Role of alpha and gamma Klotho genes in the development of differentiated thyroid carcinoma on top of goiter
, , , and | Sep 15, 2023
About this article
Article Category: Research Article
Published Online: Sep 15, 2023
Page range: 31 - 39
Received: Dec 15, 2022
Accepted: Jul 25, 2023
DOI: https://doi.org/10.2478/fco-2023-0006
Keywords
© 2023 Wesam S. El-Saeed et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1:
Correlations of the α-Klotho gene expression with γ-Klotho gene expression and with different parameters.
| γ |
−0.065 | 0.565 |
| −0. 233 | ||
| −0.210 | 0.194 | |
| 0.084 | 0.606 | |
| 0.101 | 0.534 | |
| −0.258 | 0.108 | |
| −0.346 | ||
| −0.898 | ||
Association between the demographics and the clinicopathological parameters and the two groups of the α-Klotho gene expression.
| 4 (80%) | 21 (60%) | |||
| ≥ |
1 (20%) | 14 (40%) | ||
| 1 (20%) | 8 (22.9%) | |||
| 4 (80%) | 27 (77.1%) | |||
| 30.3±5.4 | 30.3±6.4 | |||
| 0.94±0.4 | 2.91±0.9 | |||
| 3 (60.0%) | 17 (49.0%) | |||
| 2 (40.0%) | 18 (51.0%) | |||
| 3 (60.0%) | 22 (62.9%) | |||
| 2 (40.0%) | 13 (37.1%) | |||
| 4 (80.0%) | 20 (57.1%) | |||
| 1 (20.0%) | 15 (42.9%) | |||
| 4 (80.0%) | 30 (85.7%) | |||
| 1 (20.0%) | 5 (14.3%) | |||
| 5 (100.0%) | 27 (77.1%) | |||
| 0 (0.0%) | 8 (22.9%) | |||
| 5 (100.0%) | 23 (65.7%) | |||
| 0 (0.0%) | 12 (34.3%) | |||
| 5 (100.0%) | 17 (48.6%) | |||
| 0 (0.0%) | 18 (51.4%) | |||
| 4 (80.0%) | 27 (77.1%) | |||
| 1 (20.0%) | 8 (22.9%) | |||
| 3 (60.0%) | 16 (45.7%) | |||
| 2 (40.0%) | 19 (54.3%) | |||
| 0 (0.0%) | 15 (42.9%) | |||
| 5 (100.0%) | 20 (57.1%) | |||
| 5 (100%) | 27 (77.1%) | |||
| 0 (0%) | 3 (8.6%) | |||
| 0 (0%) | 1 (2.9%) | |||
| 0 (0%) | 4 (11.4%) | |||
Predictors of higher stage of DTC.
| 2.2395(0.747–7.675) | 0.142 | |
| 1.220(0.956–1.56) | 0.110 | |
| 0.812(0.587–1.125) | 0.211 | |
| α |
0.671(0.246–0.835) |
Logistic regression analysis to predict the likelihood of DTC on top of goiter.
| 0.998 | 0.99–1.006 | 0.626 | |
| 1.023 | 0.83–1.26 | 0.831 | |
| 1.004 | 0.97–1.039 | 0.836 | |
| 1.063 | 0.95–1.19 | 0.285 | |
| α |
0.506 | 0.343–0.746 | |
| γ |
1.059 | 0.893–0.1.256 | 0.508 |
Correlations of the γ-Klotho gene expression with different parameters.
| γ |
||
|---|---|---|
| −0.028 | 0.866 | |
| −0.254 | 0.114 | |
| 0.186 | 0.250 | |
| 0.244 | 0.130 | |
| −0.156 | 0.338 | |
| −0.104 | 0.525 | |
| −0.089 | 0.586 | |
Demographic and laboratory parameters of the studied groups.
| 41.08 ± 11.3 | 41.08 ± 11.3 | ||
| |
|||
| |
9 (22.5%) | 9 (22.5%) | |
| |
31 (77.5%) | 31 (77.5%) | |
| 30.30 ± 6.2 | 33.80 ± 5.4 | ||
| 1.27 ± 0.4 | 1.23 ± 0.3 | ||
| 7.24 (6.50–8.25) | 7.85 (6.30–8.85) | ||
| 1.10 (0.66–1.58) | 0.82 (1.03–2.45) | ||