1. bookVolume 65 (2021): Issue 4 (December 2021)
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Journal
eISSN
2453-7837
First Published
30 Mar 2016
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4 times per year
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English
access type Open Access

Fascinating Dendritic Cells—Sentinel Cells of the Immune System a Review

Published Online: 30 Dec 2021
Volume & Issue: Volume 65 (2021) - Issue 4 (December 2021)
Page range: 12 - 19
Received: 25 Aug 2021
Accepted: 04 Oct 2021
Journal Details
License
Format
Journal
eISSN
2453-7837
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
Abstract

Dendritic cells (DC) are specialized antigen presenting cells which have the unique ability to activate naive T-lymphocytes. Their role in the immune system is much more sophisticated than it seems, as they do not kill the pathogens directly, but provide a long-lasting antigen specific immune response thanks to that sufficiently bridging the innate and the adaptive immunity. In recent years, there has been a growing interest in studies of their role in immune regulation, autoimmune reactions, as well as in immune responses against pathogens and tumours. Processing and presentation capabilities of a highly specific and unique tumour antigen makes them an interesting tool for stimulating effective anti-tumour immunity. In vitro generations of DC represent a preferred model for more detailed studies of DC biology in other fields. The aim of this review was to discuss the main role of dendritic cells in the body as well as their current use as experimental models for further scientific studies.

Key words

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