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Electrical impedance myography as a marker of muscle mass in rats with simulated Anorexia Nervosa

Megan E. Rosa-Caldwell

Megan E. Rosa-Caldwell

  • Energy Availability and Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Health, Human Performance, and Recreation, University of ArkansasFayetteville,
  • Beth Israel Deaconess Medical Center and Harvard Medical School, Department of NeurologyBoston,
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Rosa-Caldwell, Megan E.
, 
Buket Sonbas Cobb

Buket Sonbas Cobb

  • Beth Israel Deaconess Medical Center and Harvard Medical School, Department of NeurologyBoston,
  • Department of Electrical and Electronic Engineering, Harran UniversitySanliurfa, Turkey
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Cobb, Buket Sonbas
, 
Lauren Breithaupt

Lauren Breithaupt

  • Department of Psychiatry, Harvard Medical School, Eating Disorders Clinical and Research Program, Massachusetts General HospitalBoston,
  • Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Mass General BrighamBoston,
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Breithaupt, Lauren
 and 
Seward B. Rutkove

Seward B. Rutkove

Beth Israel Deaconess Medical Center and Harvard Medical School, Department of NeurologyBoston,
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Rutkove, Seward B.
  
Aug 06, 2025
Electrical impedance myography as a marker of muscle mass in rats with simulated Anorexia Nervosa's Cover Image
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Published Online: Aug 06, 2025
Page range: 107 - 114
Received: Apr 30, 2025
DOI: https://doi.org/10.2478/joeb-2025-0014
Keywords
© 2025 Megan E. Rosa-Caldwell et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1:

Phenotypic data from short term recovery and long-term recovery following simulated anorexia nervosa (AN) and recovery interventions of five days (AN-5R) and fifteen days (AN-15R) compared to healthy controls (CON). A) Bodyweight following short-term recovery, B) Gastrocnemius weight following short-term recovery, C) Plantar flexion area under the curve (AUC) of maximal tetanus following short-term recovery. D) Bodyweight following long-term recovery from simulated AN (AN_30 Day Rec) and age-matched controls (CON_30 Day Rec) E) Gastrocnemius weight following long-term recovery, F) Plantar flexion area under the curve (AUC) of maximal tetanus following long-term recovery. Data are presented as Mean ± SEM, different letters represent statistically different means at p<0.05, * p<0.05, n=10–11/group.
Phenotypic data from short term recovery and long-term recovery following simulated anorexia nervosa (AN) and recovery interventions of five days (AN-5R) and fifteen days (AN-15R) compared to healthy controls (CON). A) Bodyweight following short-term recovery, B) Gastrocnemius weight following short-term recovery, C) Plantar flexion area under the curve (AUC) of maximal tetanus following short-term recovery. D) Bodyweight following long-term recovery from simulated AN (AN_30 Day Rec) and age-matched controls (CON_30 Day Rec) E) Gastrocnemius weight following long-term recovery, F) Plantar flexion area under the curve (AUC) of maximal tetanus following long-term recovery. Data are presented as Mean ± SEM, different letters represent statistically different means at p<0.05, * p<0.05, n=10–11/group.

Figure 2:

Longitudinal Electrical Impedance Myography (EIM) data at 50Hz in rats undergoing simulated anorexia nervosa (AN) or healthy controls (CON). A) Phase, B) Reactance, C) Resistance. Data are presented as Mean ± SEM, * p<0.05, n=10–11/group.
Longitudinal Electrical Impedance Myography (EIM) data at 50Hz in rats undergoing simulated anorexia nervosa (AN) or healthy controls (CON). A) Phase, B) Reactance, C) Resistance. Data are presented as Mean ± SEM, * p<0.05, n=10–11/group.

Figure 3:

Longitudinal Electrical Impedance Myography (EIM) data at 50Hz in rats undergoing simulated anorexia nervosa followed by a recovery intervention to restore bodyweight (AN_30 Day Rec) or healthy age-matched controls (CON_30 Day Rec). A) Phase, B) Reactance, C) Resistance. Data are presented as Mean ± SEM, * p<0.05, n=10–11/group.
Longitudinal Electrical Impedance Myography (EIM) data at 50Hz in rats undergoing simulated anorexia nervosa followed by a recovery intervention to restore bodyweight (AN_30 Day Rec) or healthy age-matched controls (CON_30 Day Rec). A) Phase, B) Reactance, C) Resistance. Data are presented as Mean ± SEM, * p<0.05, n=10–11/group.

Figure 4:

Cross-sectional Electrical Impedance Myography (EIM) data at 50Hz in rats undergoing simulated anorexia nervosa (AN), healthy controls (CON) or rats undergoing five days (AN-5R) or fifteen days (AN-15R) of recovery. A) Phase, B) Reactance, C) Resistance. Data are presented as Mean ± SEM, different letters represent statistical differences at p<0.05, n=10–11/group.
Cross-sectional Electrical Impedance Myography (EIM) data at 50Hz in rats undergoing simulated anorexia nervosa (AN), healthy controls (CON) or rats undergoing five days (AN-5R) or fifteen days (AN-15R) of recovery. A) Phase, B) Reactance, C) Resistance. Data are presented as Mean ± SEM, different letters represent statistical differences at p<0.05, n=10–11/group.

Figure 5:

Top three correlations between Electrical Impedance Myography (EIM) parameters and gastrocnemius mass. A) 100 kHz Resistance, B) 79 kHz Resistance, and C) 125 kHz Resistance, n=10–11/group.
Top three correlations between Electrical Impedance Myography (EIM) parameters and gastrocnemius mass. A) 100 kHz Resistance, B) 79 kHz Resistance, and C) 125 kHz Resistance, n=10–11/group.
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Engineering, Bioengineering and Biomedical Engineering, Biomedical Electronics, Life Sciences, Biophysics, Medicine, Biomedical Engineering, Physics, Spectroscopy and Metrology
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