<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Background:</bold> Low-grade chronic inflammation is an important feature of chronic kidney disease (CKD).
<bold>Aim:</bold> To determine the values of C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with different stages of CKD and to examine how they change depending on the progression of renal damage.
<bold>Materials and methods:</bold> A cross-sectional descriptive comparative study included 157 subjects at different stages of CKD which was assessed based on glomerular filtration rate (GFR) calculated according to the MDRD equation. CRP was analyzed by an immunoturbidimetric method. NLR and PLR were calculated by a mathematical calculation after a blood count was performed.
<bold>Results:</bold> The present study showed an increase in serum creatinine, CRP, and NLR values with progression of renal failure. There was a statistically significant difference in the creatinine and CRP concentrations between groups with different stages of CKD (p &lt;0.001 for all comparisons). A significant positive correlation was found between NLR and CRP, while negative, significant correlations were observed between NLR and eGFR as well as between PLR and eGFR. There was a slight increase in PLR value with the progression of renal impairment, but the correlation between PLR and CRP was not significant.
<bold>Conclusion:</bold> These results suggest that NLR, together with CRP, may serve as an indicator of systemic low-grade inflammation progression in patients with CKD. Larger prospective studies are required to observe the possibility of using NLR as a surrogate marker for CRP in patients with CKD.
</abstract>

Background: Low-grade chronic inflammation is an important feature of chronic kidney disease (CKD).
Aim: To determine the values of C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with different stages of CKD and to examine how they change depending on the progression of renal damage.
Materials and methods: A cross-sectional descriptive comparative study included 157 subjects at different stages of CKD which was assessed based on glomerular filtration rate (GFR) calculated according to the MDRD equation. CRP was analyzed by an immunoturbidimetric method. NLR and PLR were calculated by a mathematical calculation after a blood count was performed.
Results: The present study showed an increase in serum creatinine, CRP, and NLR values with progression of renal failure. There was a statistically significant difference in the creatinine and CRP concentrations between groups with different stages of CKD (p <0.001 for all comparisons). A significant positive correlation was found between NLR and CRP, while negative, significant correlations were observed between NLR and eGFR as well as between PLR and eGFR. There was a slight increase in PLR value with the progression of renal impairment, but the correlation between PLR and CRP was not significant.
Conclusion: These results suggest that NLR, together with CRP, may serve as an indicator of systemic low-grade inflammation progression in patients with CKD. Larger prospective studies are required to observe the possibility of using NLR as a surrogate marker for CRP in patients with CKD.

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

Department of Clinical Biochemistry with Immunology

Clinical Center of the University of Sarajevo

Department of Pathophysiology, Faculty of Medicine

Department of Epidemiology and Biostatistics, Faculty of Medicine

Department of Human Physiology, Faculty of Medicine

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background: Low-grade chronic inflammation is an important feature of chronic kidney disease (CKD).
Aim: To determine the values of C-reactive protein (CRP),...

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

Published Online: Mar 08, 2023

Page range: 81 - 87

Received: Sep 01, 2022

Accepted: Dec 19, 2022

DOI: https://doi.org/10.2478/jim-2022-0019

Keywords
C-reactive protein, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, chronic kidney disease

© 2022 Nermina Klapuh-Bukvić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

Published Online: Mar 08, 2023

Page range: 81 - 87

Received: Sep 01, 2022

Accepted: Dec 19, 2022

DOI: https://doi.org/10.2478/jim-2022-0019

KeywordsC-reactive protein, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, chronic kidney disease

© 2022 Nermina Klapuh-Bukvić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
C-reactive protein, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, chronic kidney disease