<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jccm-2021-0021_s_006">
<h3>Introduction</h3>
<p>The World Health Organization (WHO) identified a novel coronavirus, originating in Wuhan, China, in December 2019, as a pneumonia causing pathogen. Epidemiological data in Romania show more than 450.000 confirmed patients, with a constant number of approximately 10% admission in intensive care unit.</p></sec>
<sec id="j_jccm-2021-0021_s_007">
<h3>Method</h3>
<p>A retrospective, observational study was conducted from 1st March to 30th October 2020, comprising 657 patients, confirmed as having COVID-19, and who had been admitted to the intensive care unit of the Mures County Clinical Hospital, Tîrgu Mures, Romania, which had been designated as a support hospital during the pandemic. Patients who presented at admission or developed abnormal liver function tests in the first seven days of admission, were included in the study; patients with pre-existing liver disease, were excluded.</p></sec>
<sec id="j_jccm-2021-0021_s_008">
<h3>Results</h3>
<p>The mean (SD) age of patients included in the study was 59.41 (14.66) years with a male: female ratio of 1.51:1. Survivor status, defined as patients discharged from the intensive care unit, was significantly associated with parameters such as age, leukocyte count, albumin level, glycaemia level (p&lt;0.05 for all parameters.)</p></sec>
<sec id="j_jccm-2021-0021_s_009">
<h3>Conclusions</h3>
<p>Liver injury expressed through liver function tests cannot solely constitute a prognostic factor for COVID-19 patients, but its presence in critically ill patients should be further investigated and included in future guideline protocols.</p></sec></abstract>

Introduction
The World Health Organization (WHO) identified a novel coronavirus, originating in Wuhan, China, in December 2019, as a pneumonia causing pathogen. Epidemiological data in Romania show more than 450.000 confirmed patients, with a constant number of approximately 10% admission in intensive care unit.

Method
A retrospective, observational study was conducted from 1st March to 30th October 2020, comprising 657 patients, confirmed as having COVID-19, and who had been admitted to the intensive care unit of the Mures County Clinical Hospital, Tîrgu Mures, Romania, which had been designated as a support hospital during the pandemic. Patients who presented at admission or developed abnormal liver function tests in the first seven days of admission, were included in the study; patients with pre-existing liver disease, were excluded.

Results
The mean (SD) age of patients included in the study was 59.41 (14.66) years with a male: female ratio of 1.51:1. Survivor status, defined as patients discharged from the intensive care unit, was significantly associated with parameters such as age, leukocyte count, albumin level, glycaemia level (p<0.05 for all parameters.)

Conclusions
Liver injury expressed through liver function tests cannot solely constitute a prognostic factor for COVID-19 patients, but its presence in critically ill patients should be further investigated and included in future guideline protocols.

Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

Introduction
The World Health Organization (WHO) identified a novel coronavirus, originating in Wuhan, China, in December 2019, as a pneumonia causing...

Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak

Article Category: Research Article

Published Online: Aug 05, 2021

Page range: 211 - 216

Received: Nov 30, 2020

Accepted: Jun 27, 2021

DOI: https://doi.org/10.2478/jccm-2021-0021

Keywords
COVID-19, liver injury, SARS-COV2, pandemic outbreak

© 2021 Adina Roman, Septimiu Moldovan, Ario Santini, Mircea Stoian, Daniela Dobru, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak

Article Category: Research Article

Published Online: Aug 05, 2021

Page range: 211 - 216

Received: Nov 30, 2020

Accepted: Jun 27, 2021

DOI: https://doi.org/10.2478/jccm-2021-0021

KeywordsCOVID-19, liver injury, SARS-COV2, pandemic outbreak

© 2021 Adina Roman, Septimiu Moldovan, Ario Santini, Mircea Stoian, Daniela Dobru, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
COVID-19, liver injury, SARS-COV2, pandemic outbreak