<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3><p>Critical illness polyneuropathy (CIP) is a complex disease commonly occurring in septic patients which indicates a worse prognosis. Herein, we investigated the characteristics of cerebrospinal fluid (CSF) in septic patients with CIP.</p></sec>
<sec><h3>Methods</h3><p>This retrospective study was conducted between Match 1, 2018, and July 1, 2022. Patients with sepsis who underwent a CSF examination and nerve electrophysiology were included. The levels of protein, glucose, lipopolysaccharide, white blood cell (WBC), interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF) α in CSF were measured. The fungi and bacteria in CSF were also assessed.</p></sec>
<sec><h3>Results</h3><p>Among the 175 septic patients, 116 (66.3%) patients were diagnosed with CIP. 28-day Mortality in CIP patients was higher than that in non-CIP patients (25.0% vs. 10.2%, P = 0.02) which was confirmed by survival analysis. The results of propensity score matching analysis (PSMA) indicated a significant difference in the level of protein, WBC, IL-1, IL-6, IL-8, and TNFα present in the CSF between CIP patients and non-CIP patients. The results of the receiver operating characteristic (ROC) analysis showed that IL-1, WBC, TNFα, and their combined indicator had a good diagnostic value with an AUC > 0.8.</p></sec>
<sec><h3>Conclusion</h3><p>The increase in the levels of WBC, IL-1, and TNFα in CSF might be an indicator of CIP in septic patients.</p></sec>
</abstract>

BackgroundCritical illness polyneuropathy (CIP) is a complex disease commonly occurring in septic patients which indicates a worse prognosis. Herein, we investigated the characteristics of cerebrospinal fluid (CSF) in septic patients with CIP.
MethodsThis retrospective study was conducted between Match 1, 2018, and July 1, 2022. Patients with sepsis who underwent a CSF examination and nerve electrophysiology were included. The levels of protein, glucose, lipopolysaccharide, white blood cell (WBC), interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF) α in CSF were measured. The fungi and bacteria in CSF were also assessed.
ResultsAmong the 175 septic patients, 116 (66.3%) patients were diagnosed with CIP. 28-day Mortality in CIP patients was higher than that in non-CIP patients (25.0% vs. 10.2%, P = 0.02) which was confirmed by survival analysis. The results of propensity score matching analysis (PSMA) indicated a significant difference in the level of protein, WBC, IL-1, IL-6, IL-8, and TNFα present in the CSF between CIP patients and non-CIP patients. The results of the receiver operating characteristic (ROC) analysis showed that IL-1, WBC, TNFα, and their combined indicator had a good diagnostic value with an AUC > 0.8.
ConclusionThe increase in the levels of WBC, IL-1, and TNFα in CSF might be an indicator of CIP in septic patients.

Characteristics of the Cerebrospinal Fluid in Septic Patients with Critical Illness Polyneuropathy - A Retrospective Cohort Study

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

BackgroundCritical illness polyneuropathy (CIP) is a complex disease commonly occurring in septic patients which indicates a worse prognosis. Herein, we...

Characteristics of the Cerebrospinal Fluid in Septic Patients with Critical Illness Polyneuropathy - A Retrospective Cohort Study

Article Category: Review

Published Online: Apr 30, 2024

Page range: 130 - 138

Received: Feb 13, 2024

Accepted: Apr 13, 2024

DOI: https://doi.org/10.2478/jccm-2024-0018

Keywords
acute physiology and chronic health evaluation II, cerebrospinal fluid, critical illness polyneuropathy, sepsis, sequential organ failure assessment score

© 2024 Yanyang Zhang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Characteristics of the Cerebrospinal Fluid in Septic Patients with Critical Illness Polyneuropathy - A Retrospective Cohort Study

Article Category: Review

Published Online: Apr 30, 2024

Page range: 130 - 138

Received: Feb 13, 2024

Accepted: Apr 13, 2024

DOI: https://doi.org/10.2478/jccm-2024-0018

Keywordsacute physiology and chronic health evaluation II, cerebrospinal fluid, critical illness polyneuropathy, sepsis, sequential organ failure assessment score

© 2024 Yanyang Zhang et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
acute physiology and chronic health evaluation II, cerebrospinal fluid, critical illness polyneuropathy, sepsis, sequential organ failure assessment score