1. bookVolume 65 (2021): Issue 4 (December 2021)
Journal Details
First Published
30 Mar 2016
Publication timeframe
4 times per year
Open Access

Genes of Congenital Dermatologic Disorders in Dogs—A Review

Published Online: 30 Dec 2021
Volume & Issue: Volume 65 (2021) - Issue 4 (December 2021)
Page range: 38 - 46
Received: 17 Sep 2021
Accepted: 29 Oct 2021
Journal Details
First Published
30 Mar 2016
Publication timeframe
4 times per year

This article presents an overview of up-to-date identified genes responsible for congenital canine skin diseases of dogs and the characteristics of these diseases. Congenital skin diseases constitute a specific group of dermatologic disorders that plays an important role in breeding of purebred dogs. They include primary seborrhoea, ichthyosis, hereditary nasal parakeratosis, dermatomyositis, colour dilution alopecia, skin mucinosis, dermoid sinus, lethal acrodermatitis, acral mutilation syndrome, keratoconjunctivitis sicca, ichthyosiform dermatosis, bullous epidermolysis, exfoliative dermal lupus erythematosus, congenital footpad hyperkeratosis and sebaceous adenitis. In the majority of cases, their occurrence is linked to particular breeds. In more than half of these diseases a specific defective gene variant responsible for the disease has been identified. Genetic tests for identification of the relevant defective genes serve as an important tool in the diagnostics of diseases in veterinary practice and in breeding of purebred dogs.

Key words

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