Omicron Variant Behavior in a Couple: Vaccinated Versus Non-Vaccinated

Infection with severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) may present as the common cold, or in a series of cases can also result in severe or fatal pneumonia with severe respiratory distress. Since the virus’s first appearance in December 2019, multiple studies have focused on clinical manifestations and biological features of different COVID variants in these five pandemic waves. Also, the variety of symptoms, the severity of the disease and the assessment of risk factors in each individual has continuously evolved among these two years, due to updated data published worldwide. The current paper presents the case of two patients, husband and wife, who develop a similar COVID-19 infection with only mild symptoms, although their disease history and COVID vaccination status is very different. They were among the first confirmed Omicron variant cases by genome sequencing in Romania and their favorable outcome despite the risk factors was encouraging for our every day practice.