<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jvetres-2020-0048_s_005">
<h3>Introduction</h3>
<p>Coinfection of goose parvovirus (GPV) and duck circovirus (DuCV) occurs commonly in field cases of short beak and dwarfism syndrome (SBDS). However, whether there is synergism between the two viruses in replication and pathogenicity remains undetermined.</p></sec>
<sec id="j_jvetres-2020-0048_s_006">
<h3>Material and Methods</h3>
<p>We established a coinfection model of GPV and DuCV in Cherry Valley ducks. Tissue samples were examined histopathologically. The viral loads in tissues were detected by qPCR, and the distribution of the virus in tissues was detected by immunohistochemistry (IHC).</p></sec>
<sec id="j_jvetres-2020-0048_s_007">
<h3>Results</h3>
<p>Coinfection of GPV and DuCV significantly inhibited growth and development of ducks, and caused atrophy and pallor of the immune organs and necrosis of the liver. GPV and DuCV synergistically amplified pathogenicity in coinfected ducks. In the early stage of infection, viral loads of both pathogens in coinfected ducks were significantly lower than those in monoinfected ducks (P &lt; 0.05). With the development of the infection process, GPV and DuCV loads in coinfected ducks were significantly higher than those in monoinfected ducks (P &lt; 0.05). Extended viral distribution in the liver, kidney, duodenum, spleen, and bursa of Fabricius was consistent with the viral load increases in GPV and DuCV coinfected ducks.</p></sec>
<sec id="j_jvetres-2020-0048_s_008">
<h3>Conclusion</h3>
<p>These results indicate that GPV and DuCV synergistically potentiate their replication and pathogenicity in coinfected ducks.</p></sec>
</abstract>

Introduction
Coinfection of goose parvovirus (GPV) and duck circovirus (DuCV) occurs commonly in field cases of short beak and dwarfism syndrome (SBDS). However, whether there is synergism between the two viruses in replication and pathogenicity remains undetermined.

Material and Methods
We established a coinfection model of GPV and DuCV in Cherry Valley ducks. Tissue samples were examined histopathologically. The viral loads in tissues were detected by qPCR, and the distribution of the virus in tissues was detected by immunohistochemistry (IHC).

Results
Coinfection of GPV and DuCV significantly inhibited growth and development of ducks, and caused atrophy and pallor of the immune organs and necrosis of the liver. GPV and DuCV synergistically amplified pathogenicity in coinfected ducks. In the early stage of infection, viral loads of both pathogens in coinfected ducks were significantly lower than those in monoinfected ducks (P < 0.05). With the development of the infection process, GPV and DuCV loads in coinfected ducks were significantly higher than those in monoinfected ducks (P < 0.05). Extended viral distribution in the liver, kidney, duodenum, spleen, and bursa of Fabricius was consistent with the viral load increases in GPV and DuCV coinfected ducks.

Conclusion
These results indicate that GPV and DuCV synergistically potentiate their replication and pathogenicity in coinfected ducks.

Effect of goose parvovirus and duck circovirus coinfection in ducks

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Effect of goose parvovirus and duck circovirus coinfection in ducks"}

Introduction
Coinfection of goose parvovirus (GPV) and duck circovirus (DuCV) occurs commonly in field cases of short beak and dwarfism syndrome (SBDS)....

Effect of goose parvovirus and duck circovirus coinfection in ducks

Published Online: Jul 14, 2020

Page range: 355 - 361

Received: Dec 02, 2019

Accepted: Jun 26, 2020

DOI: https://doi.org/10.2478/jvetres-2020-0048

Keywords
goose parvovirus, duck circovirus, synergism, viral replication, pathogenicity

© 2020 J. Liu et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effect of goose parvovirus and duck circovirus coinfection in ducks

Published Online: Jul 14, 2020

Page range: 355 - 361

Received: Dec 02, 2019

Accepted: Jun 26, 2020

DOI: https://doi.org/10.2478/jvetres-2020-0048

Keywordsgoose parvovirus, duck circovirus, synergism, viral replication, pathogenicity

© 2020 J. Liu et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
goose parvovirus, duck circovirus, synergism, viral replication, pathogenicity