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Metoprolol Use in Hypertensive Pregnancy Disorder – a Single-center Study

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Mar 28, 2025

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Pro-atherogenic and prothrombotic mechanisms of Lp(a)4

Variables All patients (n = 80) With metoprolol (n = 40) Without metoprolol (n = 40) p value
Age (years), mean ± s.d. 26.8 ± 4.54 25.90 ± 4.67 27.80 ± 4.25 0.67
Gestational week at delivery, mean ± s.d. 37.61 ± 1.17 37.20 ± 1.41 38.03 ± 0.66 0.06
Birth weight, mean ± s.d. 2,787.87 ± 356.09 2,746.50 ± 379.99 2,829.25 ± 330.06 0.30
Body mass index, n (%) 34 (42.5) 12 (30.0) 22 (55.0) 0.041
Urban environment, n (%) 65 (81.2) 36 (90.0) 29 (72.5) 0.083
Preeclampsia, n (%) 67 (83.8) 38 (95.0) 29 (72.5) 0.006
Prematurity, n (%) 5 (6.2) 5 (12.5) 0 (0.0) 0.021
IUGR, n (%) 8 (10.0) 4 (10.0) 4 (10.0) 0.98
Cesarean section 72 (90.0) 37 (92.5) 35 (87.5) 0.71
Doppler changes in the 3rd trimester 35 (43.8) 18 (45.0) 17 (42.5) 0.82
Oligoamnios 6 (7.5) 4 (10.0) 2 (5.0) 0.39
CTG affected before birth 27 (33.8) 17 (42.5) 10 (25.0) 0.15
Male sex, n (%) 21 (26.2) 11 (27.5) 10 (25.0) 0.79
G1, n (%) 53 (66.2) 27 (67.5) 26 (65.0) 0.96
G2, n (%) 23 (28.7) 11 (27.5) 12 (30.0)
G2, n (%) 4 (5.0) 5 (5.0) 2 (5.0)
P1, n (%) 70 (87.5) 34 (85.0) 36 (90.0) 0.73
P2, n (%) 10 (12.5) 6 (15.0) 4 (10.0)
Prophylaxis with acetylsalicilic acid, n (%) 29 (36.2) 10 (25.0) 19 (47.5) 0.062

The relationship between preeclampsia and treatment with metoprolol and acetylsalicylic acid

Variables Odds ratio 95% confidence interval p value
Treatment with metoprolol 0.0886 0.0171 to 0.4600 0.0039
Prophylaxis with acetylsalicylic acid 0.1456 0.0274 to 0.7736 0.0237
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