<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_jccm-2020-0001_s_006_w2aab2b8c37b1b7b1aab1c16b1Aa"><h3>Introduction</h3><p>Hypernatremia is a commonly associated electrolyte disturbance in sepsis and septic shock patients in the ICU. The objective of this study was to identify the prognostic value of hypernatremia in sepsis and septic shock</p></sec><sec id="j_jccm-2020-0001_s_007_w2aab2b8c37b1b7b1aab1c16b2Aa"><h3>Material and Methods</h3><p>A prospective study conducted on sepsis and septic shock patients diagnosed prior to admission in the ICU in King Hamad University Hospital, Bahrain from January 1st 2017 to February 28th 2019. Data including age, sex, comorbidities, source of sepsis, sodium levels on days one, three, and seven. Data was correlated with the outcome (survival/death and the length of ICU stay).</p></sec><sec id="j_jccm-2020-0001_s_008_w2aab2b8c37b1b7b1aab1c16b3Aa"><h3>Results</h3><p>Patients included were 168, 110 survived, and 58 died. Hypernatraemia at day seven was associated with significantly higher mortality (P= 0.03). Hypernatraemia at Day1was associated with a significantly prolonged stay in the ICU (p= 0.039).Multivariate analysis to identify the independent predictors of mortality revealed that immunosuppression and hypernatraemia at Day7 proved to be independent predictors of mortality (P= 0.026 and 0.039 respectively).</p></sec><sec id="j_jccm-2020-0001_s_009_w2aab2b8c37b1b7b1aab1c16b4Aa"><h3>Conclusion</h3><p>Hypernatremia can be an independent predictor of poor outcome in septic and septic shock patients in the ICU.</p></sec></abstract>

IntroductionHypernatremia is a commonly associated electrolyte disturbance in sepsis and septic shock patients in the ICU. The objective of this study was to identify the prognostic value of hypernatremia in sepsis and septic shockMaterial and MethodsA prospective study conducted on sepsis and septic shock patients diagnosed prior to admission in the ICU in King Hamad University Hospital, Bahrain from January 1st 2017 to February 28th 2019. Data including age, sex, comorbidities, source of sepsis, sodium levels on days one, three, and seven. Data was correlated with the outcome (survival/death and the length of ICU stay).ResultsPatients included were 168, 110 survived, and 58 died. Hypernatraemia at day seven was associated with significantly higher mortality (P= 0.03). Hypernatraemia at Day1was associated with a significantly prolonged stay in the ICU (p= 0.039).Multivariate analysis to identify the independent predictors of mortality revealed that immunosuppression and hypernatraemia at Day7 proved to be independent predictors of mortality (P= 0.026 and 0.039 respectively).ConclusionHypernatremia can be an independent predictor of poor outcome in septic and septic shock patients in the ICU.

Prevalence and Prognostic Impact of Hypernatremia in Sepsis and Septic Shock Patients in The Intensive Care Unit: A Single Centre Experience

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

IntroductionHypernatremia is a commonly associated electrolyte disturbance in sepsis and septic shock patients in the ICU. The objective of this study was to...

Prevalence and Prognostic Impact of Hypernatremia in Sepsis and Septic Shock Patients in The Intensive Care Unit: A Single Centre Experience

Article Category: Research Article

Published Online: Jan 31, 2020

Page range: 52 - 58

Received: Oct 19, 2019

Accepted: Jan 12, 2020

DOI: https://doi.org/10.2478/jccm-2020-0001

Keywords
sepsis, hypernatremia, biomarkers

© 2020 Mohamed Shirazy, Islam Omar, Duaa Abduljabbar, Kamel Bousselmi, Maryam Alkhaja, Anis Chaari, Vipin Kauts, Karim Hakim, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Prevalence and Prognostic Impact of Hypernatremia in Sepsis and Septic Shock Patients in The Intensive Care Unit: A Single Centre Experience

Article Category: Research Article

Published Online: Jan 31, 2020

Page range: 52 - 58

Received: Oct 19, 2019

Accepted: Jan 12, 2020

DOI: https://doi.org/10.2478/jccm-2020-0001

Keywordssepsis, hypernatremia, biomarkers

© 2020 Mohamed Shirazy, Islam Omar, Duaa Abduljabbar, Kamel Bousselmi, Maryam Alkhaja, Anis Chaari, Vipin Kauts, Karim Hakim, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
sepsis, hypernatremia, biomarkers