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Influence of inosine pranobex on cell viability in normal fibroblasts and liver cancer cells

Sylwia Tobólska

Sylwia Tobólska

Lublin, Poland
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Tobólska, Sylwia
, 
Sylwia Terpiłowska

Sylwia Terpiłowska

Laboratory of Environmental Biology, Institute of Environmental Engineering, The John Paul II Catholic University of LublinLublin, Poland
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Terpiłowska, Sylwia
, 
Jerzy Jaroszewski

Jerzy Jaroszewski

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in OlsztynOlsztyn, Poland
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Jaroszewski, Jerzy
 and 
Andrzej Krzysztof Siwicki

Andrzej Krzysztof Siwicki

Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury in OlsztynOlsztyn, Poland
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Siwicki, Andrzej Krzysztof
  
Jul 07, 2018
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Published Online: Jul 07, 2018
Page range: 215 - 220
Received: Mar 29, 2018
Accepted: Jun 21, 2018
DOI: https://doi.org/10.2478/jvetres-2018-0031
Keywords
© 2018 Sylwia Tobólska et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1

Cytotoxicity of inosine pranobex in BALB/ 3T3 clone A31 and HepG2 lines detected with the MTT assay, n = 6. Values are given as percentage of cell viability relative to control cells. *P < 0.05, compared with control cells
Cytotoxicity of inosine pranobex in BALB/ 3T3 clone A31 and HepG2 lines detected with the MTT assay, n = 6. Values are given as percentage of cell viability relative to control cells. *P < 0.05, compared with control cells

Fig. 2

Cytotoxicity of inosine pranobex in BALB/3T3 clone A31 and HepG2 lines detected with the LDH assay, n = 6. Values are given as percentage of LDH released. *P < 0.05, compared with control cells
Cytotoxicity of inosine pranobex in BALB/3T3 clone A31 and HepG2 lines detected with the LDH assay, n = 6. Values are given as percentage of LDH released. *P < 0.05, compared with control cells

Fig. 3

Cytotoxicity of inosine pranobex in BALB/3T3 clone A31 and HepG2 lines detected with the NRU assay, n = 6. Values are given as percentage of cell viability relative to control cells. *P < 0.05, compared with control cells
Cytotoxicity of inosine pranobex in BALB/3T3 clone A31 and HepG2 lines detected with the NRU assay, n = 6. Values are given as percentage of cell viability relative to control cells. *P < 0.05, compared with control cells

Cytotoxicity of inosine pranobex_ Inhibitory concentration (IC50, μg/mL)

BALB/ 3T3 clone A31 lineHepG2 line
MTT reduction assay50050
LDH release assay10010
NRU assay500100
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English
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Life Sciences, Molecular Biology, Microbiology and Virology, Life Sciences, other, Medicine, Veterinary Medicine
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