<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_jccm-2020-0038_s_004_w2aab3b7c34b1b6b1aab1c16b1Aa"><h3>Objective</h3><p>A rare variant Miller Fisher Syndrome overlap with Guillain Barre Syndrome is described in an adult patient with SARS-COV-2 infection.</p></sec><sec id="j_jccm-2020-0038_s_005_w2aab3b7c34b1b6b1aab1c16b2Aa"><h3>Case Presentation</h3><p>The clinical course of a 45-year-old immunosuppressed man is summarized as a patient who developed ataxia, ophthalmoplegia, and areflexia after upper respiratory infection symptoms began. A nasopharyngeal swab was positive for COVID-19 polymerase chain reaction. He progressed to acute hypoxemic and hypercapnic respiratory failure requiring intubation and rapidly developed tetraparesis. Magnetic resonance imaging of the spine was consistent with Guillain Barre Syndrome. However, the clinical symptoms, along with positive anti-GQ1B antibodies, were consistent with Miller Fisher Syndrome and Guillain Barre Syndrome overlap. The patient required tracheostomy and had limited improvement in his significant neurological symptoms after several months.</p></sec><sec id="j_jccm-2020-0038_s_006_w2aab3b7c34b1b6b1aab1c16b3Aa"><h3>Conclusions</h3><p>The case demonstrates the severe neurological implications, prolonged recovery and implications in the concomitant respiratory failure of COVID-19 patients with neurological symptoms on the spectrum of disorders of Guillain Barre Syndrome.</p></sec></abstract>

ObjectiveA rare variant Miller Fisher Syndrome overlap with Guillain Barre Syndrome is described in an adult patient with SARS-COV-2 infection.Case PresentationThe clinical course of a 45-year-old immunosuppressed man is summarized as a patient who developed ataxia, ophthalmoplegia, and areflexia after upper respiratory infection symptoms began. A nasopharyngeal swab was positive for COVID-19 polymerase chain reaction. He progressed to acute hypoxemic and hypercapnic respiratory failure requiring intubation and rapidly developed tetraparesis. Magnetic resonance imaging of the spine was consistent with Guillain Barre Syndrome. However, the clinical symptoms, along with positive anti-GQ1B antibodies, were consistent with Miller Fisher Syndrome and Guillain Barre Syndrome overlap. The patient required tracheostomy and had limited improvement in his significant neurological symptoms after several months.ConclusionsThe case demonstrates the severe neurological implications, prolonged recovery and implications in the concomitant respiratory failure of COVID-19 patients with neurological symptoms on the spectrum of disorders of Guillain Barre Syndrome.

Atypical Variant of Guillain Barre Syndrome in a Patient with COVID-19

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Atypical Variant of Guillain Barre Syndrome in a Patient with COVID-19"}

ObjectiveA rare variant Miller Fisher Syndrome overlap with Guillain Barre Syndrome is described in an adult patient with SARS-COV-2 infection.Case...

Atypical Variant of Guillain Barre Syndrome in a Patient with COVID-19

Article Category: Case Report

Published Online: Nov 07, 2020

Page range: 231 - 236

Received: Jun 29, 2020

Accepted: Oct 20, 2020

DOI: https://doi.org/10.2478/jccm-2020-0038

Keywords
hypoxemic and hypercapnic respiratory failure, COVID-19, SARS-CoV-2, Guillain Barre Syndrome, Miller Fisher Syndrome

© 2020 Megan M. Lowery, Muhammad Taimur Malik, Joseph Seemiller, Cynthia S. Tsai, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

Fig. 2

Atypical Variant of Guillain Barre Syndrome in a Patient with COVID-19

Article Category: Case Report

Published Online: Nov 07, 2020

Page range: 231 - 236

Received: Jun 29, 2020

Accepted: Oct 20, 2020

DOI: https://doi.org/10.2478/jccm-2020-0038

Keywordshypoxemic and hypercapnic respiratory failure, COVID-19, SARS-CoV-2, Guillain Barre Syndrome, Miller Fisher Syndrome

© 2020 Megan M. Lowery, Muhammad Taimur Malik, Joseph Seemiller, Cynthia S. Tsai, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

Fig. 2

Keywords
hypoxemic and hypercapnic respiratory failure, COVID-19, SARS-CoV-2, Guillain Barre Syndrome, Miller Fisher Syndrome