409044725045209Open DOISearch in Google Scholar

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