<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jccm-2022-0015_s_006">
<h3>Introduction</h3>
<p>The use of invasive mechanical ventilation (IMV) in COVID-19 represents in an incremental burden to healthcare systems.</p>
</sec>
<sec id="j_jccm-2022-0015_s_007">
<h3>Aim of the study</h3>
<p>We aimed to characterize patients hospitalized for COVID-19 who received IMV and identify risk factors for mortality in this population.</p>
</sec>
<sec id="j_jccm-2022-0015_s_008">
<h3>Material and Methods</h3>
<p>A retrospective cohort study including consecutive adult patients admitted to a private network in Brazil who received IMV from March to October, 2020. A bidirectional stepwise logistic regression analysis was used to determine the risk factors for mortality.</p>
</sec>
<sec id="j_jccm-2022-0015_s_009">
<h3>Results</h3>
<p>We included 215 patients, of which 96 died and 119 were discharged from ICU. The mean age was 62.7 ± 15.4 years and the most important comorbidities were hypertension (62.8%), obesity (50.7%) and diabetes (40%). Non-survivors had lower body mass index (BMI) (28.3 [25.5; 31.6] vs. 31.2 [28.3; 35], p&lt;0.001, and a shorter duration from symptom onset to intubation (8.5 [6.0; 12] days vs. 10 [8.0; 12.5] days, p = 0.005). Multivariable regression analysis showed that the risk factors for mortality were age (OR: 1.07, 95% CI: 1.03 to 1.1, p &lt; 0.001), creatinine level at the intubation date (OR: 3.28, 95% CI: 1.47 to 7.33, p = 0.004), BMI (OR: 0.91, 95% CI: 0.84 to 0.99, p = 0.033), lowest PF ratio within 48 hours post-intubation (OR: 0.988, 95% CI: 0.979 to 0.997, p = 0.011), barotrauma (OR: 5.18, 95% CI: 1.14 to 23.65, p = 0.034) and duration from symptom onset to intubation (OR: 0.76, 95% CI: 0.76 to 0.95, p = 0.006).</p>
</sec>

<sec id="j_jccm-2022-0015_s_010">
<h3>Conclusion</h3>
<p>In our retrospective cohort we identified the main risk factors for mortality in COVID-19 patients receiving IMV: age, creatinine at the day of intubation, BMI, lowest PF ratio 48-hours post-intubation, barotrauma and duration from symptom onset to intubation.</p>
</sec>
</abstract>

Introduction
The use of invasive mechanical ventilation (IMV) in COVID-19 represents in an incremental burden to healthcare systems.


Aim of the study
We aimed to characterize patients hospitalized for COVID-19 who received IMV and identify risk factors for mortality in this population.


Material and Methods
A retrospective cohort study including consecutive adult patients admitted to a private network in Brazil who received IMV from March to October, 2020. A bidirectional stepwise logistic regression analysis was used to determine the risk factors for mortality.


Results
We included 215 patients, of which 96 died and 119 were discharged from ICU. The mean age was 62.7 ± 15.4 years and the most important comorbidities were hypertension (62.8%), obesity (50.7%) and diabetes (40%). Non-survivors had lower body mass index (BMI) (28.3 [25.5; 31.6] vs. 31.2 [28.3; 35], p<0.001, and a shorter duration from symptom onset to intubation (8.5 [6.0; 12] days vs. 10 [8.0; 12.5] days, p = 0.005). Multivariable regression analysis showed that the risk factors for mortality were age (OR: 1.07, 95% CI: 1.03 to 1.1, p < 0.001), creatinine level at the intubation date (OR: 3.28, 95% CI: 1.47 to 7.33, p = 0.004), BMI (OR: 0.91, 95% CI: 0.84 to 0.99, p = 0.033), lowest PF ratio within 48 hours post-intubation (OR: 0.988, 95% CI: 0.979 to 0.997, p = 0.011), barotrauma (OR: 5.18, 95% CI: 1.14 to 23.65, p = 0.034) and duration from symptom onset to intubation (OR: 0.76, 95% CI: 0.76 to 0.95, p = 0.006).



Conclusion
In our retrospective cohort we identified the main risk factors for mortality in COVID-19 patients receiving IMV: age, creatinine at the day of intubation, BMI, lowest PF ratio 48-hours post-intubation, barotrauma and duration from symptom onset to intubation.

Characteristics and risk factors for mortality in critically ill patients with COVID-19 receiving invasive mechanical ventilation: the experience of a private network in Sao Paulo, Brazil

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

Introduction
The use of invasive mechanical ventilation (IMV) in COVID-19 represents in an incremental burden to healthcare systems.


Aim of the study
We...

Characteristics and risk factors for mortality in critically ill patients with COVID-19 receiving invasive mechanical ventilation: the experience of a private network in Sao Paulo, Brazil

Article Category: Research Article

Published Online: Aug 12, 2022

Page range: 165 - 175

Received: Dec 12, 2021

Accepted: Jun 12, 2022

DOI: https://doi.org/10.2478/jccm-2022-0015

Keywords
coronavirus, COVID-19, mortality, mechanical ventilation, body mass index, barotrauma

© 2022 Eduardo Atsushi Osawa, Alexandre Toledo Maciel, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Characteristics and risk factors for mortality in critically ill patients with COVID-19 receiving invasive mechanical ventilation: the experience of a private network in Sao Paulo, Brazil

Article Category: Research Article

Published Online: Aug 12, 2022

Page range: 165 - 175

Received: Dec 12, 2021

Accepted: Jun 12, 2022

DOI: https://doi.org/10.2478/jccm-2022-0015

Keywordscoronavirus, COVID-19, mortality, mechanical ventilation, body mass index, barotrauma

© 2022 Eduardo Atsushi Osawa, Alexandre Toledo Maciel, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
coronavirus, COVID-19, mortality, mechanical ventilation, body mass index, barotrauma