<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jccm-2021-0025_s_006">
<h3>Introduction</h3>
<p>Rhabdomyolysis, which resulted from the rapid breakdown of damaged skeletal muscle, potentially leads to acute kidney injury.</p>
</sec>
<sec id="j_jccm-2021-0025_s_007">
<h3>Aim</h3>
<p>To determine the incidence and associated risk of kidney injury following rhabdomyolysis in critically ill patients.</p>
</sec>
<sec id="j_jccm-2021-0025_s_008">
<h3>Methods</h3>
<p>All critically ill patients admitted from January 2016 to December 2017 were screened. A creatinine kinase level of > 5 times the upper limit of normal (> 1000 U/L) was defined as rhabdomyolysis, and kidney injury was determined based on the Kidney Disease Improving Global Outcome (KDIGO) score. In addition, trauma, prolonged surgery, sepsis, antipsychotic drugs, hyperthermia were included as risk factors for kidney injury.</p>
</sec>
<sec id="j_jccm-2021-0025_s_009">
<h3>Results</h3>
<p>Out of 1620 admissions, 149 (9.2%) were identified as having rhabdomyolysis and 54 (36.2%) developed kidney injury. Acute kidney injury, by and large, was related to rhabdomyolysis followed a prolonged surgery (18.7%), sepsis (50.0%) or trauma (31.5%). The reduction in the creatinine kinase levels following hydration treatment was statistically significant in the non- kidney injury group (Z= -3.948, p&lt;0.05) compared to the kidney injury group (Z= -0.623, p=0.534). Significantly, odds of developing acute kidney injury were 1.040 (p&lt;0.001) for mean BW >50kg, 1.372(p&lt;0.001) for SOFA Score >2, 5.333 (p&lt;0.001) for sepsis and the multivariate regression analysis showed that SOFA scores >2 (p&lt;0.001), BW >50kg (p=0.016) and sepsis (p&lt;0.05) were independent risk factors. The overall mortality due to rhabdomyolysis was 15.4% (23/149), with significantly higher incidences of mortality in the kidney injury group (35.2%) vs the non- kidney injury (3.5%) [ p&lt;0.001].</p>
</sec>
<sec id="j_jccm-2021-0025_s_010">
<h3>Conclusions</h3>
<p>One-third of rhabdomyolysis patients developed acute kidney injury with a significantly high mortality rate. Sepsis was a prominent cause of acute kidney injury. Both sepsis and a SOFA score >2 were significant independent risk factors.</p>
</sec>
</abstract>

Introduction
Rhabdomyolysis, which resulted from the rapid breakdown of damaged skeletal muscle, potentially leads to acute kidney injury.


Aim
To determine the incidence and associated risk of kidney injury following rhabdomyolysis in critically ill patients.


Methods
All critically ill patients admitted from January 2016 to December 2017 were screened. A creatinine kinase level of > 5 times the upper limit of normal (> 1000 U/L) was defined as rhabdomyolysis, and kidney injury was determined based on the Kidney Disease Improving Global Outcome (KDIGO) score. In addition, trauma, prolonged surgery, sepsis, antipsychotic drugs, hyperthermia were included as risk factors for kidney injury.


Results
Out of 1620 admissions, 149 (9.2%) were identified as having rhabdomyolysis and 54 (36.2%) developed kidney injury. Acute kidney injury, by and large, was related to rhabdomyolysis followed a prolonged surgery (18.7%), sepsis (50.0%) or trauma (31.5%). The reduction in the creatinine kinase levels following hydration treatment was statistically significant in the non- kidney injury group (Z= -3.948, p<0.05) compared to the kidney injury group (Z= -0.623, p=0.534). Significantly, odds of developing acute kidney injury were 1.040 (p<0.001) for mean BW >50kg, 1.372(p<0.001) for SOFA Score >2, 5.333 (p<0.001) for sepsis and the multivariate regression analysis showed that SOFA scores >2 (p<0.001), BW >50kg (p=0.016) and sepsis (p<0.05) were independent risk factors. The overall mortality due to rhabdomyolysis was 15.4% (23/149), with significantly higher incidences of mortality in the kidney injury group (35.2%) vs the non- kidney injury (3.5%) [ p<0.001].


Conclusions
One-third of rhabdomyolysis patients developed acute kidney injury with a significantly high mortality rate. Sepsis was a prominent cause of acute kidney injury. Both sepsis and a SOFA score >2 were significant independent risk factors.

Acute Kidney Injury Following Rhabdomyolysis in Critically Ill Patients

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Acute Kidney Injury Following Rhabdomyolysis in Critically Ill Patients"}

Introduction
Rhabdomyolysis, which resulted from the rapid breakdown of damaged skeletal muscle, potentially leads to acute kidney injury.


Aim
To determine the incidence and associated risk of kidney injury following rhabdomyolysis in critically ill patients.


Methods
All critically ill patients admitted from January 2016 to December 2017 were screened. A creatinine kinase level of > 5 times the upper limit of normal (> 1000 U/L) was defined as rhabdomyolysis, and kidney injury was determined based on the Kidney Disease Improving Global Outcome (KDIGO) score. In addition, trauma, prolonged surgery, sepsis, antipsychotic drugs, hyperthermia were included as risk factors for kidney injury.


Results
Out of 1620 admissions, 149 (9.2%) were identified as having rhabdomyolysis and 54 (36.2%) developed kidney injury. Acute kidney injury, by and large, was related to rhabdomyolysis followed a prolonged surgery (18.7%), sepsis (50.0%) or trauma (31.5%). The reduction in the creatinine kinase levels following hydration treatment was statistically significant in the non- kidney injury group (Z= -3.948, p50kg, 1.372(p2, 5.333 (p2 (p50kg (p=0.016) and sepsis (p2 were significant independent risk factors.

Introduction
Rhabdomyolysis, which resulted from the rapid breakdown of damaged skeletal muscle, potentially leads to acute kidney injury.


Aim
To determine...

Acute Kidney Injury Following Rhabdomyolysis in Critically Ill Patients

Article Category: Research article

Published Online: Nov 06, 2021

Page range: 267 - 271

Received: Mar 30, 2021

Accepted: Jun 30, 2021

DOI: https://doi.org/10.2478/jccm-2021-0025

Keywords
acute kidney injury, creatinine, critically ill, dialysis, rhabdomyolysis

© 2021 Alvin Saverymuthu, Rufinah Teo, Jaafar Md Zain, Saw Kian Cheah, Aliza Mohamad Yusof, Raha Abdul Rahman, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Acute Kidney Injury Following Rhabdomyolysis in Critically Ill Patients

Article Category: Research article

Published Online: Nov 06, 2021

Page range: 267 - 271

Received: Mar 30, 2021

Accepted: Jun 30, 2021

DOI: https://doi.org/10.2478/jccm-2021-0025

Keywordsacute kidney injury, creatinine, critically ill, dialysis, rhabdomyolysis

© 2021 Alvin Saverymuthu, Rufinah Teo, Jaafar Md Zain, Saw Kian Cheah, Aliza Mohamad Yusof, Raha Abdul Rahman, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
acute kidney injury, creatinine, critically ill, dialysis, rhabdomyolysis