Role of alpha and gamma Klotho genes in the development of differentiated thyroid carcinoma on top of goiter
Article Category: Research Article
Published Online: Sep 15, 2023
Page range: 31 - 39
Received: Dec 15, 2022
Accepted: Jul 25, 2023
DOI: https://doi.org/10.2478/fco-2023-0006
Keywords
© 2023 Wesam S. El-Saeed et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Background
Differentiated thyroid carcinoma (DTC) is the most common malignant tumor of the endocrine system. Our study is aimed to investigate the role of the α- and γ-Klotho genes in the development and progression of DTC.
Methods
The expression of the α- and γ-Klotho genes was assessed by quantitative real-time polymerase chain reaction (RT-qPCR) in thyroid tissues of 40 DTC patients and 40 age- and sex-matched subjects diagnosed as goiter and included as a control group. The demographic, laboratory and clinicopathological data of the subjects were reviewed to detect their association with the Klotho genes.
Results
The α-Klotho gene expression was statistically significantly lower in DTC tissues compared to goiter tissues (
Conclusions
Our study showed the role of the α-Klotho gene as a potential novel biomarker for discrimination between DTC and goiter tissues. Low α-Klotho mRNA expression was found to be a significant predictor for the likelihood of DTC on top of goiter, as well as higher stages of this tumor.