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Cardiotoxicity in Oncology: Prevention and Management through Cardiovascular Rehabilitation

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Mar 18, 2025

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Talty, A., Morris, R. & Deighan, C. Home-based self-management multimodal cancer interventions & cardiotoxicity: a scoping review. Cardio-Oncology 10, 12 (2024). https://doi.org/10.1186/s40959-024-00204-6 Search in Google Scholar

Caroline Schneider, Annika Dierks, Manuela Rabaglio, et al. Timing of cardio-oncological rehabilitation and cardiorespiratory fitness in patients receiving cardiotoxic chemotherapy: a longitudinal observational study, Swiss Medical Weekly, 154, 6, (3588), (2024). https://doi.org/10.57187/s.3588 Search in Google Scholar

Schneider C, Dierks A, Rabaglio M, Campbell KL, Wilhelm M, Eser P. Timing of cardio-oncological rehabilitation and cardiorespiratory fitness in patients receiving cardiotoxic chemotherapy: a longitudinal observational study. Swiss Med Wkly. 2024 Jun 17;154:3588. doi: 10.57187/s.3588. Search in Google Scholar

Morelli MB, Bongiovanni C, Da Pra S, et al. Cardiotoxicity of Anticancer Drugs: Molecular Mechanisms and Strategies for Cardioprotection. Front Cardiovasc Med. 2022 Apr 15;9:847012. doi: 10.3389/fcvm.2022.847012. Search in Google Scholar

Elad, B.; Habib, M.; Caspi, O. Cardio-Oncology Rehabilitation — Present and Future Perspectives. Life 2022, 12, 1006. https://doi.org/10.3390/life12071006 Search in Google Scholar

Irma Bisceglia, Elio Venturini, Maria Laura Canale, et al. Cardio-oncology rehabilitation: are we ready?, European Heart Journal Supplements, Volume 26, Issue Supplement_2, April 2024, Pages ii252–ii263, https://doi.org/10.1093/eurheartjsupp/suae030 Search in Google Scholar

Meijers WC, de Boer RA. Common risk factors for heart failure and cancer. Cardiovasc Res. 2019 Apr 15;115(5):844-853. doi: 10.1093/cvr/cvz035. Search in Google Scholar

de Boer RA, Meijers WC, van der Meer P, van Veldhuisen DJ. Cancer and heart disease: associations and relations. Eur J Heart Fail. 2019 Dec;21(12):1515-1525. doi: 10.1002/ejhf.1539. Search in Google Scholar

Bertero E, Canepa M, Maack C, Ameri P. Linking Heart Failure to Cancer: Background Evidence and Research Perspectives. Circulation. 2018 Aug 14;138(7):735-742. doi: 10.1161/CIRCULATIONAHA.118.033603. Search in Google Scholar

Kerrigan DJ, Reddy M, Walker EM, et al. Cardiac Rehabilitation Improves Fitness in Patients With Subclinical Markers of Cardiotoxicity While Receiving Chemotherapy: A RANDOMIZED CONTROLLED STUDY. J Cardiopulm Rehabil Prev. 2023 Mar 1;43(2):129-134. doi: 10.1097/HCR.0000000000000719. Search in Google Scholar

Li DL, Wang ZV, Ding G, et al. Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification. Circulation. 2016 Apr 26;133(17):1668-87. doi: 10.1161/CIRCULATIONAHA.115.017443. Search in Google Scholar

Fedele C, Riccio G, Malara AE, D’Alessio G, De Lorenzo C. Mechanisms of cardiotoxicity associated with ErbB2 inhibitors. Breast Cancer Res Treat. 2012 Jul;134(2):595-602. doi: 10.1007/s10549-012-2103-8. Search in Google Scholar

Fuller SJ, Sivarajah K, Sugden PH. ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium. J Mol Cell Cardiol. 2008 May;44(5):831-54. doi: 10.1016/j.yjmcc.2008.02.278. Search in Google Scholar

Gronek P, Wielinski D, Cyganski P, et al. A Review of Exercise as Medicine in Cardiovascular Disease: Pathology and Mechanism. Aging Dis. 2020 Mar 9;11(2):327-340. doi: 10.14336/AD.2019.0516. Search in Google Scholar

Powers SK, Deminice R, Ozdemir M, et al. Exercise-induced oxidative stress: Friend or foe? J Sport Health Sci. 2020 Sep;9(5):415-425. doi: 10.1016/j.jshs.2020.04.001. Search in Google Scholar

Hollings M, Gordon N, Redfern J, Thomas L, Singleton A, et al. Characteristics and Outcomes of Cardiac Rehabilitation Patients With and Without Cancer: Insights From Western Sydney. Heart Lung Circ. 2024 May;33(5):730-737. doi: 10.1016/j.hlc.2023.11.017. Search in Google Scholar

Díaz-Balboa E, Peña-Gil C, Rodríguez-Romero B, et al. Exercise-based cardio-oncology rehabilitation for cardiotoxicity prevention during breast cancer chemotherapy: The ONCORE randomized controlled trial. Prog Cardiovasc Dis. 2024 Jul-Aug;85:74-81. doi: 10.1016/j.pcad.2024.02.002. Search in Google Scholar

Amin AM, Khlidj Y, Abuelazm M, et al.The efficacy and safety of exercise regimens to mitigate chemotherapy cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials. Cardio-oncology. 2024 Feb 23;10(1):10. doi: 10.1186/s40959-024-00208-2. Search in Google Scholar

Jones LW, Eves ND, Mackey JR, Peddle CJ, Haykowsky M, Joy AA, et al. Systemic infammation, cardiorespiratory ftness, and quality of life in patients with advanced non-small cell lung cancer. J Thorac Oncol. 2008;3(2):194–5. https://doi.org/10.1097/JTO.0b013e318160f36b. Search in Google Scholar

Kwon I. Protective effects of endurance exercise on skeletal muscle remodeling against doxorubicin-induced myotoxicity in mice. Phys Act Nutr. 2020 Jun 30;24(2):11-21. doi: 10.20463/pan.2020.0010. Search in Google Scholar

Schmielau J, Rick O, Reuss-Borst M, et al. Rehabilitation of Cancer Survivors with Long-Term Toxicities. Oncol Res Treat. 2017;40(12):764-771. doi: 10.1159/000485187. Search in Google Scholar

Gonella F, Massucco P, Perotti S, et. al. Telemedicine prehabilitation as a result of COVID-19: disruptive technological solutions. Br J Surg. 2021 Jun 22;108(6):e215-e216. doi: 10.1093/bjs/znab066. Search in Google Scholar

Ariza-Garcia A, Lozano-Lozano M, Galiano-Castillo N, et al. A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial. J Med Internet Res. 2019 Jul 24;21(7):e14418. doi: 10.2196/14418. Search in Google Scholar

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