Critical Appraisal of Medical System Performance for STEMI Management – a Comprehensive Analysis of Time Efficiency

1. Nowbar AN, Gitto M, Howard JP, Francis DP, Al-Lamee R. Mortality From Ischemic Heart Disease. Circ Cardiovasc Qual Outcomes. 2019;12(6):e005375. doi: 10.1161/CIRCOUTCOMES.118.005375 NowbarAN GittoM HowardJP FrancisDP Al-LameeR Mortality From Ischemic Heart Disease Circ Cardiovasc Qual Outcomes 2019 12 6 e005375 10.1161/CIRCOUTCOMES.118.005375 Open DOISearch in Google Scholar

2. Ahuja KR, Saad AM, Nazir S, et al. Trends in Clinical Characteristics and Outcomes in ST-Elevation Myocardial Infarction Hospitalizations in the United States, 2002–2016. Curr Probl Cardiol. 2022;47(12):101005. doi: 10.1016/j.cpcardiol.2021.101005 AhujaKR SaadAM NazirS Trends in Clinical Characteristics and Outcomes in ST-Elevation Myocardial Infarction Hospitalizations in the United States, 2002–2016 Curr Probl Cardiol 2022 47 12 101005 10.1016/j.cpcardiol.2021.101005 Open DOISearch in Google Scholar

3. Pascual I, Hernandez-Vaquero D, Almendarez M, et al. Observed and Expected Survival in Men and Women After Suffering a STEMI. J Clin Med. 2020;9(4):1174. doi: 10.3390/jcm9041174. PascualI Hernandez-VaqueroD AlmendarezM Observed and Expected Survival in Men and Women After Suffering a STEMI J Clin Med 2020 9 4 1174 10.3390/jcm9041174 Open DOISearch in Google Scholar

4. Pedersen F, Butrymovich V, Kelbaek H, et al. Short- and long-term cause of death in patients treated with primary PCI for STEMI. J Am Coll Cardiol. 2014;64(20):2101–2108. doi: 10.1016/j.jacc.2014.08.037 PedersenF ButrymovichV KelbaekH Short- and long-term cause of death in patients treated with primary PCI for STEMI J Am Coll Cardiol 2014 64 20 2101 2108 10.1016/j.jacc.2014.08.037 Open DOISearch in Google Scholar

5. Park J, Choi KH, Lee JM, et al. Prognostic Implications of Door-to-Balloon Time and Onset-to-Door Time on Mortality in Patients With ST -Segment-Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention. J Am Heart Assoc. 2019;8(9):e012188. doi: 10.1161/JAHA.119.012188 ParkJ ChoiKH LeeJM Prognostic Implications of Door-to-Balloon Time and Onset-to-Door Time on Mortality in Patients With ST -Segment-Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention J Am Heart Assoc 2019 8 9 e012188 10.1161/JAHA.119.012188 Open DOISearch in Google Scholar

6. Nallamothu B, Fox KA, Kennelly BM, et al. Relationship of treatment delays and mortality in patients undergoing fibrinolysis and primary percutaneous coronary intervention. The Global Registry of Acute Coronary Events. Heart. 2007;93(12):1552–1555. doi: 10.1136/hrt.2006.112847 NallamothuB FoxKA KennellyBM Relationship of treatment delays and mortality in patients undergoing fibrinolysis and primary percutaneous coronary intervention. The Global Registry of Acute Coronary Events Heart 2007 93 12 1552 1555 10.1136/hrt.2006.112847 Open DOISearch in Google Scholar

7. Ghimire G, Gupta A, Hage FG. Guidelines in review: 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction. J Nucl Cardiol. 2014;21(1):190–191. doi: 10.1007/s12350-013-9808-x GhimireG GuptaA HageFG Guidelines in review: 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction J Nucl Cardiol 2014 21 1 190 191 10.1007/s12350-013-9808-x Open DOISearch in Google Scholar

8. Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Rev Esp Cardiol (Engl Ed). 2017;70(12):1082. doi: 10.1016/j.rec.2017.11.010 IbanezB JamesS AgewallS 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation Rev Esp Cardiol (Engl Ed) 2017 70 12 1082 10.1016/j.rec.2017.11.010 Open DOISearch in Google Scholar

9. Fordyce CB, Henry TD, Granger CB. Implementation of Regional ST-Segment Elevation Myocardial Infarction Systems of Care: Successes and Challenges. Interv Cardiol Clin. 2016;5(4):415–425. doi: 10.1016/j.iccl.2016.06.001 FordyceCB HenryTD GrangerCB Implementation of Regional ST-Segment Elevation Myocardial Infarction Systems of Care: Successes and Challenges Interv Cardiol Clin 2016 5 4 415 425 10.1016/j.iccl.2016.06.001 Open DOISearch in Google Scholar

10. Jollis JG, Al-Khalidi HR, Roettig ML, et al. Impact of Regionalization of ST-Segment-Elevation Myocardial Infarction Care on Treatment Times and Outcomes for Emergency Medical Services-Transported Patients Presenting to Hospitals With Percutaneous Coronary Intervention: Mission: Lifeline Accelerator-2. Circulation. 2018;137(4):376–387. doi: 10.1161/CIRCULATIONAHA.117.032446 JollisJG Al-KhalidiHR RoettigML Impact of Regionalization of ST-Segment-Elevation Myocardial Infarction Care on Treatment Times and Outcomes for Emergency Medical Services-Transported Patients Presenting to Hospitals With Percutaneous Coronary Intervention: Mission: Lifeline Accelerator-2 Circulation 2018 137 4 376 387 10.1161/CIRCULATIONAHA.117.032446 Open DOISearch in Google Scholar

11. Jollis JG, Al-Khalidi HR, Roettig ML, et al. Regional Systems of Care Demonstration Project: American Heart Association Mission: Lifeline STEMI Systems Accelerator. Circulation. 2016;134(5):365–374. doi: 10.1161/CIRCULATIONAHA.115.019474 JollisJG Al-KhalidiHR RoettigML Regional Systems of Care Demonstration Project: American Heart Association Mission: Lifeline STEMI Systems Accelerator Circulation 2016 134 5 365 374 10.1161/CIRCULATIONAHA.115.019474 Open DOISearch in Google Scholar

12. Tatu-Chitoiu G, Arafat R, Deleanu D, Vinereanu D, Udroiu C, Petris A. Impact of the Romanian national programme for interventional therapy in ST-elevation myocardial infarction. EuroIntervention. 2012;8 Suppl P:P126–132. doi: 10.4244/EIJV8SPA22 Tatu-ChitoiuG ArafatR DeleanuD VinereanuD UdroiuC PetrisA Impact of the Romanian national programme for interventional therapy in ST-elevation myocardial infarction EuroIntervention 2012 8 Suppl P P126 132 10.4244/EIJV8SPA22 Open DOISearch in Google Scholar

13. Thygesen K, Alpert JS, Jaffe AS, et al. Fourth Universal Definition of Myocardial Infarction (2018). Glob Heart. 2018;13(4):305–338. doi: 10.1016/j.gheart.2018.08.004 ThygesenK AlpertJS JaffeAS Fourth Universal Definition of Myocardial Infarction (2018) Glob Heart 2018 13 4 305 338 10.1016/j.gheart.2018.08.004 Open DOISearch in Google Scholar

14. Schulman S, Angeras U, Bergqvist D, et al. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients. J Thromb Haemost. 2010;8(1):202–204. doi: 10.1111/j.1538-7836.2009.03678.x SchulmanS AngerasU BergqvistD Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients J Thromb Haemost 2010 8 1 202 204 10.1111/j.1538-7836.2009.03678.x Open DOISearch in Google Scholar

15. Prasad A, Gersh BJ, Mehran R, et al. Effect of Ischemia Duration and Door-to-Balloon Time on Myocardial Perfusion in ST-Segment Elevation Myocardial Infarction: An Analysis From HORIZONS-AMI Trial (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction). JACC Cardiovasc Interv. 2015;8(15):1966–1974. doi: 10.1016/j.jcin.2015.08.031 PrasadA GershBJ MehranR Effect of Ischemia Duration and Door-to-Balloon Time on Myocardial Perfusion in ST-Segment Elevation Myocardial Infarction: An Analysis From HORIZONS-AMI Trial (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) JACC Cardiovasc Interv 2015 8 15 1966 1974 10.1016/j.jcin.2015.08.031 Open DOISearch in Google Scholar

16. Garcia-Dorado D, Theroux P, Elizaga J, Galinanes M, Solares J, Riesgo M, et al. Myocardial reperfusion in the pig heart model: infarct size and duration of coronary occlusion. Cardiovasc Res. 1987;21(7):537–544. doi: 10.1093/cvr/21.7.537 Garcia-DoradoD TherouxP ElizagaJ GalinanesM SolaresJ RiesgoM Myocardial reperfusion in the pig heart model: infarct size and duration of coronary occlusion Cardiovasc Res 1987 21 7 537 544 10.1093/cvr/21.7.537 Open DOISearch in Google Scholar

17. Reimer KA, Vander Heide RS, Richard VJ. Reperfusion in acute myocardial infarction: effect of timing and modulating factors in experimental models. Am J Cardiol. 1993;72(19):13G–21G. doi: 10.1016/0002-9149(93)90102-i ReimerKA Vander HeideRS RichardVJ Reperfusion in acute myocardial infarction: effect of timing and modulating factors in experimental models Am J Cardiol 1993 72 19 13G 21G 10.1016/0002-9149(93)90102-i Open DOISearch in Google Scholar

18. Sardar MR, Dawn Abbott J. Myocardial salvage and mortality in STEMI: A race against ischemic time. Catheter Cardiovasc Interv. 2016;87(7):1201–1202. doi: 10.1002/ccd.26599 SardarMR Dawn AbbottJ Myocardial salvage and mortality in STEMI: A race against ischemic time Catheter Cardiovasc Interv 2016 87 7 1201 1202 10.1002/ccd.26599 Open DOISearch in Google Scholar

19. Solhpour A, Chang KW, Arain SA, et al. Ischemic time is a better predictor than door-to-balloon time for mortality and infarct size in ST-elevation myocardial infarction. Catheter Cardiovasc Interv. 2016;87(7):1194–1200. doi: 10.1002/ccd.26230 SolhpourA ChangKW ArainSA Ischemic time is a better predictor than door-to-balloon time for mortality and infarct size in ST-elevation myocardial infarction Catheter Cardiovasc Interv 2016 87 7 1194 1200 10.1002/ccd.26230 Open DOISearch in Google Scholar

20. Chandrasekhar J, Marley P, Allada C, et al. Symptom-to-Balloon Time is a Strong Predictor of Adverse Events Following Primary Percutaneous Coronary Intervention: Results From the Australian Capital Territory PCI Registry. Heart Lung Circ. 2017;26(1):41–48. doi: 10.1016/j.hlc.2016.05.114 ChandrasekharJ MarleyP AlladaC Symptom-to-Balloon Time is a Strong Predictor of Adverse Events Following Primary Percutaneous Coronary Intervention: Results From the Australian Capital Territory PCI Registry Heart Lung Circ 2017 26 1 41 48 10.1016/j.hlc.2016.05.114 Open DOISearch in Google Scholar

21. Kim HK, Jeong MH, Ahn Y, et al. Relationship between time to treatment and mortality among patients undergoing primary percutaneous coronary intervention according to Korea Acute Myocardial Infarction Registry. J Cardiol. 2017;69(1):377–382. doi: 10.1016/j.jjcc.2016.09.002 KimHK JeongMH AhnY Relationship between time to treatment and mortality among patients undergoing primary percutaneous coronary intervention according to Korea Acute Myocardial Infarction Registry J Cardiol 2017 69 1 377 382 10.1016/j.jjcc.2016.09.002 Open DOISearch in Google Scholar

22. Khowaja S, Ahmed S, Kumar R, et al. Time to think beyond door to balloon time: significance of total ischemic time in STEMI. Egypt Heart J. 2021;73(1):95. doi: 10.1186/s43044-021-00221-1 KhowajaS AhmedS KumarR Time to think beyond door to balloon time: significance of total ischemic time in STEMI Egypt Heart J 2021 73 1 95 10.1186/s43044-021-00221-1 Open DOISearch in Google Scholar

23. Doddipalli SR, Rajasekhar D, Vanajakshamma V, Sreedhar Naik K. Determinants of total ischemic time in primary percutaneous coronary interventions: A prospective analysis. Indian Heart J. 2018;70(Suppl 3):S275–S279. doi: 10.1016/j.ihj.2018.05.005 DoddipalliSR RajasekharD VanajakshammaV Sreedhar NaikK Determinants of total ischemic time in primary percutaneous coronary interventions: A prospective analysis Indian Heart J 2018 70 Suppl 3 S275 S279 10.1016/j.ihj.2018.05.005 Open DOISearch in Google Scholar

24. Hedges JR, Feldman HA, Bittner V, et al. Impact of community intervention to reduce patient delay time on use of reperfusion therapy for acute myocardial infarction: rapid early action for coronary treatment (REACT) trial. REACT Study Group. Acad Emerg Med. 2000;7(8):862–872. doi: 10.1111/j.1553-2712.2000.tb02063.x HedgesJR FeldmanHA BittnerV Impact of community intervention to reduce patient delay time on use of reperfusion therapy for acute myocardial infarction: rapid early action for coronary treatment (REACT) trial. REACT Study Group Acad Emerg Med 2000 7 8 862 872 10.1111/j.1553-2712.2000.tb02063.x Open DOISearch in Google Scholar

25. Blohm MB, Hartford M, Karlson BW, Luepker RV, Herlitz J. An evaluation of the results of media and educational campaigns designed to shorten the time taken by patients with acute myocardial infarction to decide to go to hospital. Heart. 1996;76(5):430–434. doi: 10.1136/hrt.76.5.430 BlohmMB HartfordM KarlsonBW LuepkerRV HerlitzJ An evaluation of the results of media and educational campaigns designed to shorten the time taken by patients with acute myocardial infarction to decide to go to hospital Heart 1996 76 5 430 434 10.1136/hrt.76.5.430 Open DOISearch in Google Scholar

26. Regueiro A, Rosas A, Kaifoszova Z, et al. Impact of the “ACT NOW. SAVE A LIFE” public awareness campaign on the performance of a European STEMI network. Int J Cardiol. 2015;197:110–112. doi: 10.1016/j.ijcard.2015.06.040 RegueiroA RosasA KaifoszovaZ Impact of the “ACT NOW. SAVE A LIFE” public awareness campaign on the performance of a European STEMI network Int J Cardiol 2015 197 110 112 10.1016/j.ijcard.2015.06.040 Open DOISearch in Google Scholar

27. Terkelsen CJ, Sorensen JT, Maeng M, et al. System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention. JAMA. 2010;304(7):763–771. doi: 10.1001/jama.2010.1139 TerkelsenCJ SorensenJT MaengM System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention JAMA 2010 304 7 763 771 10.1001/jama.2010.1139 Open DOISearch in Google Scholar

28. Chakrabarti A, Krumholz HM, Wang Y, Rumsfeld JS, Nallamothu BK, National Cardiovascular Data R. Time-to-reperfusion in patients undergoing interhospital transfer for primary percutaneous coronary intervention in the U.S: an analysis of 2005 and 2006 data from the National Cardiovascular Data Registry. JACC. 2008;51(25):2442–2443. doi: 10.1016/j.jacc.2008.02.071 ChakrabartiA KrumholzHM WangY RumsfeldJS NallamothuBK National Cardiovascular Data R Time-to-reperfusion in patients undergoing interhospital transfer for primary percutaneous coronary intervention in the U.S: an analysis of 2005 and 2006 data from the National Cardiovascular Data Registry JACC 2008 51 25 2442 2443 10.1016/j.jacc.2008.02.071 Open DOISearch in Google Scholar

29. Nallamothu BK, Bates ER, Herrin J, et al. Times to treatment in transfer patients undergoing primary percutaneous coronary intervention in the United States: National Registry of Myocardial Infarction (NRMI)-3/4 analysis. Circulation. 2005;111(6):761–767. doi: 10.1161/01.CIR.0000155258.44268.F8 NallamothuBK BatesER HerrinJ Times to treatment in transfer patients undergoing primary percutaneous coronary intervention in the United States: National Registry of Myocardial Infarction (NRMI)-3/4 analysis Circulation 2005 111 6 761 767 10.1161/01.CIR.0000155258.44268.F8 Open DOISearch in Google Scholar

30. Ikemura N, Kohsaka S, Ueda I, Maekawa Y, Fukuda K. Factors associated with delay in door-to-balloon time in Japan: a report from contemporary multicenter PCI registry. JACC. 2016;67(S13):652. doi: 10.1016/S0735-1097(16)30653-2 IkemuraN KohsakaS UedaI MaekawaY FukudaK Factors associated with delay in door-to-balloon time in Japan: a report from contemporary multicenter PCI registry JACC 2016 67 S13 652 10.1016/S0735-1097(16)30653-2 Open DOISearch in Google Scholar

31. Bagai A, Jollis JG, Dauerman HL, et al. Emergency department bypass for ST-Segment-elevation myocardial infarction patients identified with a prehospital electrocardiogram: a report from the American Heart Association Mission: Lifeline program. Circulation. 2013;128(4):352–359. doi: 10.1161/CIRCULATIONAHA.113.002339 BagaiA JollisJG DauermanHL Emergency department bypass for ST-Segment-elevation myocardial infarction patients identified with a prehospital electrocardiogram: a report from the American Heart Association Mission: Lifeline program Circulation 2013 128 4 352 359 10.1161/CIRCULATIONAHA.113.002339 Open DOISearch in Google Scholar

32. Pinto DS, Frederick PD, Chakrabarti AK, et al. Benefit of transferring ST-segment-elevation myocardial infarction patients for percutaneous coronary intervention compared with administration of onsite fibrinolytic declines as delays increase. Circulation. 2011;124(23):2512–2521. doi: 10.1161/CIRCULATIONAHA.111.018549 PintoDS FrederickPD ChakrabartiAK Benefit of transferring ST-segment-elevation myocardial infarction patients for percutaneous coronary intervention compared with administration of onsite fibrinolytic declines as delays increase Circulation 2011 124 23 2512 2521 10.1161/CIRCULATIONAHA.111.018549 Open DOISearch in Google Scholar

33. Boersma E. Primary Coronary Angioplasty vs. Thrombolysis G. Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J. 2006;27(7):779–788. doi: 10.1093/eurheartj/ehi810 BoersmaE Primary Coronary Angioplasty vs. Thrombolysis G. Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients Eur Heart J 2006 27 7 779 788 10.1093/eurheartj/ehi810 Open DOISearch in Google Scholar

34. Larson DM, Duval S, Sharkey SW, et al. Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to long-distance transfers. Eur Heart J. 2012;33(10):1232–1240. doi: 10.1093/eurheartj/ehr403 LarsonDM DuvalS SharkeySW Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to long-distance transfers Eur Heart J 2012 33 10 1232 1240 10.1093/eurheartj/ehr403 Open DOISearch in Google Scholar

35. Larson DM, McKavanagh P, Henry TD, Cantor WJ. Reperfusion Options for ST Elevation Myocardial Infarction Patients with Expected Delays to Percutaneous Coronary Intervention. Interv Cardiol Clin. 2016;5(4):439–450. doi: 10.1016/j.iccl.2016.06.004 LarsonDM McKavanaghP HenryTD CantorWJ Reperfusion Options for ST Elevation Myocardial Infarction Patients with Expected Delays to Percutaneous Coronary Intervention Interv Cardiol Clin 2016 5 4 439 450 10.1016/j.iccl.2016.06.004 Open DOISearch in Google Scholar