<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jvetres-2019-0054_s_005">
<h3>Introduction</h3>
<p>The aim of this study was to evaluate potential protective effects of propolis on furan-induced hepatic damage by assessing the levels of malondialdehyde (MDA) and reduced glutathione (GSH), antioxidant enzyme activities, and histopathological changes in the liver.</p></sec>
<sec id="j_jvetres-2019-0054_s_006">
<h3>Material and Methods</h3>
<p>Albino Wistar rats were divided into six groups: a control, propolis-treated (100 mg/kg b.w./day), low-dose furan-treated (furan-L group; 2 mg/kg b.w./day), high-dose furan-treated (furan-H group; 16 mg/kg b.w./day), furan-L+propolis treated, and furan-H+propolis treated group. Propolis and furan were applied by gavage; propolis for 8 days, and furan for 20 days in furan-L groups and 10 days in furan-H groups.</p></sec>
<sec id="j_jvetres-2019-0054_s_007">
<h3>Results</h3><p>While MDA levels were elevated in furan-treated groups, levels of GSH and activities of antioxidant enzymes decreased (p &lt; 0.001). The levels of MDA and GSH and activities of antioxidant enzymes were normal in the furan+propolis groups, especially in the furan-L+propolis group (p &lt; 0.001). While the aspartate transaminase, alanine transaminase, alkaline phosphatase, and lactate pdehydrogenase activities were elevated in the furan-H treated group (p &lt; 0.05 and p &lt; 0.001), they were unchanged in the furan-L treated group. Histopathologically, several lesions were observed in the liver tissues of the furan-treated groups, especially in the higher-dose group. It was determined that these changes were milder in both of the furan+propolis groups.</p></sec>
<sec id="j_jvetres-2019-0054_s_008">
<h3>Conclusion</h3>
<p>The results indicate that propolis exhibits good hepatoprotective and antioxidant potential against furan-induced hepatocellular damage in rats.</p></sec></abstract>

Introduction
The aim of this study was to evaluate potential protective effects of propolis on furan-induced hepatic damage by assessing the levels of malondialdehyde (MDA) and reduced glutathione (GSH), antioxidant enzyme activities, and histopathological changes in the liver.

Material and Methods
Albino Wistar rats were divided into six groups: a control, propolis-treated (100 mg/kg b.w./day), low-dose furan-treated (furan-L group; 2 mg/kg b.w./day), high-dose furan-treated (furan-H group; 16 mg/kg b.w./day), furan-L+propolis treated, and furan-H+propolis treated group. Propolis and furan were applied by gavage; propolis for 8 days, and furan for 20 days in furan-L groups and 10 days in furan-H groups.

ResultsWhile MDA levels were elevated in furan-treated groups, levels of GSH and activities of antioxidant enzymes decreased (p < 0.001). The levels of MDA and GSH and activities of antioxidant enzymes were normal in the furan+propolis groups, especially in the furan-L+propolis group (p < 0.001). While the aspartate transaminase, alanine transaminase, alkaline phosphatase, and lactate pdehydrogenase activities were elevated in the furan-H treated group (p < 0.05 and p < 0.001), they were unchanged in the furan-L treated group. Histopathologically, several lesions were observed in the liver tissues of the furan-treated groups, especially in the higher-dose group. It was determined that these changes were milder in both of the furan+propolis groups.

Conclusion
The results indicate that propolis exhibits good hepatoprotective and antioxidant potential against furan-induced hepatocellular damage in rats.

Protective role of propolis on low and high dose furan-induced hepatotoxicity and oxidative stress in rats

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction
The aim of this study was to evaluate potential protective effects of propolis on furan-induced hepatic damage by assessing the levels of...

Protective role of propolis on low and high dose furan-induced hepatotoxicity and oxidative stress in rats

Published Online: Sep 13, 2019

Page range: 423 - 431

Received: Feb 13, 2019

Accepted: Aug 12, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0054

Keywords
rats, furan, hepatotoxicity, oxidative stress, propolis

© 2019 E. Kaya et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Protective role of propolis on low and high dose furan-induced hepatotoxicity and oxidative stress in rats

Published Online: Sep 13, 2019

Page range: 423 - 431

Received: Feb 13, 2019

Accepted: Aug 12, 2019

DOI: https://doi.org/10.2478/jvetres-2019-0054

Keywordsrats, furan, hepatotoxicity, oxidative stress, propolis

© 2019 E. Kaya et al. published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
rats, furan, hepatotoxicity, oxidative stress, propolis