This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
Guth PH. Gastric blood flow in restraint stress. Dig Dis Sci. 1972;17: 807–13.GuthPHGastric blood flow in restraint stressDig Dis Sci1972178071310.1007/BF02231152Search in Google Scholar
Abdel-Salam OM, El-Batran S. Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. Pharmacology. 2005;75:122-32Abdel-SalamOMEl-BatranSPharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodentsPharmacology2005751223210.1159/000088211Search in Google Scholar
Castagliuolo I, Lamont J.T, Qi B. Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells. Am J Physiol. 1996;271:884-92CastagliuoloILamontJ.TQiBAcute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cellsAm J Physiol19962718849210.1152/ajpgi.1996.271.5.G884Search in Google Scholar
Sutanto W, de Kloet ER. The use of various animal models in the study of stress and stress-related phenomena. Lab Anim. 1994;28:293-306SutantoWde KloetERThe use of various animal models in the study of stress and stress-related phenomenaLab Anim19942829330610.1258/002367794780745092Search in Google Scholar
Takeuchi K, Amagase K. Roles of Cyclooxygenase, Prostaglandin E2 and EP Receptors in Mucosal Protection and Ulcer Healing in the Gastrointestinal Tract.Curr Pharm Des. 2018;24:2002-11.TakeuchiKAmagaseKRoles of Cyclooxygenase, Prostaglandin E2 and EP Receptors in Mucosal Protection and Ulcer Healing in the Gastrointestinal TractCurr Pharm Des20182420021110.2174/1381612824666180629111227Search in Google Scholar
Amagase K, Izumi N, Takahira Y, Wada T, Takeuchi K. Importance of cyclooxygenase-1/prostacyclin in modulating gastric mucosal integrity under stress conditions. J Gastroenterol Hepatol. 2014;29 Suppl 4:3-10.AmagaseKIzumiNTakahiraYWadaTTakeuchiKImportance of cyclooxygenase-1/prostacyclin in modulating gastric mucosal integrity under stress conditionsJ Gastroenterol Hepatol201429 Suppl431010.1111/jgh.12767Search in Google Scholar
Takeuchi K, Kato S, Ogawa Y, Kanatsu K, Umeda M. Role of endogenous prostacyclin in gastric ulcerogenic and healing responses—a study using IP-receptor knockout mice. J Physiol. 2001;95:75–80.TakeuchiKKatoSOgawaYKanatsuKUmedaMRole of endogenous prostacyclin in gastric ulcerogenic and healing responses—a study using IP-receptor knockout miceJ Physiol200195758010.1016/S0928-4257(01)00011-0Search in Google Scholar
Hayase M, Takeuchi K. Gastric acid secretion and lesion formation in rats under water-immersion stress. Dig Dis Sci.1986;31:166–71.HayaseMTakeuchiKGastric acid secretion and lesion formation in rats under water-immersion stressDig Dis Sci1986311667110.1007/BF01300703Search in Google Scholar
Kitagawa H, Fujiwara M, Osumi Y. Effects of water-immersion stress on gastric secretion and mucosal blood flow in rats. Gastroenterol.1979;77:298–302.KitagawaHFujiwaraMOsumiYEffects of water-immersion stress on gastric secretion and mucosal blood flow in ratsGastroenterol19797729830210.1016/0016-5085(79)90281-6Search in Google Scholar
Zhong C, Zhan P, Tian H, Wang P, Lei F. Anti-ulcer activity of the three different extracts of Ferula lehmannii Boiss leaf in rats. Pak J Pharm Sci. 2019 Nov;32(6):2625-32.ZhongCZhanPTianHWangPLeiFAnti-ulcer activity of the three different extracts of Ferula lehmannii Boiss leaf in ratsPak J Pharm Sci2019Nov326262532Search in Google Scholar
Adzu B, Balogun SO, Pavam E. Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms. J Ethnopharmacol. 2015;22:152-5.AdzuBBalogunSOPavamEEvaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei HarmsJ Ethnopharmacol201522152510.1016/j.jep.2015.09.02726408044Search in Google Scholar
Wang FY, Liu JM, Luo HH. Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice. World J Gastroenterol. 2015;8:340-51.WangFYLiuJMLuoHHPotential protective effects of Clostridium butyricum on experimental gastric ulcers in miceWorld J Gastroenterol2015834051Search in Google Scholar
Batista LM, de Almeida AB, Lima GR. Gastroprotective effects (in rodents) of a flavonoid rich fraction obtained from Syngonanthus macrolepsis. J Pharm Pharmacol. 2014;66:445-52.BatistaLMde AlmeidaABLimaGRGastroprotective effects (in rodents) of a flavonoid rich fraction obtained from Syngonanthus macrolepsisJ Pharm Pharmacol2014664455210.1111/jphp.12175Search in Google Scholar
Balogun SO, Damazo AS, de Oliveira Martins DT. Helicteres sacarolha A. gastroprotective and possible mechanism of actions in experimental animals. J Ethnopharmacol. 2015;26:176-84.BalogunSODamazoASde Oliveira MartinsDTHelicteres sacarolha A. gastroprotective and possible mechanism of actions in experimental animalsJ Ethnopharmacol2015261768410.1016/j.jep.2015.03.021Search in Google Scholar
Park CH, Son HU, Son M, Lee SH. Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration. Exp Ther Med. 2011;2:843-8.ParkCHSonHUSonMLeeSHProtective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulcerationExp Ther Med20112843810.3892/etm.2011.314Search in Google Scholar
Takahashi T, Suzuki G, Nibuya M. Therapeutic effect of paroxetine on stress-induced gastric lesions in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2012;36:39-43.TakahashiTSuzukiGNibuyaMTherapeutic effect of paroxetine on stress-induced gastric lesions in miceProg Neuropsychopharmacol Biol Psychiatry201236394310.1016/j.pnpbp.2011.08.017Search in Google Scholar
Zhao J, Harada N, Sobue K. Insulin-like growth factor-I reduces stress-induced gastric mucosal injury by inhibiting neutrophil activation in mice. Growth Horm IGF Res. 2009;19:136-45.ZhaoJHaradaNSobueKInsulin-like growth factor-I reduces stress-induced gastric mucosal injury by inhibiting neutrophil activation in miceGrowth Horm IGF Res2009191364510.1016/j.ghir.2008.08.003Search in Google Scholar
Shah PJ, Gandhi MS, Shah MB. Study of Mimusops elengi bark in experimental gastric ulcers. J Ethnopharmacol. 2003;89:305-11.ShahPJGandhiMSShahMBStudy of Mimusops elengi bark in experimental gastric ulcersJ Ethnopharmacol2003893051110.1016/j.jep.2003.09.003Search in Google Scholar
Yesilada E, Gürbüz Í, Toker G. Anti-ulcerogenicactivityandisol ationofthe activeprinciplesfrom Sambucus ebulus L. leaves. J Ethnopharmacol. 2014;153:478–83.YesiladaEGürbüzÍTokerGAnti-ulcerogenicactivityandisol ationofthe activeprinciplesfrom Sambucus ebulus Lleaves. J Ethnopharmacol20141534788310.1016/j.jep.2014.03.004Search in Google Scholar
Arun LB, Arunachalam AM, Arunachalam KD, Annamalai SK, Kumar KA. In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of gymnemic acid isolated from Gymnema sylvestre R Br. BMC Complement Altern Med. 2014;22:14-70.ArunLBArunachalamAMArunachalamKDAnnamalaiSKKumarKAIn vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of gymnemic acid isolated from Gymnema sylvestre R BrBMC Complement Altern Med201422147010.1186/1472-6882-14-70Search in Google Scholar
Al-Said MS, Ageel AM, Parmar NS, Tariq M. Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity. J Ethnopharmacol. 1986;15:2718.Al-SaidMSAgeelAMParmarNSTariqMEvaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activityJ Ethnopharmacol198615271810.1016/0378-8741(86)90165-0Search in Google Scholar
Katsanou E.S, Kyriakopoulou K, Emmanouil C, Fokialakis N, Skaltsounis A.L, Machera K. Modulation of CYP1A1 and CYP1A2 Hepatic Enzymes after Oral Administration of Chios Mastic Gum to Male Wistar Rats. PLOS One. 2014;9:e 100190.KatsanouE.SKyriakopoulouKEmmanouilCFokialakisNSkaltsounisA.LMacheraKModulation of CYP1A1 and CYP1A2 Hepatic Enzymes after Oral Administration of Chios Mastic Gum to Male Wistar RatsPLOS One20149e 10019010.1371/journal.pone.0100190406501324950217Search in Google Scholar
Amang PA, Tan PV, Patamaken SA, Mefe MN. Cytoprotective and antioxidant effects of the methanol extract of Eremomastax speciosa in rats. Afr J Tradit Complement Altern Med. 2013;11:165-71.AmangPATanPVPatamakenSAMefeMNCytoprotective and antioxidant effects of the methanol extract of Eremomastax speciosa in ratsAfr J Tradit Complement Altern Med2013111657110.4314/ajtcam.v11i1.26Search in Google Scholar
Chul-Hong P, Hyung-U S, Minsik S. Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration. Exper Ther Med. 2011;2: 843-8.Chul-HongPHyung-USMinsikSProtective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulcerationExper Ther Med20112843810.3892/etm.2011.314Search in Google Scholar
Takagi, K, Susumu O. A simple method for producing stress ulcers in the rat. Jpn J Pharmacol. 1968;18:9–18.TakagiKSusumuOA simple method for producing stress ulcers in the ratJpn J Pharmacol19681891810.1254/jjp.18.9Search in Google Scholar
Guo S, Gao X, Cao JM et al. Gastric mucosal damage in water immersion stress: Mechanism and prevention with GHRP-6. World J Gastroenterol. 2012;18:3145–55.GuoSGaoXCaoJMet alGastric mucosal damage in water immersion stress: Mechanism and prevention with GHRP-6World J Gastroenterol20121831455510.3748/wjg.v18.i24.3145Search in Google Scholar
Jia Y.T, Wei W, Ma B, et al. Activation of p38 MAPK by reactive oxygen species is essential in a rat model of stress-induced gastric mucosal injury. J Immunol. 2007;179:7808– 19.JiaY.TWeiWMaBet alActivation of p38 MAPK by reactive oxygen species is essential in a rat model of stress-induced gastric mucosal injuryJ Immunol200717978081910.4049/jimmunol.179.11.7808Search in Google Scholar
Das D, Banerjee RK. Effect of stress on the antioxidant enzymes and gastric ulceration. Mol Cell Biochem. 1993;125:115-25.DasDBanerjeeRKEffect of stress on the antioxidant enzymes and gastric ulcerationMol Cell Biochem19931251152510.1007/BF00936440Search in Google Scholar
Ye B, Zhou PY, Jia M. Absence of NF-κB subunit p50 ameliorates cold immobilisation stress-induced gastric ulcers. Biochem Biophys Res Commun. 2013;10:547-51.YeBZhouPYJiaMAbsence of NF-κB subunit p50 ameliorates cold immobilisation stress-induced gastric ulcersBiochem Biophys Res Commun2013105475110.1016/j.bbrc.2013.03.112Search in Google Scholar
Yoshikawa T, Naito Y, Kishi A, et al. Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut. 1993;34:732-7.YoshikawaTNaitoYKishiAet alRole of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in ratsGut199334732710.1136/gut.34.6.732Search in Google Scholar
Van Hecke T, Basso V, De Smet S. Lipid and Protein Oxidation during in Vitro Gastrointestinal Digestion of Pork under Helicobacter pylori Gastritis Conditions.J Agric Food Chem. 2018;66:13000-10.VanHecke TBassoVDe SmetSLipid and Protein Oxidation during in Vitro Gastrointestinal Digestion of Pork under Helicobacter pylori Gastritis ConditionsJ Agric Food Chem201866130001010.1021/acs.jafc.8b04335Search in Google Scholar
Bhattacharjee M, Bhattacharjee S, Gupta A, Banerjee RK. Critical role of an endogenous gastric peroxidase in controlling oxidative damage in H. pylori-mediated and nonmediated gastric ulcer. Free Radic Biol Med. 2002;32:731-43.BhattacharjeeMBhattacharjeeSGuptaABanerjeeRKCritical role of an endogenous gastric peroxidase in controlling oxidative damage in H. pylori-mediated and nonmediated gastric ulcerFree Radic Biol Med2002327314310.1016/S0891-5849(02)00757-8Search in Google Scholar
Bandyopadhyay D, Biswas K, Bhattacharyya M, Reiter RJ, Banerjee RK. Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatonin. Curr Mol Med. 2001;1:501-13.BandyopadhyayDBiswasKBhattacharyyaMReiterRJBanerjeeRKGastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatoninCurr Mol Med200115011310.2174/156652401336348311899094Search in Google Scholar
Andreadou I, Mitakou S, Paraschos S, Efentakis P, Magiatis P, Kaklamanis L, Halabalaki M, Skaltsounis L, Iliodromitis EK.Pistacia lentiscus L. reduces the infarct size in normal fed anesthetized rabbits and possess antiatheromatic and hypolipidemic activity in cholesterol fed rabbits. Phytomedicine. 2016, 15;23:1220-6AndreadouIMitakouSParaschosSEfentakisPMagiatisPKaklamanisLHalabalakiMSkaltsounisLIliodromitisEKPistacia lentiscus L. reduces the infarct size in normal fed anesthetized rabbits and possess antiatheromatic and hypolipidemic activity in cholesterol fed rabbitsPhytomedicine201615231220610.1016/j.phymed.2016.06.00227316396Search in Google Scholar
Kaliora AC, Kountouri AM: Chemopreventive activity of Mediterranean medicinal plants. In: Cancer Prevention—From Mechanisms to Translational Benefits (Georgakilas A, ed.). InTech, Rijeka, Croatia, 2012, pp. 261–84.KalioraACKountouriAMChemopreventive activity of Mediterranean medicinal plantsInCancer Prevention—From Mechanisms to Translational Benefits (Georgakilas A, ed.)InTech, Rijeka, Croatia2012pp2618410.5772/32142Search in Google Scholar
Papalois A, Gioxari A, Kaliora AC. Chios mastic fractions in experimental colitis: implication of the nuclear factor κB pathway in cultured HT29 cells. J Med Food. 2012;15:974-83PapaloisAGioxariAKalioraACChios mastic fractions in experimental colitis: implication of the nuclear factor κB pathway in cultured HT29 cellsJ Med Food2012159748310.1089/jmf.2012.001822891614Search in Google Scholar
Triantafyllou A, Bikineyeva A, Dikalova A et al. Anti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress. Nutrition J. 2011; 10:64-73.TriantafyllouABikineyevaADikalovaAet alAnti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stressNutrition J201110647310.1186/1475-2891-10-64312799821645369Search in Google Scholar
Bebb JR, Bailey-Flitte N, Ala’Aldeen D, Atherton JC. Mastic gum has no effect on Helicobacter pylori load in vivo. J Antimicrob Chemother. 2003;52:522-3.BebbJRBailey-FlitteNAla’AldeenDAthertonJCMastic gum has no effect on Helicobacter pylori load in vivoJ Antimicrob Chemother200352522310.1093/jac/dkg36612888582Search in Google Scholar
Loughlin M.F, Ala’Aldeen DA, Jenks PJ. Monotherapy with mastic does not eradicate H. pylori infection from mice. J Antimicrob Chemother. 2003;51:367-71.LoughlinM.FAla’AldeenDAJenksPJMonotherapy with mastic does not eradicate H. pylori infection from miceJ Antimicrob Chemother2003513677110.1093/jac/dkg05712562704Search in Google Scholar
Bavishi C, Dupont HL. Systematic review: the use of proton pump inhibitors and increased susceptibility to enteric infection. Alim Pharmacol Ther. 2011 Dec;34(11–12):1269–81.BavishiCDupontHLSystematic review: the use of proton pump inhibitors and increased susceptibility to enteric infectionAlim Pharmacol Ther2011Dec3411–1212698110.1111/j.1365-2036.2011.04874.x21999643Search in Google Scholar
Shirasaka, Y; Sager, J. E.; Lutz, J. D.; Davis, C; Isoherranen, N. Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions”. Drug Metab. Dispos. 2013;41 (7): 1414–24.ShirasakaYSager JE.Lutz JD.DavisCIsoherranenNInhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions”Drug Metab. Dispos201341714142410.1124/dmd.113.051722368481923620487Search in Google Scholar
Shimozawa N, Okajima K, Harada N. Contribution of sensory neurons to sex difference in the development of stress- induced gastric mucosal injury in mice. Gastroenterology. 2006;131:1826-34.ShimozawaNOkajimaKHaradaNContribution of sensory neurons to sex difference in the development of stress- induced gastric mucosal injury in miceGastroenterology200613118263410.1053/j.gastro.2006.09.00517087955Search in Google Scholar
Kakagia DD, Tsaroucha A, Lambropoulou MA. Bowel of Flowers. Int J Surg Pathol. 2018:1066896918776800. doi: 10.1177/1066896918776800.KakagiaDDTsarouchaALambropoulouMABowel of FlowersInt J Surg Pathol20181066896918776800. doi10.1177/106689691877680029785868Open DOISearch in Google Scholar
Biswas K, Bandyopadhyay U, Chattopadhyay I, et al. A novel antioxidant and antiapoptotic role of Omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem. 2003;278:10993-11001.BiswasKBandyopadhyayUChattopadhyayIet alA novel antioxidant and antiapoptotic role of Omeprazole to block gastric ulcer through scavenging of hydroxyl radicalJ Biol Chem2003278109931100110.1074/jbc.M21032820012529378Search in Google Scholar
Georgiadis I, Karatzas T, Korou LM et al. Beneficial health effects of Chios Gum Mastic and peroxisome proliferator-activated receptors: indications of common mechanisms. J Med Food. 2015;18:1-10.GeorgiadisIKaratzasTKorouLMet alBeneficial health effects of Chios Gum Mastic and peroxisome proliferator-activated receptors: indications of common mechanismsJ Med Food20151811010.1089/jmf.2014.002125133901Search in Google Scholar
Zhou L, Satoh K, Takahashi K, Watanabe S et al. Re-evaluation of anti-inflammatory activity of mastic using activated macrophages. In Vivo. 2009;23:583–90.ZhouLSatohKTakahashiKWatanabeSet alRe-evaluation of anti-inflammatory activity of mastic using activated macrophagesIn Vivo20092358390Search in Google Scholar
