<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The case is reported of a 39-year-old severely obese woman who developed acute metabolic disorders after the administration of a short course of intravenous amiodarone. The main biological features were hypertriglyceridemia, hypoglycaemia, hyperlactatemia and hyperammonemia; all were reversible after amiodarone discontinuation. There was an associated rise in liver enzymes. However, the influence of co-factors on these metabolic disorders, such as acquired carnitine deficiency, severe obesity, a long-term course of pancreatitis, and abdominal infections, could not be excluded.</p></abstract>

The case is reported of a 39-year-old severely obese woman who developed acute metabolic disorders after the administration of a short course of intravenous amiodarone. The main biological features were hypertriglyceridemia, hypoglycaemia, hyperlactatemia and hyperammonemia; all were reversible after amiodarone discontinuation. There was an associated rise in liver enzymes. However, the influence of co-factors on these metabolic disorders, such as acquired carnitine deficiency, severe obesity, a long-term course of pancreatitis, and abdominal infections, could not be excluded.

Hyperammonemic Encephalopathy and Lipid Dysmetabolism in a Critically Ill Patient after A Short Course of Amiodarone

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The case is reported of a 39-year-old severely obese woman who developed acute metabolic disorders after the administration of a short course of intravenous...

Hyperammonemic Encephalopathy and Lipid Dysmetabolism in a Critically Ill Patient after A Short Course of Amiodarone

Article Category: Case report

Published Online: Nov 27, 2019

Page range: 161 - 165

Received: May 14, 2019

Accepted: Oct 29, 2019

DOI: https://doi.org/10.2478/jccm-2019-0026

Keywords
amiodarone, fatty acids, beta-oxidation, hyperammonemia

© 2019 Maximilien Cappe, Philippe Hantson, Mina Komuta, Marie-Françoise Vincent, Pierre- François Laterre, Ismaïl Ould-Nana, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Hyperammonemic Encephalopathy and Lipid Dysmetabolism in a Critically Ill Patient after A Short Course of Amiodarone

Article Category: Case report

Published Online: Nov 27, 2019

Page range: 161 - 165

Received: May 14, 2019

Accepted: Oct 29, 2019

DOI: https://doi.org/10.2478/jccm-2019-0026

Keywordsamiodarone, fatty acids, beta-oxidation, hyperammonemia

© 2019 Maximilien Cappe, Philippe Hantson, Mina Komuta, Marie-Françoise Vincent, Pierre- François Laterre, Ismaïl Ould-Nana, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
amiodarone, fatty acids, beta-oxidation, hyperammonemia