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Histopathological, immunohistochemical, and parasitological studies on pathogenesis of Coenurus cerebralis in sheep

Yilmaz Rahsan

Yilmaz Rahsan

Department of Pathology, Faculty of Veterinary Medicine, Harran UniversitySanliurfa, Turkey
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Rahsan, Yilmaz
, 
Yumusak Nihat

Yumusak Nihat

Department of Pathology, Faculty of Veterinary Medicine, Harran UniversitySanliurfa, Turkey
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Nihat, Yumusak
, 
Yilmaz Bestami

Yilmaz Bestami

Department of Anatomy, Faculty of Veterinary Medicine, Harran UniversitySanliurfa, Turkey
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Bestami, Yilmaz
, 
Ayan Adnan

Ayan Adnan

Department of Genetics, Faculty of Veterinary Medicine, Yuzuncu Yıl UniversityVan, Turkey
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Adnan, Ayan
 and 
Aysul Nuran

Aysul Nuran

Department of Parasitology, Faculty of Veterinary Medicine, Adnan Menderes UniversityAydin, Turkey
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Nuran, Aysul
  
Mar 30, 2018
Histopathological, immunohistochemical, and parasitological studies on pathogenesis of Coenurus cerebralis in sheep's Cover Image
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Published Online: Mar 30, 2018
Page range: 35 - 41
Received: Dec 19, 2017
Accepted: Mar 09, 2018
DOI: https://doi.org/10.2478/jvetres-2018-0005
Keywords
© 2018 Y. Rahsan et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction

This study consisted in histopathological and immunohistochemical examinations of the central nervous system of 15 sheep suspected of infection with Coenurus cerebralis. The sheep displayed compulsive circling and were submitted for necropsy in 2012–2016.

Material and Methods

Species identification was made on the basis of the PCR analysis and parasitological examination of the cysts.

Results

Coenurus cerebralis cysts were detected only in the cerebral tissue of 13 sheep and in the cerebral and cerebellar tissues of 2 animals. Out of the 33 parasite cysts, most (21.21%) were located in the right and left frontal lobes of the cerebrum. The largest cyst measured 6 × 5 cm and the smallest cyst was 2 × 2 cm in size. The highest and lowest numbers of scolices were 55 and 21, and the number of rostellar hooks ranged between 22 and 30. Histopathological examination revealed the presence of typical parasitic granulomatous inflammatory foci. Immunohistochemical staining showed that most common in the periphery of the parasite cysts were, in descending order by cell number, GFAP, CD163, CD3, and CD79α-positive cells.

Conclusion

The study confirms the role of cellular defence mechanisms in the pathogenesis of Coenurus cerebralis infection in sheep.
Language:
English
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4 times per year
Journal Subjects:
Life Sciences, Molecular Biology, Microbiology and Virology, Life Sciences, other, Medicine, Veterinary Medicine
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